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Comment In the case of doctors... (Score 5, Insightful) 174

The shortage of doctors in the US may be, in part, to blame for their long hours and burnout. Their professional organizations have limited the number of medical school and residency slots, which partly explains how they're paid about twice as much as those in other developed countries. Given that a large majority of freshmen entering US universities have pre-med aspirations, there is no lack of potential doctors in the US. More reading here:

The problem of doctors’ salaries
https://www.politico.com/agend...

Submission + - The beginning of the end for cannabis cultivation? (theregister.co.uk)

Uncle_Meataxe writes: Just when cannabis and hemp production is set to take off in many US states, some Berkeley scientists have harnessed yeast to produce some of the more sought-after cannabis chemicals. The Berkeley group modified yeast genes and inserted genes from bacteria and marijuana into brewers' yeast, Saccharomyces cerevisiae. "The economics look really good," senior member Jay Keasling said. "The cost is competitive or better than that for the plant-derived cannabinoids. And manufacturers don't have to worry about contamination – for example, THC in CBD – that would make you high."

Complete biosynthesis of cannabinoids and their unnatural analogues in yeast
https://www.nature.com/article...

Comment Re:So sorry you're stuck in traffic... (Score 1) 332

Sure, you'll need a shower at work if you ride any significant distance or in bad weather. And yeah, riding a bike is exercise. If you don't like sweating, it's probably not for you. I have friends who drive hours on the weekends to do wild adventures in the mountains, often involving some discomfort. Maybe it's hard to imagine, but adventure can be fun. That's the way I see it when I take off in bad weather. If you haven't been to Copenhagen or Amsterdam, you'd be surprised that the roads are *packed* with bike commuters, even when the weather gets a bit dicey.

And, not sure where you live, but I've been riding 10,000 miles/year for 25 years, in three states, in lots of cities and places, and I've never had any motorist *try* to hit me. I usually favor the same thoroughfares that you'd take in a car (if they have bike lanes) because it's faster and more efficient. Residential streets can be more dangerous with people pulling out of driveways, kids running into the streets, etc.

Comment Re:So sorry you're stuck in traffic... (Score 1) 332

Yeah, I hear you. 95% humidity is a problem even when it's 26 C. That's part of the reason I moved to a less humid climate. But, I ride even when it's over 43 C (110 F) here (usually 20% humidity). It's surprisingly comfortable when it's really hot as the sweat evaporates immediately. For riding less than an hour, it's also not a problem well below freezing. You just have to have the right clothes. Of course, I have a place to shower on both ends.

Comment So sorry you're stuck in traffic... (Score 3, Informative) 332

... because I'm not. I've been commuting by bicycle for the last 20 years. It's like being on vacation while getting to work -- the best part of my day! It's a bit over 20 miles (33 km) each way so I'm on the bike for about two hours/day. What's great is that I get two hours of workout in per day for essentially one hour of time (it takes 30 minutes to drive each way). The thing most motorist don't understand is riding a bike is often faster than driving. On surface streets, it's almost always faster to ride a bike during commute hours. On average, cars go about 13 mph (21 kph) in cities, which is a very easy speed to ride a bike. Yeah, I live in California, but I've commuted year 'round in Michigan too, so there...

Comment Re:The history of taxonomy (systematics)... (Score 2) 79

You may like to tack some political agenda onto what systematists do but I can tell you that it happens regularly without any thought to environmentalism or politics. Take for example naming species of algae -- an inordinate amount of splitting has been done with species (and subspecies and varieties!). Can you imagine how such splitting could help stop development of *anything*? My experience is that biologists don't tend to do things like systematics for political reasons.

Comment The history of taxonomy (systematics)... (Score 4, Interesting) 79

This is an odd post for the Slashdot crowd as systematics is a somewhat esoteric field even among biologists. The truth is that there have always been wars between the "splitters" and the "lumpers," the former happily naming lots of new species while the latter arguing against such foolishness. The thing is that the only people who care about such nuances are the systematists themselves and maybe ecologists who are trying to use their naming system to classify ecosystems, etc. What I've found maddening is that systematists often seemed to care little about the definition of "species." If you have a continuum of organisms with slightly varying morphology, where do you draw species lines? Can they interbreed? Lots of basic biology ignored in the mad dash to name everything. It's a hard problem.

Comment While we're on the topic... (Score 1) 48

... another article regarding Roundup, Monsanto, and lax oversight by US EPA...

Internal EPA Documents Show Scramble For Data On Monsanto’s Roundup Herbicide
The documents raise questions about how and why regulators for years have failed to require robust testing on what is the world’s most widely-used weed killer. http://www.huffingtonpost.com/...

Comment Re:UW study contradicts... (Score 3, Interesting) 511

Interesting point, but the UCB report is not "pure BS." Actually, it's a pretty difficult problem to address and economists have been working on it for years. Like previous studies, it appears that the UW study has its own methodological problems. You probably quit reading before you got to this point in that seattleweekly.com post:

"Berkeley’s Reich did not return a phone call seeking comment, but in a memo released Monday he blasted the UW report, saying it was full of red flags.

Among other things, the UW study did not include multisite businesses in the study, which the UW researchers argued produced a cleaner data set but which Berkeley researchers said meant a huge portion of Seattle’s low-wage work force was left out of the study. Reich also notes that many of the UW team’s most dire conclusions fall outside what even highly critical research would suggest."

“The unlikely UW estimate of large negative employment effects likely results from the problems noted above. Their findings are not credible and drawing inferences from the report are unwarranted,” Reich wrote."

Comment More fluoride in your food since 2004... (Score 1) 314

Another reason the feds may be lowering the fluoride standard is that we're getting more in our food recently. In 2004 and 2005, EPA registered sulfuryl fluoride for control of insect pests in harvested foods such as cereal grains, dried fruits, nuts, cocoa beans, etc. Sulfuryl fluoride breaks down to fluoride when it is applied and can leave fluoride residues on treated food. More info here: http://www.epa.gov/pesticides/....

Comment Similar experience with Nexus 4 and Android 4.3 (Score 1) 179

After installing the OTA update from 4.2.2 > 4.3 (August 2013), my Nexus 4 wouldn't boot. A quick scan of the interwebs found that lots of people had the same problem. I could load Cyanogenmod (based on 4.2.2) or the stock Google 4.2.2 image but other attempts to load 4.3 did not work. Eventually, I shipped back to Google and they gave me a new phone.

Comment And, Seralini's response... (Score 2) 341

Here's the Seralini team response to FCT. Basically, Seralini is challenging them to also retract the Monsanto study (e.g., Hammond et al. 2004):

http://gmoseralini.org/professor-seralini-replies-to-fct-journal-over-study-retraction/

Professor Seralini replies to FCT journal over study retraction

Professor Gilles-Eric Séralini and his team have responded to the letter from A. Wallace Hayes, editor of Food and Chemical Toxicology (FCT), telling Prof Séralini that he intended to retract his study on NK603 maize and Roundup.

Here’s the retraction notice from Elsevier, the publisher of FCT: http://prn.to/1euTk2W
Response by Prof GE Seralini and colleagues to A. Wallace Hayes, editor of Food and Chemical Toxicology
28 Nov 2013

We, authors of the paper published in FCT more than one year ago on the effects of Roundup and a Roundup-tolerant GMO (Séralini et al., 2012), and having answered to critics in the same journal (Séralini et al., 2013), do not accept as scientifically sound the debate on the fact that these papers are inconclusive because of the rat strain or the number of rats used. We maintain our conclusions. We already published some answers to the same critics in your Journal, which have not been answered (Séralini et al., 2013).

Rat strain

The same strain is used by the US national toxicology program to study the carcinogenicity and the chronic toxicity of chemicals (King-Herbert et al., 2010). Sprague Dawley rats are used routinely in such studies for toxicological and tumour-inducing effects, including those 90-day studies by Monsanto as basis for the approval of NK603 maize and other GM crops (Sprague Dawley rats did not came from Harlan but from Charles-River) (Hammond et al., 2004; Hammond et al., 2006a; Hammond et al., 2006b).

A brief, quick and still preliminary literature search of peer-reviewed journals revealed that Sprague Dawley rats were used in 36-month studies by (Voss et al., 2005) or in 24-month studies by (Hack et al., 1995), (Minardi et al., 2002), (Klimisch et al., 1997), (Gamez et al., 2007).Some of these studies have been published in Food and Chemical Toxicology.

Number of rats, OECD guidelines

OECD guidelines (408 for 90 day study, 452 chronic toxicity and 453 combined carcinogenicity/chronic toxicity study) always asked for 20 animals per group (both in 1981 and 2009 guidelines) although the measurement of biochemical parameters can be performed on 10 rats, as indicated. We did not perform a carcinogenesis study, which would not have been adopted at first, but a long-term chronic full study, 10 rats are sufficient for that at a biochemical level according to norms and we have measured such a number of parameters! The disturbance of sexual hormones or other parameters are sufficient in themselves in our case to interpret a serious effect after one year. The OPLS-DA statistical method we published is one of the best adapted. For tumours and deaths, the chronology and number of tumours per animal have to be taken into account. Any sign should be regarded as important for a real risk study. Monsanto itself measured only 10 rats of the same strain per group on 20 to conclude that the same GM maize was safe after 3 months (Hammond et al., 2004).

The statistical analysis should not be done with historical data first, the comparison is falsified, thus 50 rats per group is useless

The use of historical data falsifies health risk assessments because the diet is contaminated by dibenzo-p-dioxins and dibenzofurans (Schecter et al., 1996), mercury (Weiss et al., 2005), cadmium and chromium among other heavy metals in a range of doses that altered mouse liver and lung gene expression and confounds genomic analyses (Kozul et al., 2008). They also contained pesticides or plasticizers released by cages or from water sources (Howdeshell et al., 2003). Historical data also come from rats potentially fed on GMOs, some animal pellets in the world do indicate that. All that corresponds to the contamination levels for which we have detected some effects in our treated rats versus appropriate controls.

2-year historical data mammary fibroadenoma rate from Charles River SD females ranged from 13 to 62% (Giknis, 2004). We obtain a lot less in our controls, the real comparators, a lot more in treated rats. This makes our results significant, like for deaths.

Double standards

A factual comparative analysis of the rat feeding trial by the Séralini’s group and the Monsanto trials clearly reveals that if the Séralini experiments are considered to be insufficient to demonstrate harm, logically, it must be the same for those carried out by Monsanto to prove safety. Basically, all previous studies finding adverse effects of GE crops have been treated by regulators with the attitude: only those studies showing adverse effects receive a rigorous evaluation of their experimental and statistical methods, while those that claim proof of safety are taken at face value. All studies that reported no adverse effects were accepted as proof of safety regardless of these manifest (but deemed irrelevant) deficiencies of their methods.

The review by (Snell et al., 2012) illustrates this issue. In the abstract, the authors state “Results from all the 24 studies [reviewed] do not suggest any health hazards [...]” – taking all those studies at face value. Yet in their review, the authors find numerous weaknesses of similar or greater severity [than those] raised for the Séralini group’s paper. For example, of the 24 studies they evaluated 16 (67% of all studies) did not mention using the isogenic line as control (interpreted as having not used them), many did not describe the methods in any detail, and according to the reviewers had other deficiencies too.

FCT should retract the Hammond et al. paper on Roundup tolerant maize for all these reasons, published for Monsanto’s authorization, or consider that each of these papers is part of the scientific debate.

References

Gamez, R., Noa, M., Mas, R., Mendoza, N., Pardo, B., Menendez, R., Perez, Y., Gonzalez, R.M., Gutierrez, A., Marrero, G., Goicochea, E., Garcia, H., Curveco, D., 2007. Long-term carcinogenicity of D-003, a mixture of high molecular weight acids from sugarcane wax, in Sprague Dawley rats: a 24 months study. Food Chem Toxicol 45, 2352-2358.

Giknis, M.L.A.a.C., C.B., 2004. Charles River Laboratories. Compilation of spontaneous neoplastic lesions and survival in Crl:CD (SD) rats from control groups.

Hack, R., Ebert, E., Leist, K.H., 1995. Chronic toxicity and carcinogenicity studies with the insecticide endosulfan in rats and mice. Food Chem Toxicol 33, 941-950.

Hammond, B., Dudek, R., Lemen, J., Nemeth, M., 2004. Results of a 13 week safety assurance study with rats fed grain from glyphosate tolerant corn. Food Chem Toxicol 42, 1003-1014.

Hammond, B., Lemen, J., Dudek, R., Ward, D., Jiang, C., Nemeth, M., Burns, J., 2006a. Results of a 90-day safety assurance study with rats fed grain from corn rootworm-protected corn. Food Chem Toxicol 44, 147-160.

Hammond, B.G., Dudek, R., Lemen, J.K., Nemeth, M.A., 2006b. Results of a 90-day safety assurance study with rats fed grain from corn borer-protected corn. Food Chem Toxicol 44, 1092-1099.

Howdeshell, K.L., Peterman, P.H., Judy, B.M., Taylor, J.A., Orazio, C.E., Ruhlen, R.L., Vom Saal, F.S., Welshons, W.V., 2003. Bisphenol A is released from used polycarbonate animal cages into water at room temperature. Environ Health Perspect 111, 1180-1187.

King-Herbert, A.P., Sills, R.C., Bucher, J.R., 2010. Commentary: update on animal models for NTP studies. Toxicol Pathol 38, 180-181.

Klimisch, H.J., Deckardt, K., Gembardt, C., Hildebrand, B., Kuttler, K., Roe, F.J., 1997. Long-term inhalation toxicity of N-vinylpyrrolidone-2 vapours. Studies in rats. Food Chem Toxicol 35, 1041-1060.

Kozul, C.D., Nomikos, A.P., Hampton, T.H., Warnke, L.A., Gosse, J.A., Davey, J.C., Thorpe, J.E., Jackson, B.P., Ihnat, M.A., Hamilton, J.W., 2008. Laboratory diet profoundly alters gene expression and confounds genomic analysis in mouse liver and lung. Chem Biol Interact 173, 129-140.

Minardi, F., Belpoggi, F., Soffritti, M., Ciliberti, A., Lauriola, M., Cattin, E., Maltoni, C., 2002. Results of long-term carcinogenicity bioassay on vinyl acetate monomer in Sprague-Dawley rats. Ann N Y Acad Sci 982, 106-122.

Séralini, G.E., Clair, E., Mesnage, R. Gress, S., Defarge, N. Malatesta, M. Hennequin, D. Spiroux de Vendômois, J. (2012) Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize. Food and Chem. Tox. 50:4221-4231

Séralini, G.E., Mesnage, R., Defarge, N., Gress, S., Hennequin, D., Clair, E., Malatesta, M., Spiroux de Vendômois, J. (2013) Answers to critics: why there is a long term toxicity due to NK603 Roundup-tolerant genetically modied maize and to a Roundup herbicide. Food and Chem. Tox. 53:461-468

Schecter, A.J., Olson, J., Papke, O., 1996. Exposure of laboratory animals to polychlorinated dibenzodioxins and polychlorinated dibenzofurans from commerical rodent chow. Chemosphere 32, 501-508.

Snell, C., Bernheim, A., Berge, J.B., Kuntz, M., Pascal, G., Paris, A., Ricroch, A.E., 2012. Assessment of the health impact of GM plant diets in long-term and multigenerational animal feeding trials: a literature review. Food Chem Toxicol 50, 1134-1148.

Voss, C., Zerban, H., Bannasch, P., Berger, M.R., 2005. Lifelong exposure to di-(2-ethylhexyl)-phthalate induces tumors in liver and testes of Sprague-Dawley rats. Toxicology 206, 359-371.

Weiss, B., Stern, S., Cernichiari, E., Gelein, R., 2005. Methylmercury contamination of laboratory animal diets. Environ Health Perspect 113, 1120-1122.

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