Zorglub writes "Two prostate cancer patients who had been told their condition was inoperable are now cancer-free as the result of an experimental therapy, the Mayo Clinic in Rochester announced Friday. 'Cancer has a propensity for turning off T cells. Dr. Allison hypothesized that if you block the off-switch, T cells will stay turned on and create a prolonged immune response. Dr. Kwon, then at NIH, demonstrated that CTLA-4 blockage could be used to treat aggressive forms of prostate cancer in mice. There was one limitation to that concept — the worry that by simply leaving all the T cells on there may not be enough response aimed at the tumor. Dr. Kwon called Dr. Allison and designed the trial together. The idea: use androgen ablation or hormone therapy to ignite an immune approach — a pilot light — and then, after a short interval of hormone therapy, introduce an anti-CTLA-4 antibody that acts like gasoline to this pilot light and overwhelms the cancer cells.' After the treatment, the patients' tumors shrunk to such a degree that they could be successfully removed."

Alienkillerrace writes "The open sourced, freeware FPS game Alien Arena 2009 has been released (Windows and Linux). The improvements to the game engine are very significant, and have surely raised the bar for free games of this genre. All surfaces in the game are now rendered using GLSL, not only improving the visual quality, but the performance as well. Interesting new effects like post-process distortions using GLSL have been implemented, as well as light volumes, better per-pixel lighting (reminiscent of UT3), and shaded water. Equally notable is that the sound system has been completely rewritten using OpenAL, allowing for effects such as Doppler, and adding Ogg Vorbis support. The game is free to play and available for download on its official website. It has a stats system and a built-in IRC client in its front-end game browser."

theodp writes "Slate's Farhad Manjoo had high hopes for using the Kindle DX — Amazon's new large-screen e-reader — to read newspapers. A good first effort, says Manjoo, who concludes that for now newsprint still beats the $489 Kindle. While he has issues with latency, what he really misses relates to graphic design. The Kindle presents news as a list, leaving a reader to guess which pieces are most important to read. Newspapers, by contrast, opine on the importance of the day's news using easy-to-understand design conventions — important stories appear on front pages, with the most important ones going higher on the page and getting more space and bigger headlines. Also, because of its overnight delivery model, Manjoo gripes that the Kindle suffers from a lack of timeliness, making it not even as good as a smartphone."

Neil H. writes "The White House's Human Space Flight Plans blue-ribbon panel (the 'Augustine panel') has posted the material from their first public meeting on the future of NASA's spaceflight program, which was held on Wednesday. NASA officials presented their Ares I rocket plans and their belief that they can work around its design flaws, with projected development costs ballooning to $35 billion. The panel also heard several alternative proposals, such as adapting already-existing EELV and SpaceX rockets to carry crew to orbit; these proposals would have better safety margins than the Ares I, be ready sooner, and cost NASA less than $2 billion to complete, but are politically unattractive."

mikesd81 notes a press release on the EFF website that begins "The Obama Administration's decision to support Bush-era concealment policies has forced the Electronic Frontier Foundation (EFF) and Public Knowledge (PK) to drop their lawsuit about the proposed Anti-Counterfeiting Trade Agreement (ACTA). Federal judges have very little discretion to overrule Executive Branch decisions to classify information on 'national security' grounds, and the Obama Administration has recently informed the court that it intends to defend the classification claims originally made by the Bush Administration. ... Very little is known about ACTA, currently under negotiation between the US and more than a dozen other countries, other than that it is not limited to anti-counterfeiting measures. Leaked documents indicate that it could establish far-reaching customs regulations governing searches over personal computers and iPods. Multi-national IP corporations have publicly requested mandatory filtering of Internet communications for potentially copyright-infringing material, as well as the adoption of 'Three Strikes' policies requiring the termination of Internet access after repeat allegations of copyright infringement, like the legislation recently invalidated in France. Last year, more than 100 public interest organizations around the world called on ACTA country negotiators to make the draft text available for public comment."

Rock, Paper, Shotgun notes the kickoff of a new Discovery channel series called Rise of the Videogame. Blogger John Walker discusses the show, which just began last week, with an eye towards its research rigor and friendliness to the subject matter. He comes away fairly impressed, both by the topics covered and the casting. Along with games industry luminaries like Nolan Bushnell and Al Alcorn, they chat with folks like Steve Russell (of Spacewar! fame) and Smartbomb author Heather Chaplin. "A little visually overwrought with its montage footage of real-world conflict, it's otherwise a solid, informative and supremely well 'cast' documentary. If you've read around the subject, it won't tell you anything new. But it's fantastic to hear the stories from the people themselves. Episode 2 is very sensibly about the rise of Mario, next Wednesday."

macinrack writes to tell us that Defense Secretary Donald Rumsfeld, architect of the unpopular war in Iraq, intends to resign after six stormy years at the Pentagon. Officials said Robert Gates, former head of the CIA, would replace Rumsfeld.

Juha-Matti Laurio writes "Several vulnerabilities are fixed in version Firefox 1.5.0.2, which was released on Thursday. In addition to security patches Firefox now includes some stability enhancements and, as expected, includes native support for Apple Computer's Macs with Intel processors. Secunia has a detailed advisory about vulnerabilities fixed with this release."

prostoalex writes "Boosted by government purchases and SCO UNIX replacements, Linux grew by 27.1% in China in 2005 and generated $11.8 mln for the companies involved."