Dragon Warrior, Illusion of Gaia, Terranigma, E.V.O. Search For Eden, Star Ocean, Wonder Project J, and so forth. Enix didn't just stick to your common RPG where you had menus and went around finding enemies to level up, but instead took a more creative approach to change how you played the game. Many of their games were never seen outside of Japan, yet since being fan translated many are considered just as appealing.
Since their merger though I've yet to see anything creative come out of the company. Even before the merger it still felt like Square was trying to milk all they could out of the already perfectly received gameplay and story basis used in the FF series. And then when they were being creative(like with The World Ends With You) it felt like FFVII all over again with different artwork and themes involved.