I tried two monitors, but I hated when stuff centered itself in the 'middle' of the screen, so I went with three and could never go back. I actually had 3 17" CRTs for a while, but now I use 3 standard 19" LCDs at 1280x1024. On my older system I had a dual-head AGP card and a PCI VGA card. My current system is a Dell Precision T3400 with dual video cards, each card is capable of driving 2 DVI monitors, although I have no intention of having a forth. I do most of my work on the center screen, the left hand screen usually has my email client, web based documentation, pdfs, etc. and the right screen is where I have RDP connections to servers I'm working with. Of course now that I have everything as I like, macular degeneration is threatinging to screw it all up for me...