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Description

ESMFold2 builds upon its predecessor, ESMFold, by establishing a new benchmark in single-sequence structure prediction and facilitating the creation of novel functional proteins via exploration of the latent space within the ESMC model. This advanced model is capable of forecasting high-resolution, all-atom 3D structures of biomolecular complexes straight from the amino acid sequence, and it allows for the incorporation of multiple sequence alignments to improve accuracy on difficult targets. Tailored for predicting structures through both sequence and structure modalities, it employs ESM representations that drive a series of looped folding layers while a diffusion model translates pairwise representations into atomic-resolution outcomes. ESMFold2 excels in predicting protein structures from amino acid sequences, providing detailed structural data, including precise all-atom coordinates for both backbone and side chains, along with confidence metrics and optional distogram predictions for in-depth structural evaluation. Furthermore, its innovative approach enhances the understanding of protein folding dynamics and functional implications, making it a valuable tool for researchers in the field.

Description

Photo51 serves as an online molecular biology platform tailored for the design and examination of DNA and protein sequences. This comprehensive suite facilitates various tasks such as plasmid design, automated feature annotation, virtual cloning, PCR primer development, and simulating agarose gel electrophoresis. Users have the capability to import sequence files and utilize a built-in genome browser to navigate reference genomes, analyze gene views, and export sequences for their projects. Other features offered include the design of guide RNA with PAM visualization, pairwise and multiple sequence alignment, viewing of Sanger chromatograms, protein alignment, and reverse translation capabilities. Additionally, Photo51 fosters collaboration through shared team workspaces and maintains a version history for ongoing projects. The open-access genome browser enhances the exploration of genomic data, while subscription options unlock further editing and analytical functionalities. This platform is specifically designed for researchers, educators, and teams in biotechnology engaged in molecular biology tasks, promoting a streamlined workflow for various scientific inquiries. Overall, Photo51 stands out as a versatile tool that supports the diverse needs of the molecular biology community.

API Access

Has API Yes 

API Access

Has API No 

Screenshots View All

Screenshots View All

Integrations

Biohub Yes 
Mira Yes 
Python Yes 

Integrations

Biohub No 
Mira No 
Python No 

Pricing Details

Free
Free Trial No 
Free Version Yes 

Pricing Details

€5/month
Academic access is €5/month; commercial use is €50/month.
Free Trial Yes 
Free Version Yes 

Deployment

Web-Based Yes 
On-Premises No 
iPhone App No 
iPad App No 
Android App No 
Windows No 
Mac No 
Linux No 
Chromebook No 

Deployment

Web-Based Yes 
On-Premises No 
iPhone App No 
iPad App No 
Android App No 
Windows Yes 
Mac Yes 
Linux No 
Chromebook No 

Customer Support

Business Hours No 
Live Rep (24/7) No 
Online Support Yes 

Customer Support

Business Hours No 
Live Rep (24/7) No 
Online Support Yes 

Types of Training

Training Docs Yes 
Webinars No 
Live Training (Online) No 
In Person No 

Types of Training

Training Docs Yes 
Webinars No 
Live Training (Online) Yes 
In Person Yes 

Vendor Details

Company Name

Biohub

Founded

2016

Country

United States

Website

biohub.ai/models/esmfold2

Vendor Details

Company Name

Fearless League

Founded

2023

Country

Netherlands

Website

fearlessleague.com

Product Features

Product Features

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Alternatives

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