Yeah, sounds like they really need a video wall controller instead of each monitor being independently driven. With a video wall controller you can drive all the monitors from a single controller and then resize 'windows (or inputs)' across the hole thing, in a corner, etc. Each input becomes a window. You can also save layouts/change them according to shift/etc.
With a video wall controller you specify the number of inputs/outputs you need. Many also allow for IP based sources (cameras, remote screens via IP, etc).