Manipulative People (Score 1)

So what about manipulative people that are known to use people as "tools." Does their manipulation activate any other regions of their brains in addition to tool use (other than the speech, body language, etc areas required to use such a tool)? Do they think of the person that they are trying to use as just a complex tool with a complex interface, or as something more? Do they have empathy for the person in that moment of manipulation? I think that the most severe and antisocial manipulators probably do treat people just like tools or (non-physical) extensions of their own bodies. Do we all think like that when we are trying to get something we want from someone, or is it more balanced with our feelings of empathy?