I'm always surprised when people write off the DS as being unfriendly to "Serious" Gamers. Seeing how many people, and how diverse a crowd use the DS in Japan, I'll argue that these users are much more serious gamers than half of those that would label themselves that here in the states. The simple reason is downtime while in transit which the Tokyoites and the majority of the country have and the vast majority of people in the states don't. There is something that makes you smile about sitting on the Chuo Rapid line and seeing 3 or 4 Salarymen playing on their respective DSs (and PSPs).
That aside, GTA CTW is one of the most enjoyable games I've played for the DS in a long time. I've been playing JP games for quite some time to get a decent game on, and I salute Rockstar for their efforts in the US with this one. If you haven't tried it out, give it a go. If you are the type that enjoys a GTA game, I can virtually assure you that you'll enjoy this one.
Though because of the perspective, I was really waiting for someone to say "No Donation, No salvation"