Have a look at bup (https://github.com/apenwarr/bup). Though still very new and missing some features, it's pretty stable, fast (at deduplication, restore is another story) and very effective. Better ratio than lessfs, sdfs and zfs. I'm rather impressed how it sucks in full partition images, several hundred gigabytes, each day at my place. It's meant for virtual machine images. File based backup is also included, but still missing meta data AFAIK.

Also, have a look at Btrfs. Btrfs does not include deduplication per se yet, but you can use volume snapshots and rsync --inplace so it only does block level changes within updated files, if filenames don't change (watch /var/log).

Wow this was disappointing. I was hoping for an actual hardware cache that can be put between HDD and mobo, with an integrated SATA host. This is a software only solution which can be applied to any SSD.