"The linked article is pretty much a press release, but it's still interesting to see the promise of exoskeletons starting to infiltrate the mass market," writes longtime Slashdot reader Baron_Yam. "These rigs cost $5,000, weigh only a few pounds, and go for multiple hours on a charge." Gizmodo reports: With the MO/GO exoskeleton hiking pants, a traipse through the mountains is becoming more mechanical, not to mention expensive. The MO/GO (short for "Mountain Goat") is a joint effort with established outdoor apparel makers Arc'Teryx and the tech startup Skip. Remember Samsung's exoskeleton pants concepts? These are kind of like that, though Skp and Arc'Teryx's first commercial product covers up all those glaring metal bits with an already-pricey pair of designer hiking pants. The MO/GO is supposed to push you 40% harder, according to the company. What does that mean in context? Fast Company rolled around in them for a hike and found the exoskeleton took a lot of weight off the knee, cushioned footfalls, and kicked the leg forward when tackling an incline. [...]

Two braces go into each leg, while the 3-hour power pack sits at the belt line just above your posterior. The MO/GO is a pair of Arc'teryx Gamma pants with cuffs to snap Skip's carbon fiber exoskeletal thighs onto the outside of each leg, which should impact your quadriceps and hamstring muscles. The companies claim each ligament weighs 2 pounds, with the pants in total clocking in at 7 pounds, but instead of adding weight the arms absorb the impact of each step, enough to make users feel "30 pounds lighter." [...] On Skip's site, you can see an internal look at how the motors spin every time the user raises their knee. The pants are supposed to have an on-board algorithm to handle stairs or a steep incline differently. You don't control it with an app either. There are three buttons on the pants: an on/off switch, as well as "less assistance" and "more assistance" toggles.

An anonymous reader shares a report: When someone loses part of a leg, a prosthetic can make it easier to get around. But most prosthetics are static, cumbersome, and hard to move. A new neural interface connects a bionic limb to nerve endings in the thigh, allowing the limb to be controlled by the brain. The new device, which is described today in Nature Medicine, could help people with lower-leg amputations feel as if their prosthesis is part of them. "When you ask a patient 'What is your body?' They don't include the prosthesis," says MIT biophysicist Hugh Herr, one of the lead authors on the study. The work is personal for him: he lost both his lower legs in a climbing accident when he was 17. He says linking the brain to the prosthesis can make it feel more like part of someone's anatomy, which can have a positive emotional impact.

Getting the neural interface hooked up to a prosthetic takes two steps. First, patients undergo surgery. Following a lower leg amputation, portions of shin and calf muscle still remain. The operation connects shin muscle, which contracts to make the ankle flex upward, to calf muscle, which counteracts this movement. The prosthetic can also be fitted at this point. Reattaching the remnants of these muscles can enable the prosthetic to move more dynamically. It can also reduce phantom limb pain, and patients are less likely to trip and fall. "The surgery stands on its own," says Amy Pietrafitta, a para-athlete who received it in 2018. "I feel like I have my leg back." But natural movements are still limited when the prosthetic isn't connected to the nervous system.

In step two, surface electrodes measure nerve activity from the brain to the calf and shin muscles, indicating an intention to move the lower leg. A small computer in the bionic leg decodes those nerve signals and moves the leg accordingly, allowing the patient to move the limb more naturally. "If you have intact biological limbs, you can walk up and down steps, for example, and not even think about it. It's involuntary," says Herr. "That's the case with our patients, but their limb is made of titanium and silicone." The authors compared the mobility of seven patients using a neural interface with that of patients who had not received the surgery. Patients using the neural interface could walk 41% faster and climb sloped surfaces and steps. They could also dodge obstacles more nimbly and had better balance. And they described feeling that the prosthetic was truly a part of their body rather than just a tool that they used to get around.

An anonymous reader quotes a report from The Guardian: Marc, 63, from Bordeaux, France, was diagnosed with the degenerative disease more than 20 years ago and had developed severe mobility problems, including balance impairments and freezing of gait. After receiving the implant, which aims to restore normal signaling to the leg muscles from the spine, he has been able to walk more normally and regained his independence. "I practically could not walk any more without falling frequently, several times a day. In some situations, such as entering a lift, I'd trample on the spot, as though I was frozen there, you might say," he said. "Right now, I'm not even afraid of the stairs any more. Every Sunday I go to the lake, and I walk around 6 kilometers [3.7 miles]. It's incredible."

The implant is yet to be tested in a full clinical trial. But the Swiss team, who have a longstanding program to develop brain-machine interfaces to overcome paralysis, hope that their technology could offer an entirely new approach to treating movement deficits in those with Parkinson's disease. "It is impressive to see how by electrically stimulating the spinal cord in a targeted manner, in the same way as we have done with paraplegic patients, we can correct walking disorders caused by Parkinson's disease," said Jocelyne Bloch, neurosurgeon and professor at the CHUV Lausanne University hospital, who co-led the work.

First, the team developed a personalized anatomical map of Marc's spinal cord that identified the precise locations that were involved in signaling to the leg to move. Electrodes were then implanted at these locations, allowing stimulation to be delivered directly into the spine. The patient wears a movement sensor on each leg and when walking is initiated the implant automatically switches on and begins delivering pulses of stimulation to the spinal neurons. The aim is to correct abnormal signals that are sent from the brain, down the spine, to the legs in order to restore normal movement. "At no point is [the patient] controlled by the machine," said Prof Eduardo Martin Moraud, of Lausanne University hospital. "It's just enhancing his capacity to walk." The study, published in Nature Medicine, found that the implant improved walking and balance deficits and when Marc's walking was analyzed it more closely resembled that of healthy controls than that of other Parkinson's patients. Marc also reported significant improvements in his quality of life.

An anonymous reader quotes a report from Scientific American: Barred from her lab by pandemic restrictions, behavioral ecologist Daniela C. Robler caught local jumping spiders and kept them in clear plastic boxes on her windowsill, planning to test their reactions to 3-D-printed models of predatory spiders. When she came home from dinner one night, though, she noticed something strange. "They were all hanging from the lids of their boxes," says Robler, a postdoctoral researcher at the University of Konstanz in Germany. She had never seen jumping spiders suspended motionless on silk lines like this before. "I had no idea what happened," Robler says. "I thought they were dead." It turns out the jumping spiders were simply asleep -- and that Robler had discovered an alternate sleeping habit of the species Evarcha arcuata, which had been known to build silk sleeping dens in curled-up dead leaves. But the real surprise came when she decided to spy on them all night. [...]

Mostly the spider just hung there. But then her legs started to twitch, and her abdomen and even her silk-producing spinnerets did so as well. Sometimes her legs curled in toward her sternum. With every spider Robler recorded, these odd movements only appeared during distinct bouts that lasted a little more than a minute and occurred periodically throughout the night. "They were just uncontrollably twitching in a way that really looked a lot like when dogs or cats dream and have their little REM phases," she says. [...] Robler and her colleagues wondered if the twitching spiders could be experiencing something like an REM phase of sleep and possibly even having dreams. "We were like, 'Okay, that would be insane,'" she says. Then she thought, "Let's figure it out," and immediately changed her research plans for the spiders.

[...] When Robler recorded 34 sleeping spiderlings, she found that their twitches were accompanied by unmistakable eye-tube movements that did not happen during other phases of sleep. [...] But it is too soon to say for sure that the spiders are experiencing something akin to REM sleep in humans. The researchers first need to confirm the spiders are actually asleep during this phase by showing that they are less responsive to their environment. Robler and her "dream team" of co-authors have already started those tests. And she points out that the leg curling is a particularly striking aspect of the spiders' REM-like phase because that pose is typically only seen in dead spiders. Spiders use hydraulic pressure maintained by muscles to keep their legs extended, and the curling could result from the muscle paralysis that typifies REM sleep. The team's initial findings were published in Proceedings of the National Academy of Sciences USA.

An anonymous reader quotes a report from The New York Times: African clawed frogs are masters of putting themselves back together, handily regenerating lost tails and hind limbs, when they are tadpoles. But these powers dim with maturity. Wait for an adult frog to regrow a lopped-off limb and you'll see only a tapered spike, more like a talon than a leg. Now, a group of scientists have found a way to harness the adult frog's own cells to regrow an imperfect but functional limb. The researchers placed a silicone cap laden with a mixture of regenerative drugs onto an amputation wound for 24 hours. Over the next 18 months, the frogs gradually regrew what was lost, forming a new leglike structure with nerves, muscles, bones and even toelike projections.

The researchers describe this approach, which builds on earlier research, in a paper published Wednesday in the journal Science Advances. The process could guide future research on limb regeneration in humans, but it will be challenging to replicate the results in mammals. "It was a total surprise," Nirosha Murugan, a researcher at Algoma University in Ontario, Canada, and an author of the paper, said of the complexity of the regrown limb. "I didn't think we would get the patterning that we did." "It's not a full limb that's regrown," said Kelly Tseng, a biologist studying regeneration at the University of Nevada, Las Vegas, who was not involved with the research. "But it's certainly a robust response." "It is particularly promising that only a daylong treatment can have such a positive effect on an adult animal," Can Aztekin, a researcher studying limb regeneration at the Swiss Federal Institute of Technology in Lausanne who was not involved with the research, wrote in an email.

The Cabinet Office of Japan is co-hosting an event dedicated to "Society 5.0," a future society the government believes Japan should aspire to. Defined by the Cabinet Office as "a human-centered society [helped] by a system that highly integrates cyberspace and physical space," Society 5.0 is a concept intended to broaden the discussion of innovation from science and technology to all of socioeconomic activity. Nikkei Asia Review reports: The government has also established multiple large-scale programs to encourage companies, involved in everything from health care and mobility to energy, to invest in research and development, not only at the level of pure technology but also to bring it to a pilot level. The exhibition includes some achievements from these programs, including Cyberdyne's HAL, standing for "hybrid assistive limb," which the company claims to be the world's first "wearable cyborg." A HAL exoskeleton autonomously walks on a treadmill at the venue. When worn on a leg, HAL can read faint signals sent to muscles from the brain thanks to electrodes attached to the wearer's skin, determining the wearer's desired movements. "Even if your nerves are not connected at first, they gradually recover through the wearing of HAL, and you can eventually move your own body parts without wearing it," said a person from Cyberdyne.

SkyDrive's "flying car" also attracts the attention of visitors, who can observe a full-scale model of the SD-03, which performed the first successful public manned flights of a flying car in Japan in August 2020. Co-founded by former Toyota Motor engineer Tomohiro Fukuzawa, the startup plans to offer commercial mobility service during Expo 2025, to be held in Osaka. "It is as if we are traveling to the future," said Shinji Inoue, a minister of state who heads science and technology policy, when he visited the exhibition last week. Asked by reporters how to make these cutting-edge tools an everyday reality, Inoue spoke of a need to deregulate the market when it comes to obtaining operating permits for such items. Indeed, the government acknowledges challenges in keeping up with the country's capabilities in implementing scientific progress. Digitalization initiatives, the premise for achieving Society 5.0, "could not sufficiently create new business models through data collaboration, like what we see in other countries," said a report from the Cabinet Office analyzing the previous five-year plan through fiscal 2020. Instead, the initiatives aimed at improving the efficiency of existing operations, failing to drive innovation.

MIT Technology Review recently discussed new attempts to replace the standard 'QWERY' keyboard layout, including Tap, "a one-handed gadget that fits over your fingers like rubbery brass knuckles and connects wirelessly to your smartphone." It's supposed to free you from clunky physical keyboards and act as a go-anywhere typing interface. A promotional video shows smiling people wearing Tap and typing with one hand on a leg, on an arm, and even (perhaps jokingly) on some guy's forehead... But when I tried it, the reality of using Tap was neither fun nor funny. Unlike a conventional QWERTY keyboard, Tap required me to think a lot, because I had to tap my fingers in not-very-intuitive combinations to create letters: an A is your thumb, a B is your index finger and pinky, a C is all your fingers except the index.
The article also acknowledges the Dvorak Simplified Keyboard layout and other alternatives like the one-handed Twiddler keyboard, but argues that "neither managed to dent QWERTY's dominance." [W]hat if the future is no input interface at all? Neurable is a startup in Cambridge, Massachusetts, that's working on a way to type simply by thinking. It uses an electrode-dotted headband connected to a VR headset to track brain activity. Machine learning helps figure out what letter you're trying to select and anticipate which key you'll want next. After you select several keys, it can fill in the rest of the word, says cofounder and CEO Ramses Alcaide....

Then there's the device being built over at CTRL-Labs: an armband that detects the activity of muscle fibers in the arm. One use could be to replace gaming controllers. For another feature in the works, algorithms use the data to figure out what it is that your hands are trying to type, even if they're barely moving. CEO and cofounder Thomas Reardon, who previously created Microsoft's Internet Explorer, says this too is a neural interface, of a sort. Whether you're typing or dictating, you're using your brain to turn muscles on and off, he points out.
While a developer version will be shipped this year, Reardon "admits that it is still not good enough for him to toss his trusty mid-'80s IBM Model M keyboard, which he says still 'sounds like rolling thunder' when he types." But do any Slashdot readers have their own suggestions or experiences to share?

Can anything replace 'QWERTY' keyboards?

An anonymous reader quotes a report from Nature: For more than a decade, neuroscientist Gregoire Courtine has been flying every few months from his lab at the Swiss Federal Institute of Technology in Lausanne to another lab in Beijing, China, where he conducts research on monkeys with the aim of treating spinal-cord injuries. The commute is exhausting -- on occasion he has even flown to Beijing, done experiments, and returned the same night. But it is worth it, says Courtine, because working with monkeys in China is less burdened by regulation than it is in Europe and the United States. And this week, he and his team report the results of experiments in Beijing, in which a wireless brain implant -- that stimulates electrodes in the leg by recreating signals recorded from the brain -- has enabled monkeys with spinal-cord injuries to walk. The treatment is a potential boon for immobile patients: Courtine has already started a trial in Switzerland, using a pared-down version of the technology in two people with spinal-cord injury. The team first mapped how electric signals are sent from the brain to leg muscles in healthy monkeys, walking on a treadmill. They also examined the lower spine, where electric signals from the brain arrive before being transmitted to muscles in the legs. Then they recreated those signals in monkeys with severed spinal cords, focusing on particular key points in the lower part of the spine. Microelectrode arrays implanted in the brain of the paralyzed monkeys picked up and decoded the signals that had earlier been associated with leg movement. Those signals were sent wirelessly to devices that generate electric pulses in the lower spine, which triggered muscles in the monkeys' legs into motion.

HughPickens.com writes: There are good reasons it's been 37 years since the last triple-crown winner. As Lexi Pandell writes, post-race recovery is no joke for a thousand-pound animal that can run more than 40 miles per hour. There are two weeks between the Derby and the Preakness, and three weeks between the Preakness and the Belmont. That tight schedule—and the super-specific needs of racehorses—means horses competing in the grueling back-to-back-to-back Triple Crown races have a big disadvantage against fresh horses. First, as a horse races, its muscles produce lactic acid. In humans, glycogen recoup takes about 24 hours. But horses take several days to process lactic acid and restore glycogen reserves. Trainers make sure their charges drink plenty of water and sometimes even use intravenous fluids to aid that repair process. Secondly, in addition to being the last race of the Triple Crown, the Belmont Stakes is also the longest. When a horse runs a tough race (or has a new workout at a longer distance), its muscles break down. Then, during rest, they reknit and adapt. A horse that has skipped the Preakness, however, has the luxury of time. Mubtaahij, who some picked to win the Belmont, had plenty of rest so he could be pushed for hard workouts two weeks prior to the Belmont.

Finally, at different points in its stride, a galloping horse puts all its weight on a single leg. That limb bears three times more weight than usual when galloping on a straightaway and, thanks to centrifugal force, a load five to 10 times greater on turns. This translates to skeletal microdamage. Race a horse during that critical period and you increase the risk of serious injuries mid-race. Two weeks ago, vets were forced to euthanize the promising gray thoroughbred filly, Eight Belles, when she collapsed on the track after completing the race at Churchill Downs, suffering from two shattered ankles in her front legs. A fresh horse won't face any of those problems. Even a horse that ran in the Derby but skipped the Preakness will have five weeks to rest, and plenty of time for normal skeletal damage to repair, before the Belmont. "So, American Pharoah, it'd be awesome if you win the Triple Crown, but you probably won't," concluded Pandell. "It's not your fault. It's science and those pesky fresh horses." Science was wrong.

An anonymous reader writes: Today, an Icelandic prosthetic-maker announced that two amputees have been testing brain-controlled bionic legs for over a year. The devices respond to impulses in the subjects' residual limbs, via sensors that were implanted in simple, 15-minute-long procedures. "When the electrical impulse from his brain reaches the base of his leg, a pair of sensors embedded in his muscle tissue connect the neural dots, and wirelessly transmit that signal to the Proprio Foot. Since the command reaches the foot before the wearer's residual muscles actually contract, there's no unnatural lag between intention and action." This is a huge step forward (sorry) for this class of bionics. It may seem like a solved problem based on reports and videos from laboratories, but it's never been exposed to real world use and everyday wear and tear like this.

HughPickens.com writes The human genome is astonishingly complex and dynamic, with genes constantly turning on or off, depending on what biochemical signals they receive from the body. Scientists have known that certain genes become active or quieter as a result of exercise but they hadn't understood how those genes knew how to respond to exercise. Now the NYT reports that scientists at the Karolinska Institute in Stockholm have completed a study where they recruited 23 young and healthy men and women, brought them to the lab for a series of physical performance and medical tests, including a muscle biopsy, and then asked them to exercise half of their lower bodies for three months. The volunteers pedaled one-legged at a moderate pace for 45 minutes, four times per week for three months. Then the scientists repeated the muscle biopsies and other tests with each volunteer. Not surprisingly, the volunteers' exercised leg was more powerful now than the other, showing that the exercise had resulted in physical improvements. But there were also changes within the exercised muscle cells' DNA. Using technology that analyses 480,000 positions throughout the genome, they could see that new methylation patterns had taken place in 7,000 genes (an individual has 20–25,000 genes).

In a process known as DNA methylation, clusters of atoms, called methyl groups, attach to the outside of a gene like microscopic mollusks and make the gene more or less able to receive and respond to biochemical signals from the body. In the exercised portions of the bodies, many of the methylation changes were on portions of the genome known as enhancers that can amplify the expression of proteins by genes. And gene expression was noticeably increased or changed in thousands of the muscle-cell genes that the researchers studied. Most of the genes in question are known to play a role in energy metabolism, insulin response and inflammation within muscles. In other words, they affect how healthy and fit our muscles — and bodies — become. Many mysteries still remain but the message of the study is unambiguous. "Through endurance training — a lifestyle change that is easily available for most people and doesn't cost much money," says Sara Lindholm, "we can induce changes that affect how we use our genes and, through that, get healthier and more functional muscles that ultimately improve our quality of life."

An anonymous reader writes: The military and private contractors have been toying with exoskeletal combat suits for a while, but Harvard's Wyss Institute has a new take on the concept. Rather than using a hard metal frame and the massively overpowered mechanical servos necessary to move it, the Soft Exosuit is a lightweight mesh of webbing combined with a series of strain sensors and basic microprocessors. "The suit mimics the action of leg muscles and tendons when a person walks, and provides small but carefully timed assistance at the leg joints without restricting the wearer's movement." The suit continually monitors its wearer's body position, movement, and muscular strain, providing small amounts of targeted support. The team has now received $2.9 million in funding from DARPA to refine the suit's design. They say they'll be working on medical applications for the suit as well as military ones.

GameboyRMH writes "A gear mechanism has been discovered [paywalled original paper here, for those with access] for the first time in nature in the nymph of the Issus, a small plant-hopping insect common in Europe. It uses the gears to synchronize the movement and power of its hind legs, forcing the legs to propel it in a straight line when jumping, which would otherwise be impossible for the insect if it had to control the timing and force of its leg muscles independently."

Marine Isaias Hernandez has been able to grow back most of the missing muscle from his leg, including skeletal muscle, thanks to an experimental treatment involving an injection of a a growth promoting substance extracted from pig bladders. Hernandez lost 70% of his right thigh muscles from a mortar exploded attack in Afghanistan. Normally this type of injury would lead to an amputation. From the article: "In preparation for the operation, corporal Hernandez was made to build up the remaining 30 per cent of muscle left on the damaged thigh. Surgeons then sliced into the thigh, placing a thin slice of a substance called extracellular matrix. The surgery is the result of a $70 million investment by the US military into regenerative medicine research."

fangmcgee writes "A 'bionic' leg designed for people who have lost a lower leg is undergoing clinical trials sponsored by the US Army. The researchers hope the leg will be able to learn the patient's nerve signal patterns and be able to move in response to the patient's own muscles and nerves (abstract). Electrodes are attached to nine muscles in the thigh to detect the patterns in which the nerve signals are fired. Different patterns correspond to different intended movements. In the current stages of training, the volunteers are wired up to the electrodes and learn how to use the muscles to make a computer avatar move on screen. Results showed that all the volunteers could control the avatar’s knee and ankle movements from neural information from the thigh, with amputees achieving 91 percent accuracy of movement and the non-amputees achieving 89 percent."

Khemisty writes "Back in grade school you were probably taught the importance of warm-up exercises, and it's likely you've continued with pretty much the same routine ever since. Science, however, has moved on. Researchers now believe that some of the more entrenched elements of many athletes' warm-up regimens are not only a waste of time but are actually bad for you. The old presumption that holding a stretch for 20 to 30 seconds — known as static stretching — primes muscles for a workout is dead wrong. It actually weakens them. In a recent study conducted at the University of Nevada, athletes generated less force from their leg muscles after static stretching than they did after not stretching at all. Other studies have found that this stretching decreases muscle strength by as much as 30 percent. Also, stretching one leg's muscles can reduce strength in the other leg as well, probably because the central nervous system rebels against the movements."

Ant writes "Link: New models of the leg muscles of Tyrannosaurus Rex suggest that a real T-Rex might not have passed the screen test for "Jurassic Park." Stanford University researchers writing in the British journal Nature this week suggest that a T-Rex could not have been able to run as fast as the one in the movie -- and might not have been able to run at all. "There is no way you could fit enough muscle into its body for that kind of locomotion," said John Hutchinson, co-author of the Nature article. "You wouldn't have enough room left over for all the other body parts.""

This is the seventh in our continuing reprint of Jon Katz' series beginning with his column "Voices From the Hellmouth," which serves to illustrate how deeply problems can lurk even under apparent normality.

Below is part seven in our continuing reprint of John Katz's columns about the events in Littleton, Colorado, and the reaction that the columns and that tragedy generated.