I suppose that it depends on your opinion of the importance of prolonged human presence in space... Namely the Moon. I'm only guessing, but I would venture to guess that there will be permanent bases (maybe military) on the Moon within the next 50 years. Much bio research has been done on the ISS that will support extended stays on the Moon (or in microgravity in general).

Agree! Those costs don't include NASA's incredible infrastructure costs. Orbital and SpaceX have to create and pay for their own infrastructure (launch site and data communications). All they get is some real estate on a launch campus. In general, seems most folks in this thread have never worked on rockets or spacecraft. It really IS rocket science and it really IS hard... and it really IS very expensive. The hardest part about CRS is the business model... matching the loft capabilities of a brand new rocket (Orbital's Taurus-II and SpaceX's Falcon-9) to the unknown mass (weight) of a brand new SET of spacecraft while leaving room for the stuff that you get paid for (the cargo). Keep in mind the design teams have to develop a spacecraft that can accommodate unpressurized and pressurized cargo... with capabilities to accommodate a return vehicle as well. Also, in contrast to comments above, the government is not supplying anything other than specifications for operations near the ISS. Orbital and SpaceX have developed both rocket and spacecraft designs in-house with no help from NASA. I can't speak for SpaceX, but Orbital has some of the best rocket designers in the world. From http://www.orbital.com/SpaceLaunch/: "Combined, our space launch vehicles have launched over 115 satellites into orbit in the last 18 years." This does not include the interceptor or target systems developed by orbital (in-house). Watch out ULA (United Launch Alliance - Lockheed and Boeing's rocket business) there's some new kids on the block ;-)