See here for an explanation: https://security.googleblog.co...

TL;DR is the entire TLD is on the HSTS preload list.

The problem with the monorail is that it was designed as spectacle, not as transit, yet even as spectacle it fails because it's so out of the way that most people never even stumble across it, and if you do take it, all you see are the backs of hotels. It's even priced as spectacle. $2.75 gets you anywhere in New York City via the subway and bus, but it costs $5 to take the monorail just to go 4 miles along the backs of casinos in Las Vegas.

The monorail should have been built in the middle of the Strip. The Strip is a dystopian nightmare highway bifurcating one of the most walked streets in the United States. It's so dangerous that in many places there aren't even any at-grade pedestrian crossings; you have to go up stairs/escalators set back from the strip, go across a bridge, and then back down, often being forced to detour through one or two casinos in the process. It's the ultimate triumph of automobiles over people for no goddamn reason at all.

The mass transit should have been run right down the middle of the Strip. Instead it was forced to the margins where it remains unused, when it was really the car traffic that should have been forced to the margins. Las Vegas should do a NYC-style "Summer Streets" a few times per year and entirely close down the Strip to car traffic for half a day and let pedestrians use it as they'd like, like Mardi Gras. Then people would realize what they've been missing.

FYI, the HSTS preload list is used by all major browsers (Chrome, Firefox, IE, Edge, Safari, Opera, etc.). This is a good thing, of course; online security shouldn't be enforced conditionally depending on which browser you're using.

The linked article got it wrong. This isn't about Chrome adding TLDs to the HSTS list, it's about the TLDs' owner (which also happens to be Google) adding them to the global HSTS list.

That is the biggest reason I like Google Home. Standing in the kitchen "Hey google, add milk to the shopping list", don't even have to pick up a pen. Super convenient and easy. This is the reason I've never before used an app for a grocery list.

ABS filament for the FDM (melting plastic machine), methacrylates (and photoinitiator compounds, etc) for the stereolithography machine. The original paper in Enviromental Science & Technology Letters is available (with ACS paywall) here.

E47-inducible cell lines were generated by infection with
a retroviral vector expressing E47 fused to a tamoxifen-inducible
modified estrogen receptor (MER).

The way this was done was really clever: it uses a virus that causes cancer to treat cancer. Specifically, the retroviral vector is an engineered strain of Moloney Murine Leukemia Virus (MoMuLV), which can cause leukemia in mice (it is not known to cause disease in humans, though retroviral infection does carry at least a small risk of mutagenesis). The viral vector inserts a gene that expresses the protein E47, which acts in a variety of ways to make cancer cells revert to acting like healthy cells.

This is an exciting idea, though as the press release notes, "we are screening for molecules—potential drugs—that can induce overexpression of E47." That's a way of noting that retroviral vector gene therapy is in its infancy, and that it would be much better if we could find a small molecule instead.

These findings prompted us to ask whether
the growth arrest and acinar gene expression induced in vitro
might be sufficient to diminish the tumor-forming potential of
these aggressively growing cells. Indeed, temporary induction of
E47 for 2 to 8 days in vitro produced stable cell cycle arrest and
trypsinogen expression in transplanted human PDA cells. It will
now be of interest to investigate the effects of E47 on the growth
dynamics of established tumors.

And also the above- established tumors notoriously mutate and become genetically heterogeneous over time, greatly increasing the chances that at least some of the cancer cells are resistant to whatever line of attack you throw at them. Cancer cells that have mutant forms of E47's targets wouldn't be reprogrammed. Still, any advance against pancreatic cancer is highly welcome.

If you do an image search, nearly half of the artist renderings still depict Pluto as blue-grey in color. I think the reasoning was that the planet was thought to be largely covered in methane ice, which has that color. And they were right about the ice, but UV radiation can initiate reactions in methane and diatomic nitrogen to produce a mix of simple hydrocarbons and nitriles, similar to the orange-brown haze that shrouds Titan, just on a much less dramatic scale.

Yes, it's a lot like existing solid-state nucleic acid or peptide synthesis setups, but with the major advantage of forming carbon-carbon bonds instead of phosphodiester or amide linkages, making the technique a lot more general. The setup involves a useful reaction called Suzuki coupling. In Suzuki coupling, a metal (usually palladium) catalyzes a reaction between a halide (that is to say, chlorine, bromine, etc.) and an organoboron compound. The mechanism is complex, but the result is a carbon-carbon single bond. This reaction and similar ones are already widely used in the pharmaceutical industry since they can reliably glue together smaller structures together to make a larger molecule. The smaller structures are not individual atoms, though- they tend to have maybe 10-20 atoms or so. Drugs with biaryl structures like the blood pressure drug valsartan are now often made this way.

In previous work, the Burke lab showed that the reaction could be made more convenient by using a specific type of boronate salt which can be easily added and removed from a molecule, and generally produces derivatives that are stable long-term. They then found that these salts can bind to silica and will only be released in the presence of the solvent tetrahydrofuran. So what they did was build a setup that can run this reaction iteratively; at each step, you add another bit of the molecule; each bit has a halide at one end and a boronate salt at the other. This is a lot like an amino acid, which has an amine at one end and a carboxylic acid at the other, which can each react with other amino acids to form chains. Since the molecule bits are shelf-stable, conceivably you could load a machine with a library of commonly used "puzzle pieces" (which you probably bought from a specialty chemicals manufacturer like Sigma-Aldrich or EMD) and assemble them, then wash off the finished product in THF. The yields demonstrated thus far are...not great, but the idea that it can run automated means that it could brute-force some syntheses and allow for the production of complex molecules from more common starting materials. It's a major advance in synthetic organic chemistry, but it's not so much a universal printer as more like an early mechanical printing press, where you still need to provide the type blocks and set the letters yourself.

Boxing has long been associated with a form of CTE called 'Dementia Pugilistica' (literally Boxer's Dementia), which manifests as Parkinsonism (and Dementia).

The etiology of 'Normal' Parkinsons and Dementia Pugilistica are almost certainly different, but at many stages they look similar enough that it's probably fair to say that boxing does essentially cause Parkinsons.

Nicotine is only distantly related structurally to the vitamin nicotinic acid (aka vitamin B3 or niacin). While nicotinic acid is an intermediate in tobacco's biosynthesis of nicotine, the final nicotine molecule also has an N-methylpyrrolidine ring not present in the vitamin. Nicotinic acid is the active form of vitamin B3, but the amide derivative (nicotinamide, as the parent notes) is also a bioavailable form, as it is converted in the body to nicotinic acid. Nicotinic acid is not named for a direct biological relationship to nicotine, but rather a synthetic chemical relationship. Nicotinic acid was first prepared synthetically by reacting nicotine with nitric acid; it was only later that nicotinic acid was isolated from biological systems, and was eventually found to be essential in the prevention of pellagra.

The physiological effects of nicotine are for the most part not due to its similarity with the vitamin niacin, but because it can bind to and activate a certain type of acetylcholine neuronal receptor: that is to say it mimics a neurotransmitter. Notably, nicotine does not bear much structural similarity to acetylcholine, but its agonist activity at these particular receptors is an identifying property of their type, to the point where they are called nicotinic acetylcholine receptors.

I don't know- I went looking for an MSDS for a modern firefighting foam, and the composition listed is:

Polyethylene glycol: 2.5-10%
Other components below reportable levels: Greater than 90%

Now, this is for Ansul-3 Fluoroprotein foam concentrate. It definitely contains some sort of fluorinated compound (fluoroprotein foam agents are at least known to contain a fluorinated surfactant and hydrolyzed protein); the MSDS has absolutely no mention of what it is. In the Environmental Handling section, all it says is "An environmental hazard cannot be excluded in the event of unprofessional handling or disposal." Nothing about how fluorinated surfactants are persistent environmental contaminants or can cause kidney damage in high doses. It is simply written like innocuous polyethylene glycol is the only component. I've seen material safety data sheets for shampoo that have far more information.

Now, in the specific case covered by the research paper, the "unknown compounds" aren't really that mysterious. They're all either metabolites, chemical precursors, or close chemical relatives (if you're making some some sort of octane derivative, you can expect some hexane to be in there too). And they're all given as 0.1%-1% of the main PFOS surfactant; certainly chemical manufacturers need to exert better control over their processes, minimize byproducts, perform long-term safety studies, etc. And that goes double for anyone making halogenated organic compounds, which now have a substantial record of turning out to be accumulative toxins. But I think if you look at many common manufactured products at trace levels with tandem mass spec, you're going to find some compounds that aren't in the literature.

No, the centaur object Chariklo (an icy asteroid between Saturn and Uranus) was recently discovered (2013) to have a set of rings, and a few other objects in that size range are suspected to.

That should actually be that Kepler-444 is of the same type as Alpha Centauri B, the smaller secondary star in that system. The primary star in Alpha Centauri is a G dwarf (yellow) like our sun.