Agree about the lack of nuance in public policy. However, I agree with the original poster. Ending the "Schedule 1" classification for all substances needs to happen. It should be up to pharmaceutical researchers and (ultimately) doctors to determine what drugs are useful for what patients, not law makers. Of course there are downsides to drugs. There are big downsides to most existing "Schedule 2" drugs, but doctors are allowed to prescribe them. There are potential downsides to ALMOST EVERYTHING, but that doesn't mean there should be blanket prohibitions on everything with a downside. Most "Schedule 1" drugs should really be in "Schedule 2" but if medical professionals want to DO BASIC RESEARCH or prescribe them to patients, there should be a way, which should include some strict regulations for transparency and accountability. When it comes to "street drugs" (of which many, like Fentanyl, one of the worst, are already Schedule 2) if there were a legal way for addicts to obtain them (that doesn't enrich unscrupulous doctors) combined with accessible treatment programs, it would create a badly needed "pressure release valve" in our society, and the solution already exists: see Portugal. Accidental overdose deaths would (largely) become a thing of the past, cases of drug-use-associated communicable diseases would plummet, and getting people into treatment programs becomes a lot easier when addicts are left with only the (medical) problem of being an addict, and not the (legal) problem of felony charges.
The whole "If it's legal people will think it's safe!" argument doesn't hold water. We are literally *surrounded* by unsafe things. Most of those things are labeled as dangerous, but we can all obtain them, usually easily. One of the most dangerous drugs is ethanol, and that's mostly because of its widespread use and cultural significance. Heroin is never going to have that kind of widespread use, and as we've seen in Portugal, smart laws make the problem of heroin addiction (and a number of its knock-on-effects) easier to solve, not harder. So labels and ACCURATE education about drugs (which is chief among the failures of "The War on Drugs") more-or-less solves that problem. Will people still do stupid things and get addicted? Of course. Will there still be unscrupulous people who will take advantage of vulnerable populations? You bet. But at least public policy won't be egging them on and literally creating the black markets where they can thrive.
I haven't even scratched the surface here, in terms of how much the "War on Drugs" has harmed the people of planet Earth, and how much ending it will help us, but suffice to say that most of it (like most wars) has been driven by emotion, politics and vested interest, not logic, science and good will.