The world's first routine vaccine programme against malaria has started in Cameroon, in a move projected to save thousands of children's lives across Africa. From a report: The symbolic first jab was given to a baby girl named Daniella at a health facility near Yaounde on Monday. Every year 600,000 people die of malaria in Africa, according to the World Health Organization (WHO). Children under five make up at least 80% of those deaths. Cameroon is offering the RTS,S vaccine free of charge to all infants up to the age of six months old.

Patients require a total of four doses. Health officials say these will be given at the same time as other routine childhood vaccines to make it easier for parents. It comes after successful pilot campaigns in Kenya, Ghana and Malawi - where the vaccine caused a 13% drop in malaria deaths in children of eligible age, says Unicef. The jab is known to be effective in at least 36% of cases, according to US researchers, meaning it could save over one in three lives. While the rollout is undoubtedly a relief and a life-saver, its relatively low efficacy rate means that it is not a "silver bullet," argues Willis Akhwale at End Malaria Council Kenya.

It's been 25 years since a small studio in Dallas recast the ancient world through the prism of a real-time strategy game. From a report: Age of Empires has echoed Monk wololos about our homes ever since: Parents believed that their kids were learning history; kids believed that they were gaming surreptitiously. And veteran players know that both were right. Yet Age of Empires did not always receive the love it does today. The rise of the Xbox saw PC gaming take a back seat for Microsoft: Communities like AoE's were left to fend for themselves.

In a very real way, it was the passion of these obsessives that led to Microsoft's renewed attention and the release of the franchise's latest entry, 2021's Age of Empires IV. All the games continue to receive updates or DLCs. Age of Empires games are headed for Xbox and mobile devices, complete with cross-play so console gamers can get their hands on the RTS classic and play with their PC-loving friends. Also, Age of Mythology is finally getting a definitive edition. Age IV is building momentum, too, with an anniversary edition crowning a year of updates designed to woo players who found it a tad stripped back at launch. AoE is now a point of real-time-strategy pride and a shining jewel in Microsoft's roster.

Children across much of Africa are to be vaccinated against malaria in a historic moment in the fight against the deadly disease. From a report: Malaria has been one of the biggest scourges on humanity for millennia and mostly kills babies and infants. Having a vaccine -- after more than a century of trying -- is among medicine's greatest achievements. The vaccine -- called RTS,S -- was proven effective six years ago. Now, after the success of pilot immunisation programmes in Ghana, Kenya and Malawi, the World Health Organization says the vaccine should be rolled out across sub-Saharan Africa and in other regions with moderate to high malaria transmission. Dr Tedros Adhanom Ghebreyesus, director-general of the WHO said it was "a historic moment." "The long-awaited malaria vaccine for children is a breakthrough for science, child health and malaria control." Using the vaccine on top of existing tools "could save tens of thousands of young lives each year," he said.

An anonymous reader shares an excerpt from a Science Magazine blog, written by Derek Lowe: Excellent news today: we have word of the most effective malaria vaccine yet discovered. A year-long trial in Burkina Faso has shown 77% efficacy, which is by far the record, and which opens the way to potentially relieving a nearly incalculable burden of disease and human suffering.

This new vaccine (R21) uses a circumsporozoite protein (CSP) antigen -- that's a highly conserved protein of the parasite, involved in several functions as the parasite makes the move from mosquito to human and into different human tissues such as the salivary glands. This has been a vaccine ingredient before, such as in the RTS,S vaccine (the first one ever licensed), but R21 has a much higher proportion of CSP assembled into a virus-like particle. It also uses the exact same adjuvant from Novavax (Matrix-M) that they are using in their coronavirus vaccine -- you can't keep a good adjuvant down, and this Chilean-soapbark-based one seems to really kick the immune system up under all circumstances.

The higher-adjuvant cohort showed 77% vaccine efficacy, and the lower-adjuvant one showed 74% with (as you'd expect) overlapping confidence intervals. The first group had significantly higher antibody levels, though, and they're currently doing an additional year of follow-up to see how long the protection lasts and if these doses differentiate themselves. The antibody levels at the one-year mark in both groups were significantly higher than with the RTS,S vaccine, and in particular, antibodies against the repeat section in the middle of the circumsporozite protein seemed to correlate strongly with protection. No safety problems so far. The team is now planning a larger Phase III at five different African site, with varying seasonality and malaria loads.

Age of Empires 2, a 21-year-old game, could well be having its best year ever. From a report: Since its HD re-release in 2013 the game has had a steady growth in average player count, but with the release of Age of Empires 2: Definitive edition last year and COVID-19 lockdowns inflating player counts across the industry, Age of Empires 2 is boasting totals that beat some very big-name games. It's now by far Steam's most popular RTS, with both the Definitive Edition and the 2013 HD Edition having higher player counts than closest competitor Company of Heroes 2. This year's big tournament boasted the largest Age of Empires 1v1 prize pool since 2002.

Last month, in April, the games' combined average player count was over 50,000 players. April 12 was the definitive edition's all-time player peak, and the combined total of the games was 59,995 players. That's well into the top 150 all-time peak player counts on Steam... for a 21-year-old game. The two games generally average higher player counts than popular free-to-play game War Thunder or industry darling Stardew Valley. They're on-par with the popular action RPG Path of Exile. Their average is nearly as many as perennially popular premium games like Civilization VI or Terraria. Both versions of Age of Empires 2 sit in the top 100 games on Steam, with the Definitive Edition sitting at #25. Combined, however, the Age of Empires community on average pushes up to the #15 spot -- or higher, on peak player count days.

An anonymous reader shares a report: The world's first vaccine against malaria will be introduced in three countries -- Ghana, Kenya and Malawi -- starting in 2018. The RTS,S vaccine trains the immune system to attack the malaria parasite, which is spread by mosquito bites. The World Health Organization (WHO) said the jab had the potential to save tens of thousands of lives. But it is not yet clear if it will be feasible to use in the poorest parts of the world. The vaccine needs to be given four times -- once a month for three months and then a fourth dose 18 months later.

An anonymous Slashdot reader writes: "Amazon.com's first big-budget video game is like street basketball, except played in a mythological world where athletes are armed," reports the Los Angeles Times, adding "Wait, Amazon makes video games?" Indeed. Two weeks ago Amazon Game Studios held their first live "unboxing event", and PlayBreakaway.com is now accepting sign-ups for alpha playtesting of their new Twitch-optimized team-based title, promising a game "made by streamers, for streamers." ("Taunt every interception, celebrate every kill, and highlight your dominance with instant replays...")

"If you think about what makes games so fantastic, it's the experiences you have with your friends," explained one Amazon Games official, in an interview with the Times Friday. "A long time ago it was in arcades, then over local networks, then online and now you have Twitch and e-sports and modding and cosplay. They are all about shared experiences."

Twitter just began rolling out "new ways to control your experience," promising the two new features "will give you more control over what you see and who you interact with on Twitter." An anonymous Slashdot reader quotes a report from Wired UK: First up, notification settings will allow those using Twitter on the web or on desktop to limit the notifications they receive for @ mentions, RTs, and other interactions to just be from people they follow. The feature can be turned on through the notifications tab. Twitter is also expanding its quality filter -- also accessible through notifications. "When turned on, the filter can improve the quality of Tweets you see by using a variety of signals, such as account origin and behavior," the company's product manager Emil Leong said in a blog post.

In December 2015, the company changed its rules to explicitly ban "hateful conduct" for the first time, while back in February last year, Twitter's then-CEO Dick Costolo admitted the network needed to improve how it handled trolls and abuse. In a leaked memo he said: "I'm frankly ashamed of how poorly we've dealt with this issue during my tenure as CEO. It's absurd. There's no excuse for it. I take full responsibility for not being more aggressive on this front. It's nobody else's fault but mine, and it's embarrassing."
Meanwhile, the Twitter account of Wikipedia co-founder Jimmy Wales was hacked on Saturday.

Vigile writes: The future of graphics APIs lies in DirectX 12 and Vulkan, both built to target GPU hardware at a lower level than previously available. The advantages are better performance, better efficiency on all hardware and more control for the developer that is willing to put in the time and effort to understand the hardware in question. Until today we have only heard or seen theoretical "peak" performance claims of DX12 compared to DX11. PC Perspective just posted an article that uses a pre-beta version of Ashes of the Singularity, an upcoming RTS utilizing the Oxide Games Nitrous engine, to evaluate and compare DX12's performance claims and gains against DX11. In the story we find five different processor platforms tested with two different GPUs and two different resolutions. Results are interesting and show that DX12 levels the playing field for AMD, with its R9 390X gaining enough ground in DX12 to overcome a significant performance deficit that exists using DX11 to the GTX 980.

An anonymous reader writes: When Supreme Commander was released 8 years ago, it redefined the RTS genre, with its real-time strategic zoom and its epic battles involving several thousands of units at once, while bringing a whole generation of PCs to their knees. Today an article revisits the process of rendering a frame of the game by reverse-engineering the API calls made to the GPU. All the techniques and algorithms are explained in detail, many of them still used in current video games.

Zothecula writes: Small airports are often in a no-win situation. They don't have much traffic because they don't have an adequate tower system, and they don't have an adequate tower system because they don't have much traffic. That could be about to change, with the opening of the world's first remotely operated air-traffic control system in Sweden. Thanks to the Remote Tower Services (RTS) system, the first plane landed last week at Örnsköldsvik Airport, but it was controlled from the LFV Remote Tower Centre 123 km (76 mi) away in Sundsvall.

wabrandsma points out this Reuters story, according to which: Apple is not able to launch its new smartwatch in Switzerland until at least the end of this year because of an intellectual property rights issue, Swiss broadcaster RTS reported on its website. The U.S. tech giant cannot use the image of an apple nor the word 'apple' to launch its watch within Switzerland, the home of luxury watches, because of a patent from 1985, RTS reported, citing a document from the Swiss Federal Institute of Intellectual Property.

New submitter MorgyTheMole writes Porting C++/OpenGL based games using Emscripten and WebGL has been an approach pushed by Mozilla for some time now. Games using the technology are compatible with most modern browsers and require no separate install. We've seen Epic Games demonstrate UnrealEngine 4 in browser as well as Unity show off a variety of games. Now as the technology matures, indie devs are looking to get into the mix, including this near one-to-one port of E McNeill's Auralux, a simplified RTS game, from Android and iOS. (Disclosure: I am a programmer who worked on this title.)

An anonymous reader writes So I, like many people, want to make my own game. Outside of MATLAB, Visual Basic, and LabVIEW I have no real programming experience. I initially started with Ruby, but after doing my homework decided that if I ever wanted to progress to a game that required some power, I would basically need to learn some form of C anyway. Further digging has led me to C#. The other parts of game design and theory I have covered: I have ~8 years of CAD modeling experience including Maya and Blender; I have a semiprofessional sound studio, an idie album on iTunes, and am adept at creating sound effects/music in a wide variety of programs; I'm familiar with the setbacks and frustration involved with game development — I beta tested DotA for 9ish years; I already have my game idea down on paper (RTS), including growth tables, unit types, unit states, story-lines, etc. I've been planning this out for a year or two; I will be doing this on my own time, by myself, and am prepared for it to take a couple years to finish. The reason for listing that stuff out, is that I want people to understand that I know what I'm getting myself in to, and I'm not trying to put out a not-so-subtle "help me make a game for free lol" type of post. With all of that said, where is a good place to start (i.e., recommended books) for learning C# for game programming? I am familiar with object oriented programming, so that's a little bit of help. I'm not necessarily looking for the syntax (that part is just memorization), but more for the methodology involved. If anyone also has any suggestions for other books or information that deal with game development, I would love to hear that too. I know enough to understand that I really don't know anything, but have a good foundation to build on.

An anonymous reader points to this "This is an interesting interview with the creators of the High School Star League, an organization dedicated to furthering eSports as a viable hobby and even a career for children and young adults. The HSL has been active in the U.S. for a while but is now making a headway into Europe, where it's finding Counter-Strike is proving much more popular than RTS and MOBA games. There are a significant number of girls getting involved as well — as many as seven percent of competitors. It's a start, right?"

MojoKid writes "Blizzard has released a powerful new suite of tools for Starcraft 2 modders and developers that fundamentally change the nature of what's possible in the popular RTS game. Now, players can use the same architectural and graphics design toolsets that Blizzard has used internally to build new units, tilesets, and models. Furthermore, these tools are now available even with the Starcraft 2: Starter Edition kit. Critically, artists will now be able to incorporate images and effects designed in programs like 3ds Max, Photoshop, or other high-end particle systems. The exciting thing about these releases is that Starcraft 2's modding list is as interesting as the primary game, if not moreso. Fans have faithfully created adaptations of famous Starcraft maps, implemented entirely new rulesets that blend the old, micro-friendly playstyle of Starcraft with the modern engine, and even gone total conversion with Warcraft ported over into the SC2 game."

Nerval's Lobster writes "Last week, Microsoft announced that it would take a $900 million write-off on its Surface RT tablets. Although launched with high hopes in the fall of 2012, the sleek devices—which run Windows RT, a version of Windows 8 designed for hardware powered by the mobile-friendly ARM architecture—have suffered from middling sales and fading buzz. But if Microsoft decides to continue with Surface, there's one surefire way to restart its (metaphorical) heart: make it the ultimate bargain. The company's already halfway there, having knocked $150 off the sticker price, but that's not enough. Imagine Microsoft pricing the Surface at a mere pittance, say $50 or $75 — even in this era of cheaper tablets, the devices would fly off the shelves so fast, the sales rate would make the iPad look like the Zune. There's a historical precedent for such a maneuver. In 2011, Hewlett-Packard decided to terminate its TouchPad tablet after a few weeks of poor sales. In a bid to clear its inventory, the company dropped the TouchPad's starting price to $99, which sent people rushing into stores in a way they hadn't when the device was priced at $499. Demand for the suddenly ultra-cheap tablet reached the point that HP needed weeks to fulfill backorders. (Despite that sales spike, HP decided to kill the TouchPad; the margins on $99 obviously didn't work out to everyone's satisfaction.) In the wake of Microsoft announcing that it would take that $900 million write-down on Surface RT, reports surfaced that the company could have as many as six million units sitting around, gathering dust. Whether that figure is accurate—it seems more based on back-of-napkin calculations than anything else—it's almost certainly the case that Microsoft has a lot of unsold Surface RTs in a bunch of warehouses all around the world. Why not clear them out by knocking a couple hundred dollars off the price? It's not as if they're going anywhere, anyway."

onyxruby writes "In a move that will remind many of Apple in the '80s, Microsoft is going to start dumping Surface RT computers to educational institutions. In an effort to try to gain mindshare for their struggling Surface RT platform, Microsoft is giving away 10,000 Surface RTs to teachers through the International Society for Technology in Education. They're also preparing to offer $199 Surface RTs to K12 and higher education institutions. The strategy of flooding the educational market was quite successful for Apple. Unfortunately for Microsoft, today's computers require management and the Surface RT presents significant management challenges in terms of the inability to join the computer to a domain or available management tools."

mpthompson writes "Via RoboticsTrends' newsletter, RTS Lab in Tehran is developing Pars, which is an aerial rescue robot quadcopter designed to save potential drowning victims. The ship-based quadcopter responds instantly when alerted to potential victims in the ocean, locating them with thermal imaging sensors, and dispensing life preservers directly over them. The current prototype carries one life preserver, but they are working on a new model to carry three life preserver rings. Future models may dispense up to 15 self-inflating rings. A launching platform for use on ships has been designed, but more intriguing is an idea for a remote stand-alone launching platform. It's good to see innovative robot tech coming from a country that is not normally well covered in Western media."

Today Blizzard launched its first expansion to StarCraft 2, titled Heart of the Swarm. When initially developing StarCraft 2, Blizzard made the decision to split the game into three parts, each with a campaign as long as the original StarCraft. The initial release in 2010, Wings of Liberty, centered on the story of the Terrans. The newly-released Heart of the Swarm is focused on the Zerg. The final release, Legacy of the Void, will dedicate its campaign to the Protoss (and does not have a projected release timeframe yet). In addition to the new campaign, new units have been introduced for multiplayer and new maps have been added, which ought to shake things up in the competitive landscape. Blizzard has also made long-awaited improvements to the social system, including support for groups and clans.