I'm rated troll now.
But on topic,
1. yes, samples come from somewhere but they don't escape to anywhere important if you crash on an isolated island. They do if you crash in Kansas. Or drop the sample box on the runway.
3. There's plenty enough people in the mid-west for an escaped bug to spread through. And isn't the point of a secure Level 5 lab to make people -safer-?
4. People will be expected to -live- in Kansas and drive to work. (Thereby radically increasing the chance of spreading bugs, btw.) No one will be expected to live full time on Dr. No's Pacific island. They will do rotations and live someplace where they want to be.
5. No, you didn't.
Isolated island good. Farmer's field in Kansas, bad.