GarryFre writes "Neurological researchers at Rush University Medical Center have found a new therapeutic target that can potentially lead to a new way to prevent the progression of Alzheimer's disease. The target called neutral sphingomyelinase (N-SMase) is a protein which, when activated, can cause a chain of reactions in the cell leading to neuronal death and memory loss. Already a substance has been found that shows some promise in halting the progression of the disease."

An anonymous reader writes "After showcasing Quake Wars: Ray Traced a few years ago, Intel is now showing their latest graphics research project using Wolfenstein game content. The new and cool special effects are actually displayed on a laptop using a cloud-based gaming approach with servers that have an Intel Knights Ferry card (many-core) inside. Their blog post has a video and screenshots."

sk8pmp writes with news that iFixit, a website known for Apple gadget teardowns and repair guides, is expanding into the game console market, launching a series of troubleshooting and repair guides to help gamers fix their own machines. They're also starting to sell replacement parts and the tools necessary to work on them. "Right now there are repair guides for 24 gaming consoles, including 206 repairs and upgrades. Some of these fixes deal with major issues, such as the infamous Red Ring of Death from the Xbox 360, but others are simpler. For instance, right now there is no easy way to clean out the fans inside your console. 'I think this is probably the number one cause of overheating these days now that manufacturers have mostly gotten their act together,' Wiens said. 'This is routine maintenance, and it's mind-boggling that the manufacturers don't provide people with an easy way to open the case up and blow it out.' You'll also learn how to replace broken LCD screens on your portables, replace the motherboard on your PlayStation 3, and do just about anything else you might want to do to these systems, from the simple to the harrowing."

Apparently the destruction of the second Death Star has stretched the Galactic Empire's coffers so thin that Lord Vader himself is robbing banks. From the article: "Impotent Rebel Alliance security forces tell Newsday (paywall) that Vader marched into a Chase bank in Setauket around 11:30 a.m. today. Brandishing a completely unnecessary handgun — as he had the power to choke the oxygen out every teller's throat — the fallen Jedi demanded cash."

blackbearnh writes "Imagine that your data center was in the most geographically remote location in the world. Now imagine that you can only get to it 4 months of the year. Just for fun, add in some of the most extreme weather conditions in the world. That's the challenge that faces John Jacobsen, one of the people responsible for making sure that the data from the IceCube Neutrino Observatory makes it all the way from the South Pole to researchers across the world. In an interview recorded at OSCON, Jacobsen talks about the problems that he has to face (video), which includes (surprisingly) keeping the data center cool. If you're ever griped because you had to haul yourself across town in the middle of the night to fix a server crash, this interview should put things in perspective."

Whether they annoy you or fulfill your nerdy collection habit, achievements have spread across the gaming landscape and are here to stay. The Xbox Engineering blog recently posted a glimpse into the creation of the Xbox 360 achievement system, discussing how achievements work at a software level, and even showing a brief snippet of code. They also mention some of the decisions they struggled with while creating them: "We are proud of the consistency you find across all games. You have one friends list, every game supports voice chat, etc. But we also like to give game designers room to come up with new and interesting ways to entertain. That trade-off was at the heart of the original decision we made to not give any indication that a new achievement had been awarded. Some people argued that gamers wouldn't want toast popping up in the heat of battle and that game designers would want to use their own visual style to present achievements. Others argued for consistency and for reducing the work required of game developers. In the end we added the notification popup and its happy beep, which turned out to be the right decision, but for a long time it was anything but obvious."

baronvoncarson tips news that today Valve released an updated version of Alien Swarm, a popular Unreal Tournament 2004 total conversion mod. The creators of the mod were hired by Valve, and they've helped turn it into a stand-alone game running on the Source engine. Valve is also releasing the code base for Alien Swarm and an SDK. The game is available for free on Steam.

coondoggie writes NASA is working on some difficult renovations to reinvigorate its 70-meter-wide 'Mars antenna.' The antenna, a key cog in NASA's Deep Space Network, needs about $1.25M worth of what NASA calls major, delicate surgery. The revamp calls for lifting the antenna — about 4 million kilograms of finely tuned scientific instruments — to a height of about 5 millimeters so workers can replace the steel runner, walls and supporting grout."