Elite: Dangerous, with a proper HOTAS setup, is an excellent example of how a flight sim game in VR should work. Because of the nature of the game, they were able to virtually position all the HUD elements quite ideally for VR play. (However, once in a while, you still may need to attempt to touch-type on a keyboard for searching for star systems... Not frequently, though.)
More realistic flight sims are severely harmed by the limited resolution, and lack of comfortable close-focus, because its hard to visually resolve the cockpit controls. But if you don't need to do that, then VR works great.
Seriously, right now about 90% of my Oculus time is spent in Elite, and I really do not want to ever play that game in non-VR again.