As a native to the Pacific Northwest, this is something you are constantly aware of. Every time there is a major earthquake or tsunami, the local news posts stories about how the "Big one" is due to hit in the next 50 years. Every time a volcanic eruption becomes major news, we get reports about how Mount Rainer is going to erupt and bury my hometown. I was born a year after our last major volcanic eruption, so you could say that this has been something I have been aware of my entire life.
More interesting than when the big one is going to hit is how well we are setup to handle it when it does. I was in a building rated only for a 7.0 Ricter magnitude quake during our last major quake (which measured 6.8), and there were major fears that the building was going to collapse either during or just after the quake. Luckily for me, it weathered the quake with only minor damage.
However, after the Chile quake last year, I heard a report from our local NPR affiliate comparing the infrastructure of the NW with the infrastructure of Chile (our buildings are built to roughly the same standards, and are around the same age), and mentioning that the state governments up here were taking interest in learning from the lessons of that quake to prepare better for our next big quake.