We've found in our managed environment that when our WSUS server starts pushing out Windows Updates, it can sometimes drop people to a crawl as well.
Sometimes everyone, sometimes just a few.
Not as big of an issue on a private connection, but can lag out your interwebz a bit.
Run "net stop BITS" in a command prompt, and if it suddenly flies again, something is using the Background (Un)intelligent Transfer service and murdering the PC. (which is usually Windows Updates or occasionally MSN Explorer. (does anyone actually use that still?)