Comment The main problem is actually hitting the drone (Score 1) 157
Let's assume that the human pilot can outsmart the drone and achieve a firing position. What weapon could the pilot use to make the kill? Guns won't work, because the drone could out turn the human making the straight-line gun ineffective. Similarly, a missile is at a disadvantage (depending on its range, stealth, and kill-radius characteristics) because its smaller control surfaces generally limit its turning capability compared to the larger fighter.
So hitting the drone isn't that easy ... unless you were using directed-energy weapons or augmented flight controls that let your fighter take over when you blacked out.
As the fight wore on it would inevitably drop to lower altitude as you lose energy. Now you're stuck fighting in essentially 2D rather than 3D space...the human is in real trouble now.