Ivermectin for COVID-19: real-time meta analysis of 64 studies https://ivmmeta.com/ Meta analysis using the most serious outcome reported shows 68% [52â'78%] and 86% [75â'92%] improvement for early treatment and prophylaxis, with similar results after exclusion based sensitivity analysis and restriction to peer-reviewed studies or Randomized Controlled Trials. âStatistically significant improvements are seen for mortality, ventilation, hospitalization, recovery, cases, and viral clearance. 29 studies show statistically significant improvements in isolation. âResults are very robust â" in worst case exclusion sensitivity analysis 53 of 64 studies must be excluded to avoid finding statistically significant efficacy. Studies Prophylaxis Early treatment Late treatment Patients Authors All studies 64 86% [75â'92%] 68% [52â'78%] 40% [24â'52%] 26,509 641 Peer-reviewed 45 86% [74â'93%] 70% [52â'81%] 43% [21â'59%] 17,316 490 Randomized Controlled Trials 32 84% [25â'96%] 63% [45â'75%] 30% [2â'50%] 6,648 387 Percentage improvement with ivermectin treatment âWhile many treatments have some level of efficacy, they do not replace vaccines and other measures to avoid infection. Only 27% of ivermectin studies show zero events in the treatment arm. âElimination of COVID-19 is a race against viral evolution. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. All practical, effective, and safe means should be used. Those denying the efficacy of treatments share responsibility for the increased risk of COVID-19 becoming endemic; and the increased mortality, morbidity, and collateral damage. âThere is evidence of a negative publication bias, and the probability that an ineffective treatment generated results as positive as the 64 studies is estimated to be 1 in 222 billion. âThe evidence base is much larger and has much lower conflict of interest than typically used to approve drugs. âAll data to reproduce this paper and sources are in the appendix. See [Bryant, Hariyanto, Kory, Lawrie, Nardelli] for other meta analyses with similar results confirming efficacy.

It's not the actual zoned out act of texting that is the disturbance. Aside from people not putting their devices on silent (without Vibrate which is usually not very silent) ...Device screens are VERY bright. And it seems most folks dont have their set to automatically adjust, or they simply can't dim enough not to visually distract other patrons. All those lights popping on throughout a public performance, like a concert or a movie, can be very distracting, especially in a movie a live theater performance, concerts less so, depending on the lighting design of the show.

I do pine for my old Nokia. Battery lasts a week, great reception, clearer calls, AND.. I can successfully manage Call Waiting without dropping the other or both callers every single time (...thanks Droid2, Droid3, Droid4, iPhone5s, iPhone6) And I loved the old call management functions.. used to be I could use codes or menu functions to forward calls when I am unavailable, such as when I am in the mountains and intermittently in coverage. I could forward the calls to the landline in the condo. Now, that functionality does not exist whatsoever in the mobile, at least not on Motorola's version of Android.

You make a fair point. One often overlooked issue with earnings and cost of living is what we actually take home. A few years back, I was enlightened on this topic after reading a Forbes article that questioned the common rubric used to estimate which cities are more expensive to live in than others. Most of those calculations focus on the cost of living without taking into account the ability to earn in that market. For example, I live in Atlanta. We have relatively low average household income, the lowest of the 15 peer MSA's. (Metropolitan Statistical Areas). Otherwise uninformed hires will take a job here since they view our cost of living as being a lot lower than many of the peer MSA's. I see lots of people who relocated here from some part or another of Michigan, stuck in a retail job, and worried about their prospects since it costs more to live here than where they came from. So, the actual measure I like to use is the amount of money we get to keep and use after we earn our money from employment/business activities, and then pay off the costs of living. Atlanta ended up being one of the most expensive cities when this rubric was applied. Bay Area was actually one of the more attractive cities. So, I can see where earning a US$25k/yr in a city in Mexico could really be quite comfortable. Thailand would be similar, for example. Healthcare is a lot less expensive in both countries, food is less expensive, housing, etc. The typical items are less expensive in the US are technology gadgets and automobiles/fuel. This rubric does have a big GOTCHA. If you live in an area like the Bay Area/SF which has a very high cost of living, and you fail to stay in the viable bubble of earnings that make it livable, you have a huge gap to fall into. This is especially true in markets like Atlanta that have relatively few, if any, meaningful social services other than for the very least wealthy among us. If you are lower middle or below class in Atlanta, you live on a treadmill, have to suck up whatever your boss throws your way, and are a paycheck or two away from joining the tent campers under the I20 I75/85 overpass, just two blocks from our State Capitol complex, Atlanta City Hall, and Fulton County's Courthouse.

These "Officials" that write these laws dont know what they are talking about. You can NOT print a lower or upper receiver, the barrel, or the trigger mechanisms for 3d printed guns. You can only print a few things successfully, like the rails, the grip/stock, maybe a magazine (without any of the springs which it needs to operate). So.. why bother making the law? Just to make everyone that much more Skeered.

Agreed. Without the ability to make a choice, then a monopoly will exist. "Voting" by exercising an economic choice with a market incentivizes the competing schools available within the market to deliver better quality of service and to do so more efficiently. Here is how it plays out in Atlanta GA. Full disclosure, I have no children, I went to an Atlanta Public School in the 80's, and I am actively involved in local politics in various forums (not online forums) of activity. 4/7 of my property taxes go towards the local public schools, specifically, Atlanta Public Schools. We spend the most in Georgia per student, and have the lowest scores and lowest succesa rate in terms of generating viable income earning economically, self-sustaining adults without need for government social welfare assistance. In my zipcode, 30318, the largest zip in Atlanta, 1 out of 10 men has been, or is currently, in jail. I would propose a better solution. Allow MORE people to afford Private School Tuition or alternative education such as Home Schooling by allowing them to credit the tuitions paid to accredited programs or schools from their property taxes. The current system essentially guarantees only those high levels of disposable income will be able to afford the School Taxes and the Private School Tuitions. Allowing citizens to take a credit off their Property Taxes for tuition paid to an Accredited program increase access to Private Schools and provide more competition in the market which will lead to enhanced service delivery by the public schools. It would also lead to more diveristy in the formats of the Private Schools, further promoting freedoms of choice in the market. This may even reduce overcrowding in Public School classrooms. As for the status quo, I live in the United States, which ranks a shameful 17th in the world for pre-University education. I live in Georgia, a state which usually ranks between 46th and 49th in the United States. In live Atlanta (ITP/urban/downtown/center), where our three main school districts, Dekalb, Clayton, and Atlanta City have longstanding, ongoing, chronic, severe, and systemic problems. APS, Atlanta Public Schools has 35 teachers and administrators under felony indictment for criminal conspiracy and fraud. There was a test score cheating racket busted where over 200 Atlanta Public Schools employees were involved in literally helping students fill in the bubbles correctly on the tests. If a student had a Learning Disability and then tested well with the teacher's help, then that student would not be able to access the LD services they would otherwise need. Dekalb pays their School Board Commissioners $250,000/year in salary. Two of them were asked to resign under suspicion of taking kick backs from ongoing school renovations underway between 2005 and 2009. One administrator took a $1.25 million golden parachute of 5 years pays to resign. Another took a severance payment of four month's pay, $83,000. Teachers in DeKalb County consider themselves lucky if they earn more than $40,000/year in Salary. Recently, two more School Board Commissions were fired for the exact same reasons, taking kickbacks from the renovations that are now in their 7th year of the project, with no end in sight. Clayton County lost their accreditations a few years back. They were only reinstated a couple of years later. All of those students graduating during that time frame may or may not hold valid diplomas. I am not 100% sure, but I seem to recall those students having to take a GED to gain a qualified diploma. Here in Atlanta, we do take action politically simply because we are already paying for these schools out of our taxes, regardless of whether or not we are using the system. If you have no children, you are subsidizing these under-performing and corrupt school systems so families who can't afford private schools can get a free education at a substandard institution. This undermines the economic viablity of our region by producing lower quality employees for the job market. And large companies do dashboard this factor when selecting their new operating facilities, expanding these, or relocating them out of the market and shutting them down. Case in point is Goodyear Wingfoot relocated a Commercial Tire Plant from the center of town to Bremen GA about 90 miles to the West. The primary reason was the lack of trainable workers. Enough said. Oh, and I should add, I taught as a professor at Georgia Perimeter College at the Clarkston Campus. We have a large number of students in remedial education programs, including remedial reading. I had students who did not know how to name a file in their computer, then intentionally save it to a jump drive on a school workstation. They did not know how to type. They could barely use email. They could barely draft a document in Word or similar applications. They could not find the file again if they saved it to the workstation since the workstations automatically wipe the hard drives every night at Midnight. They thought they had saved it to a jump drive, but failed to do so, and then end up losing all their work, and receive a failing grade on an assignment since the work is missing when they arrive in class with the jump drive. The online education system, Blackboard, was installed in 2000 or 2001. The company was bought out by another vendor about 8 years ago. The new company has not upgraded the online portal system since that time. The system often crashes during a timed drill, exercise or test. As a professor, I have no way of verifying a student's workstation crashed, so I have to assign them a failing grade. I did try to put into the syllabus a way for them to take a screenshot and send it to me, but 9 out of 10 could not manage it, even with step by step How To instructions, given their low level of computer and reading literacy. The best part is a portion of this online course included teaching them how to use a computer, creating a "Chicken and Egg" logic conundrum. When I raised this obvious issue to the administrator over the course, they simply said I should create training videos. Ok, but in the same breath they do not let me alter the course from the template they produced. A template that contains artifacts in the tests dating back to versions of Microsoft Office in 1996 - 1998. All the while, the paycheck is $700 per credit hour. That works out to less than $10 and hour, and with NO benefits, when you consider that these are asynchronous courses with NO meeting time. Since they signed up for async courses, I was not able to schedule a class meeting for class discussions. This leads to most of the interactions being one off interactions between the professor and student, completely removing the learning possibilities implied by a Socratic discussion forum. There was a forum component, but students rarely read the other posts, and I do not blame them given the poor UI design of the Forum Components.