Comment Try out MogileFS (Score 3, Informative) 46
We've been using MogileFS on commodity Linux servers for a few months now and it's been working great. The MogileFS community/mailing list is very active, so it's actually been fun to implement.
Right now we have 22.8 TB spread across six 2U servers using a mix of 400 and 500 GB SATA drives. The great thing is that we can lose an entire file server (or two) with no downtime or loss of data.
Another reason to like MogileFS is that it removes the need to maintain RAID arrays. A RAID-5 array made of 750 GB disks is very risky. A high-end controller will still take many hours to rebuild a degraded array, during which time you could lose another disk and be largely screwed. (This actually happened to us very early on and we lost 0.02% of our data after restoring from backup, which still hurt.)