An anonymous reader quotes a report from The Wall Street Journal, written by James Nestor: Breathing is a missing pillar of health, and our attention to it is long overdue. Most of us misunderstand breathing. We see it as passive, something that we just do. Breathe, live; stop breathing, die. But breathing is not that simple and binary. How we breathe matters, too. Inside the breath you just took, there are more molecules of air than there are grains of sand on all the world's beaches. We each inhale and exhale some 30 pounds of these molecules every day -- far more than we eat or drink. The way that we take in that air and expel it is as important as what we eat, how much we exercise and the genes we've inherited. This idea may sound nuts, I realize. It certainly sounded that way to me when I first heard it several years ago while interviewing neurologists, rhinologists and pulmonologists at Stanford, Harvard and other institutions. What they'd found is that breathing habits were directly related to physical and mental health.

Today, doctors who study breathing say that the vast majority of Americans do it inadequately. [...] But it's not all bad news. Unlike problems with other parts of the body, such as the liver or kidneys, we can improve the airways in our too-small mouths and reverse the entropy in our lungs at any age. We can do this by breathing properly. [...] [T]he first step in healthy breathing: extending breaths to make them a little deeper, a little longer. Try it. For the next several minutes, inhale gently through your nose to a count of about five and then exhale, again through your nose, at the same rate or a little more slowly if you can. This works out to about six breaths a minute. When we breathe like this we can better protect the lungs from irritation and infection while boosting circulation to the brain and body. Stress on the heart relaxes; the respiratory and nervous systems enter a state of coherence where everything functions at peak efficiency. Just a few minutes of inhaling and exhaling at this pace can drop blood pressure by 10, even 15 points. [...] [T]he second step in healthy breathing: Breathe through your nose. Nasal breathing not only helps with snoring and some mild cases of sleep apnea, it also can allow us to absorb around 18% more oxygen than breathing through our mouths. It reduces the risk of dental cavities and respiratory problems and likely boosts sexual performance. The list goes on.

Researchers from the University Hospital Zurich, ETH Zurich, Wyss Zurich and the University of Zurich have developed a machine that repairs injured human livers and keeps them alive outside the body for one week. ScienceDaily reports: Until now, livers could be stored safely outside the body for only a few hours. With the novel perfusion technology, livers -- and even injured livers -- can now be kept alive outside of the body for an entire week. This is a major breakthrough in transplantation medicine, which may increase the number of available organs for transplantation and save many lives of patients suffering from severe liver disease or a variety of cancers. Injured cadaveric livers, initially not suitable for use in transplantation, may regain full function while perfused in the new machine for several days. The basis for this technology is a complex perfusion system, mimicking most core body functions close to physiology. The corresponding study was published in the journal Nature Biotechnology.

The inaugural study shows that six of ten perfused poor-quality human livers, declined for transplantation by all centers in Europe, recovered to full function within one week of perfusion on the machine. The next step will be to use these organs for transplantation. The proposed technology opens a large avenue for many applications offering a new life for many patients with end stage liver disease or cancer.

An anonymous reader quotes a report from ScienceDaily: In a University of California, Irvine-led study, researchers found evidence that fasting affects circadian clocks in the liver and skeletal muscle, causing them to rewire their metabolism, which can ultimately lead to improved health and protection against aging-associated diseases. The study was published recently in Cell Reports. The research was conducted using mice, which were subjected to 24-hour periods of fasting. While fasting, researchers noted the mice exhibited a reduction in oxygen consumption (VO2), respiratory exchange ratio (RER), and energy expenditure, all of which were completely abolished by refeeding, which parallels results observed in humans.

"The reorganization of gene regulation by fasting could prime the genome to a more permissive state to anticipate upcoming food intake and thereby drive a new rhythmic cycle of gene expression. In other words, fasting is able to essentially reprogram a variety of cellular responses. Therefore, optimal fasting in a timed manner would be strategic to positively affect cellular functions and ultimately benefiting health and protecting against aging-associated diseases." This study opens new avenues of investigation that could ultimately lead to the development of nutritional strategies to improve health in humans.

ananyo writes "Transplanting tiny 'liver buds' constructed from human stem cells restores liver function in mice, researchers have found. Although preliminary, the results offer a potential path towards developing treatments for the thousands of patients awaiting liver transplants every year. The liver buds, approximately 4 mm across, staved off death in mice with liver failure, the researchers report this week in Nature (abstract.). The transplanted structures also took on a range of liver functions — secreting liver-specific proteins and producing human-specific metabolites. But perhaps most notably, these buds quickly hooked up with nearby blood vessels and continued to grow after transplantation."

Zothecula writes "In the quest to grow replacement human organs in the lab, livers are no doubt at the top of many a barfly's wish list. With its wide range of functions that support almost every organ in the body and no way to compensate for the absence of liver function, the ability to grow a replacement is also the focus of many research efforts. Now, for the first time, researchers have been able to successfully engineer miniature livers in the lab using human liver cells."

NIckGorton writes "Research is now underway in the US to seek FDA approval for an artificial liver. The Extracorporeal Liver Assist Device (ELAD) filters blood through a cartridge containing immortalized human liver cells with fiber tubes running through that allow the patients blood to interact with them. This allows the matrix of liver cells to perform both the metabolic (cleansing the blood of toxins/waste) and synthetic (producing albumin, clotting factors, etc) functions of the patient's failing liver. A small trial in China showed a statistically and clinically significant difference in 30 day survival with ELAD."