A long time ago, I used gmail. GMail had a wonderful little bar: combination of RSS reader (80% of the time) and text one-line ad (20% of the time). That got my eyeball, because the 80% useful rate (this was back when I could use a customized RSS feed/selection).
Later, it dropped to 20%; then it went to non-customizable, one size fits all. Then 0% news, all ads.
Around that time, I installed a webmail blocker.
Well, it happened -- system reinstall, webmail blocker didn't work, wasn't available for download. But there was a way at the time to tell Google that I didn't want to see a given ad.
Now, I won't say it was easy to do. But it was doable.
After something like 150 blocked ads, guess what happened? I saw stuff I actually wanted to see.
Yea, how about that? Some targeted combinations of keywords and what I was reading actually matched my interests. But they were way, way down on the list of how much they were willing to pay google, so they were not shown until I blocked all of the big money spenders.
Sadly, Google has made it really hard again to block ads, or at least they did the last time I used Gmail. Now, gmail is nothing more than another imap source for me.
** Make it easy for people to say "I don't want to see an ad for ". Make it easy for people to see what other stuff is being pushed by the cheaper people.
Chances are, it's more likely to be of interest.
It might be much more personal / close to home.
In general, the smaller the target audience, the more likely it is to be what you want, and the more likely to be cheap. But it will be a clicked cheap link.