Click and Drag is the worst... (Score 1)

I've noticed that holding down a mouse button and moving the mouse around at the same time cause the most discomfort. This becomes a problem mainly in games. This type of movement is almost constant while playing Quake or Ultima Online. After I Quit Playing Ultima Online all my wrist probelms cleared up.

One other thing I've tried that seems to help the pain(but slows me down quite a bit) is to use a track ball with two hands one for the ball the other for the buttons.