Just design it to be standards compliant, and let the browsers that can't follow the standards fail, hopefully gracefully.
But what is a standard? Is it what some organization like Acid3 decides? Or is it what most browsers support? The reason that IE6 didn't fall for lack of standards was because it was the standards. IE6, the dominant browser for quite a while, was the most standard browser in existence because it was the dominant browser.
Pissing off 4chan is probably the worst thing you can do on the Internet.
I disagree: http://xkcd.com/591/
All seems condemned in the long run to approximate a state akin to Gaussian noise. -- James Martin