The Wall Street Journal visits scientists at Harvard University's Wyss Institute for Biologically Inspired Engineering who are researching a "sugar-to-fiber" enzyme (normally used by plants to create stalks). They're testing a version they've "encased in spherical nanoparticles — tiny mesh-like cages made of pectin that allow the enzyme to be added to food without being activated until it reaches the intestine.

"Once there, a change in pH causes the cage to expand, freeing the enzyme to float through its holes and start converting sugar to fiber." The Wyss Institute's goal for its enzyme product was to reduce the sugar absorbed from food by 30%, though it has the potential to remove even more than that, says Sam Inverso, director of business development partnerships at the Wyss Institute. The enzyme's ability to turn sugar into fiber is also key, as most Americans don't get nearly enough fiber in their diet, says Adama Sesay, a senior engineer at the Wyss Institute who worked on the project...

The Wyss Institute is now licensing the technology to a company to help bring its enzyme product to market, a process that entails additional testing and work to secure regulatory approval. Inverso says that the aim is for the product to be available to U.S. food manufacturers within the next two years, and that other encapsulated enzymes could follow: products that reduce lactose absorption after drinking milk, or cut gluten after eating bread. For now the enzyme works better in solid food than in a liquid. Producing it in large quantities and at low cost is still a ways off — currently it's 100 times more expensive than raw sugar, Inverso says.
And the Journal notes they're not the only ones working on the problem: San Francisco-based startup Biolumen recently launched a product called Monch Monch, a drink mix made of fibrous, microscopic sponges designed to soak up sugar and prevent it from reaching the bloodstream. At mealtime consumers can blend a teaspoon of Monch Monch, which has no taste, smell or color, into drinks from water to wine. Once it has reached the stomach, the sponges start to swell and sequester sugar, reducing its burden on the body, says Dr. Robert Lustig, Biolumen's co-founder and chief medical officer... One gram of Monch Monch can sequester six grams of sugar, says Lustig... The product, introduced as a dietary supplement, can also be used as a food ingredient under a Food and Drug Administration principle known as "generally recognized as safe." Packets of Monch Monch are available for purchase online, and Biolumen says it is in talks with U.S. food manufacturers it declined to name about its use in other products...

Food companies are betting on other solutions for now. Cereal startup Magic Spoon uses allulose, a natural sugar found in figs and raisins that is growing in popularity, helped by FDA guidance that allows it to be excluded from sugar or added-sugar totals on nutrition labels. Ingredient company Tate & Lyle, which makes allulose from corn kernels, says the sweetener tastes like sugar and adds bulk and caramel color, but passes through the body without being metabolized... Chicago-based Blommer Chocolate recently launched a line of reduced-sugar chocolate and confectionery products made with Incredo, a sugar that has been physically altered to taste sweeter using a mineral carrier that dissolves faster in saliva and targets the sweet-taste receptors on the tongue. Incredo's use enables manufacturers to use up to 50% less sugar, the company says.
The article even notes that "researchers still working to reduce sugar are peddling new technologies, like individual sugar crystals modified to dissolve more quickly in the mouth, making food taste sweeter."

When Disneyland opened in 1955, its car-themed attraction Autopia "represented the future of what would become America's multilane limited-access highways," according to Wikipedia, " which were still being developed. President Eisenhower had yet to sign the Interstate Highway legislation..."

Wikipedia adds that the cars "generate a moderate level of exhaust from the Honda GX gasoline engines that propel the cars." But that may change, according to a climate-oriented newsletter from the Los Angeles Times: If anyone could get away with defending the toxic odor, it might be Bob Gurr. He designed the original Autopia cars in the mid-1950s, working closely with Walt himself. He's proud of what they built together. But today the 92-year-old Disney legend says the polluting motors need to go. "Get rid of those God-awful gasoline fumes," he told me.

Disney is finally preparing to do just that. In news shared exclusively with The Times ahead of this column's publication — after several weeks of my prodding the company for answers on the future of Autopia — Disney officials revealed that pure gasoline engines are on their way out... "As the industry moves toward alternative fuel sources, we have developed a roadmap to electrify this attraction and are evaluating technology that will enable us to convert from gas engines in the next few years," spokesperson Jessica Good said in an email. Good wouldn't confirm whether that means electric vehicles, or if hybrids are a possibility...

[Gurr] also expressed a grander vision for Tomorrowland as a hub for stories about renewable energy, public transit and other sustainable technologies that will help us create a better tomorrow... [H]ow about using the former Innoventions building, which once displayed futuristic technologies but is now closed to most guests, to showcase solar panels, lithium-ion batteries and other clean energy devices that guests might want in their homes...? Why not switch to electric cooking at the Alien Pizza Planet restaurant, and offer induction stove demos for diners? Maybe start screening some National Geographic films (Disney owns NatGeo) at the largely unused Magic Eye Theater...? Add some infotainment-style signs and voice-overs about the wonders of clean energy and public transit, and boom, you've got a Tomorrowland that should leave kids and their parents excited to help build a safer, happier, more sustainable world...

[Gurr] told me that if he could, he'd tear out everything in Tomorrowland except the Monorail and rebuild it as a version of the public transit-oriented futuristic city that Walt once planned for Florida — only with clean energy at the core of its storytelling... At the very least, he said it's time for an Autopia where guests "don't smell the fumes, don't hear that racket of the little motor going putt-putt-putt."
The newsletter agrees electric vehicles for Autopia are "the obvious starting point" for remodeling Tomorrowland with "a buzz of optimism and futuristic energy." ("Solar-panel shade structures over the line would be great too.") They even add that "it's not that it's my job to make money for Disney, but I'm sure the company could find sponsors for this vision of Tomorrowland. There are plenty of renewable energy companies, electric utilities and environmental groups eager to tout their causes and their credentials."

And it shares this observation from climate scientist and communicator Katharine Hayhoe (paraphrasing another scientist who studies climate communications): "Showing people what climate solutions look like is one of the most effective ways to get them to support action." The newsletter's conclusion? "This is where Tomorrowland could prove especially valuable in the fight to save the planet."


Some additional context... Disney's current CEO once said he was "particuarly proud" of the 270-acre, 50+-megawatt solar facility the company brought online in Orlando." And the Washington Post reports that Disney's plans to electrify Autopia "comes as the park is taking steps to decarbonize as part of an effort to reach a goal of net-zero emissions by 2030."

Cambridge dictionary's word of the year for 2023 is "hallucinate," a verb that took on a new meaning with the rise in popularity of artificial intelligence chatbots. The Guardian reports: The original definition of the chosen word is to "seem to see, hear, feel, or smell" something that does not exist, usually because of "a health condition or because you have taken a drug." It now has an additional meaning, relating to when artificial intelligence systems such as ChatGPT, which generates text that mimics human writing, "hallucinates" and produces false information. The word was chosen because the new meaning "gets to the heart of why people are talking about AI," according to a post on the dictionary site.

Generative AI is a "powerful" but "far from perfect" tool, "one we're all still learning how to interact with safely and effectively -- this means being aware of both its potential strengths and its current weaknesses." The dictionary added a number of AI-related entries this year, including large language model (or LLM), generative AI (or GenAI), and GPT (an abbreviation of Generative Pre-trained Transformer). "AI hallucinations remind us that humans still need to bring their critical thinking skills to the use of these tools," continued the post. "Large language models are only as reliable as the information their algorithms learn from. Human expertise is arguably more important than ever, to create the authoritative and up-to-date information that LLMs can be trained on."

Climate breakdown is already changing the taste and quality of beer, scientists have warned. From a report: The quantity and quality of hops, a key ingredient in most beers, is being affected by global heating, according to a study. As a result, beer may become more expensive and manufacturers will have to adapt their brewing methods. Researchers forecast that hop yields in European growing regions will fall by 4-18% by 2050 if farmers do not adapt to hotter and drier weather, while the content of alpha acids in the hops, which gives beers their distinctive taste and smell, will fall by 20-31%.

"Beer drinkers will definitely see the climate change, either in the price tag or the quality," said Miroslav Trnka, a scientist at the Global Change Research Institute of the Czech Academy of Sciences and co-author of the study, published in the journal Nature Communications. "That seems to be inevitable from our data." Beer, the third-most popular drink in the world after water and tea, is made by fermenting malted grains like barley with yeast. It is usually flavoured with aromatic hops grown mostly in the middle latitudes that are sensitive to changes in light, heat and water. Climate-induced decline in the quality and quantity of European hops calls for immediate adaptation measures (Nature).

The energy industry is turning waste from dairy farms into renewable natural gas -- but will it actually reduce emissions? From a report: On an early August afternoon at Pinnacle Dairy, a farm located near the middle of California's long Central Valley, 1,300 Jersey cows idle in the shade of open-air barns. Above them whir fans the size of satellites, circulating a breeze as the temperature pushes 100F (38C). Underfoot, a wet layer of feces emits a thick stench that hangs in the air. Just a tad unpleasant, the smell represents a potential goldmine. The energy industry is transforming mounds of manure into a lucrative "carbon negative fuel" capable of powering everything from municipal buses to cargo trucks. To do so, it's turning to dairy farms, which offer a reliable, long-term supply of the material. Pinnacle is just one of hundreds across the state that have recently sold the rights to their manure to energy producers.

Communities around the world have long generated electricity from waste, but the past few years have seen a surge in public and private investment into poop-to-energy infrastructure in the US. Though so far concentrated in states with dominant dairy sectors, like California, Wisconsin and New York, Biden's landmark climate law passed last summer stands to unleash additional billions to support further development nationwide. The sector's boosters describe it as an elegant way to cut emissions from both livestock and transport; but critics worry that the nascent industry could raise more issues than it resolves by entrenching environmentally harmful practices.

Animal agriculture is the nation's single biggest source of methane, a greenhouse gas that climate scientists call a "super pollutant" due to its high short-term warming potential. The gas is released from animals when they burp, and through the decomposition of manure when collected in open-air ponds, a common livestock industry practice. But those emissions are also a potential moneymaker. Methane from animal waste can be purified into a product virtually indistinguishable from fossil fuel-based natural gas. Marketed as renewable natural gas (RNG), it has a unique profit-making edge: in addition to revenue from the sale of the gas itself, energy companies can now also earn handsome environmental subsidies for their role in keeping methane out of the atmosphere.

A new study finds that some people really are "mosquito magnets" and it probably has to do with the way they smell. From a report: The researchers found that people who are most attractive to mosquitoes produce a lot of certain chemicals on their skin that are tied to smell. And bad news for mosquito magnets: they stay loyal to their favorites over time. "If you have high levels of this stuff on your skin, you're going to be the one at the picnic getting all the bites," said study author Leslie Vosshall, a neurobiologist at Rockefeller University in New York. There is folklore about who gets bitten more, but many claims are not backed up with strong evidence, said Vosshall.

The researchers designed an experiment pitting people's scents against each other, explained study author Maria Elena De Obaldia. Their findings were published Tuesday in the journal Cell. They asked 64 volunteers from the university and nearby to wear nylon stockings around their forearms to pick up their skin smells. The stockings were put in separate traps at the end of a long tube, then dozens of mosquitos were released. "They would basically swarm to the most attractive subjects," De Obaldia said. "It became very obvious right away." Scientists held a round-robin tournament and ended up with a striking gap: the biggest mosquito magnet was around 100 times more attractive to the mosquitoes than the last place finisher.

Diana Kwon writes via Scientific American: A Scottish woman named Joy Milne made headlines in 2015 for an unusual talent: her ability to sniff out people afflicted with Parkinson's disease, a progressive neurodegenerative illness that is estimated to affect nearly a million people in the U.S. alone. Since then a group of scientists in the U.K. has been working with Milne to pinpoint the molecules that give Parkinson's its distinct olfactory signature. The team has now zeroed in on a set of molecules specific to the disease -- and has created a simple skin-swab-based test to detect them.

[...] The researchers used mass spectrometry to identify types and quantities of molecules in a sample of sebum, an oily substance found on the skin's surface. They discovered changes to fatty molecules known as lipids in people with Parkinson's. In their latest study, published on September 7 in the American Chemical Society journal JACS Au, the researchers revealed the results of using a simple skin-swab-based test to detect the lipid signature that is indicative of Parkinson's. By comparing sebum samples from 79 people with Parkinson's and 71 people without the illness, the team zeroed in on a set of large lipids that could be detected in a matter of minutes using a special type of mass spectrometry in which substances are rapidly transferred from a swab to an analyzer using just a piece of paper.

"I think it's a very promising set of biomarkers," says Blaine Roberts, a biochemist at Emory University, who wasn't involved in the work. He adds that one of the big open questions that remains is how exacting this test can be. While the authors of the September 7 study reported the detailed chemical profile of the unique Parkinson's signature, they did not include an assessment of its accuracy. According to Barran, based on not-yet-published data, their test appears to be able to determine whether an individual has Parkinson's with more than 90 percent accuracy. [...] The team is now working with local hospitals to determine whether this sebum-based test can also be conducted in clinical labs -- a key step toward determining whether it can be used as a diagnostic tool. Ultimately, Barran says, the hope is to use the test to help identify individuals who have been referred to their neurologists by their general practitioner for suspected Parkinson's so they can receive a faster diagnosis. The researchers are also working with a group at Harvard "to determine whether sebum-based biomarkers are detectable in people who have constipation, a reduced sense of smell or other early signs of Parkinson's but have not yet received a diagnosis," reports Kwon.

Meanwhile, Milne is working with scientists to sniff out people with Alzheimer's, cancer, and tuberculosis -- all of which she says have a unique smell.

During at least the first few months following a coronavirus infection, even mild cases of Covid-19 are associated with subtle tissue damage and accelerated losses in brain regions tied to the sense of smell, as well as a small loss in the brain's overall volume, a new British study finds. Having mild Covid is also associated with a cognitive function deficit. NBC: These are the striking findings of the new study led by University of Oxford investigators, one that leading Covid researchers consider particularly important because it is the first study of the disease's potential impact on the brain that is based on brain scans taken both before and after participants contracted the coronavirus. "This study design overcomes some of the major limitations of most brain-related studies of Covid-19 to date, which rely on analysis and interpretation at a single time point in people who had Covid-19," said Dr. Serena S. Spudich, a neurologist at the Yale University School of Medicine, who was not involved in the research.

The research, which was published Monday in Nature, also stands out because the lion's share of its participants apparently had mild Covid -- by far, the most common outcome of coronavirus infections. Most of the brain-related studies in this field have focused on those with moderate to severe Covid. Gwenaelle Douaud, an associate professor at the Nuffield Department of Clinical Neurosciences at Oxford and the paper's lead author, said that the excess loss of brain volume she and her colleagues observed in brain scans of hundreds of British individuals is equivalent to at least one extra year of normal aging. "It is brain damage, but it is possible that it is reversible," she said. "But it is still relatively scary because it was in mildly infected people."

An anonymous reader quotes a report from The New York Times: When you take a whiff of something, odor molecules sail inside your nose where they bind to proteins -- called olfactory receptors -- on cells that line your nasal cavity. These receptors trigger signals that your brain interprets as one or many smells. A team of scientists has identified the olfactory receptors for two common odor molecules: a musk found in soaps and perfumes and a compound prominent in smelly underarm sweat. The research team also discovered that more recent evolutionary changes to these olfactory receptors make people less sensitive to those odors. So if you're one of the fortunate ones who isn't overwhelmed by body odor, you should probably thank evolution. The work was published in PLoS Genetics on Thursday.

Olfactory receptors can be traced back hundreds of millions of years and are believed to be present in all vertebrates. Humans have around 800 olfactory receptor genes, but only about half of them are functional, meaning they'll be translated into proteins that hang out in the nose and detect odor molecules. But within a functional gene, minor variations can cause changes in its corresponding receptor protein, and those changes can massively affect how an odor is perceived. [...] Trans-3-methyl-2-hexenoic acid is considered one of the most pungent compounds in underarm sweat. Galaxolide is a synthetic musk often described as having a floral, woody odor that's used in perfumes and cosmetics, but also things like kitty litter. The research team was able to identify olfactory receptor variants for those odors and, in both cases, people with the more evolutionarily recent gene variant found the odors significantly less intense. The galaxolide findings were particularly striking, with some participants unable to smell the musk at all. "It's really rare to find an effect that's as large as what we saw for this one receptor on the perception of the musk odor," said Marissa Kamarck, a neuroscientist at the University of Pennsylvania who was an author of the study.

[Hiroaki Matsunami, a molecular biologist at Duke University who was not involved in the research] views this work as another example of human olfaction being more complex than people initially thought. He said that, although the major findings in the study involved just two scents, they're adding to evidence that "odorant receptors as a group have extraordinary variety." The authors think their findings support a hypothesis that has been criticized that the primate olfactory system has degenerated over evolutionary time. Kara Hoover, an anthropologist at the University of Alaska Fairbanks who was not involved in this research but who studies the evolution of human smell, is not convinced by that hypothesis in the first place. "Why is reduced intensity assumed to be degradation?" she asked. "Maybe other things are becoming more intense or odor discrimination is improving. We know too little to make these conclusions." For Dr. Hoover, these findings stirred up other evolutionary questions. "Our species is really young," she said. "Why this much variation in such a short period of time? Is there an adaptive significance?"

Yankee Candle reviews on Amazon may be the latest indicator of COVID's surge nationwide. Ichijo shares a report: Some customers who recently purchased from the scented-candle brand using Amazon are flooding the site with negative reviews that say the candles have a barely noticeable scent or no scent at all. While many reviewers gave the candles five stars and described a strong scent reminiscent of Christmas trees, others said they couldn't smell anything or could only smell burning wax. "I've bought this candle before, and the fragrance would fill the room. This one barely has a scent. Boo," said one December 20 review for Yankee Candle's balsam and cedar scent. "No scent whatsoever unless you face-plant into the glass vessel. Burned it for eight hours and, ta-da, NO fragrance," another reviewer wrote on December 19. But the candles may not be the problem. Those customers may have lost their sense of smell, a symptom of COVID-19. Loss of smell, known as anosmia, has become one of the defining symptoms of COVID. While some people regain the ability to smell upon recovering from COVID, others report being unable to smell for months, or even a year, after having COVID. Nick Beauchamp, an assistant professor of political science at Northeastern University, charted the complaints for the top three Yankee Candles on Amazon. He tracked when the negative reviews began and how much those complaints increased per week. His graph showed a sharp spike around December, just as the Omicron variant led to a new wave of COVID cases in the US.

"The thought of combining a printer (the bane of office workers) with the bacterium E. coli (the scourge of romaine lettuce) may seem an odd, if not unpleasant, collaboration," writes the New York Times.

"But scientists have recently melded the virtues of the infuriating tool and of the toxic microbe to produce an ink that is alive, made entirely from microbes." The microbial ink flows like toothpaste under pressure and can be 3D-printed into various tiny shapes — a circle, a square and a cone — all of which hold their form and glisten like Jell-O. The researchers describe their recipe for their programmable, microbial ink in a study published on Tuesday in the journal Nature Communications.

The material is still being developed, but the authors suggest that the ink could be a crucial renewable building material, able to grow and heal itself and ideal for constructing sustainable homes on Earth and in space... [T]he new substance contains no additional polymers; it is produced entirely from genetically engineered E. coli bacteria. The researchers induce bacterial cultures to grow the ink, which is also made of living bacteria cells. When the ink is harvested from the liquid culture, it becomes firm like gelatin and can be plugged into 3D-printers and printed into living structures, which do not grow further and remain in their printed forms...

Bacteria may seem an unconventional building block. But microbes are a crucial component of products such as perfumes and vitamins, and scientists have already engineered microbes to produce biodegradable plastics. A material like a microbial ink has more grandiose ambitions, according to Neel Joshi, a synthetic biologist at Northeastern University and an author on the new paper. Such inks are an expanding focus of the field of engineered living materials. Unlike structures cast from concrete or plastic, living systems would be autonomous, adaptive to environmental cues and able to regenerate — at least, that is the aspirational goal, Dr. Joshi said. "Imagine creating buildings that heal themselves," said Sujit Datta, a chemical and biological engineer at Princeton University who was not involved with the research....

Dr. Manjula-Basavanna is shooting for the moon, Earth's satellite, where there are no forests to harvest for wood and no easy way to send bulk building materials. There, he said, the ink might be used as a self-regenerating substance to help build habitats on other planets, as well as places on Earth. "There is a lot of work to be done to make it scalable and economic," Dr. Datta conceded. But, he noted, just five years ago creating robust structures out of microbes was unimaginable; conceivably, self-healing buildings could be a reality in our lifetime.

An anonymous reader quotes a report from The Guardian: The virus that causes Covid-19 does not infect human brain cells, according to a study published in the journal Cell. The findings will raise hopes that the damage caused by Sars-CoV-2 might be more superficial and reversible than previously feared. The study contradicts earlier research that suggested the virus infects neurons in the membrane that lines the upper recesses of the nose. This membrane, called the olfactory mucosa, is where the virus first lands when it is inhaled. Within it are olfactory sensory neurons (OSNs), which are responsible for initiating smell sensations. They are tightly entwined with a kind of support cell called sustentacular cells.

In the new study, Belgian and German researchers claim that the virus infects sustentacular cells but not OSNs. "That is just a critical distinction," said the senior author Peter Mombaerts, who directs the Max Planck Research Unit for Neurogenetics in Frankfurt, Germany. "Once you believe that olfactory neurons can be infected, there is a quick route into the olfactory bulb and then you're in the brain already." The olfactory bulb, at the front of the brain, is where neural input about odors is first processed. If the virus penetrated this structure it could theoretically spread to deeper brain regions where it could do lasting damage -- especially since, unlike OSNs, most neurons are not regenerated once lost. But if the virus only infects the sustentacular cells, then the damage could be less long-lasting. Both pathways could explain the olfactory dysfunction that afflicts an estimated half of all Covid-19 patients. In one in 10 of those, the loss or change of smell is long-term, perhaps permanent. Mombaerts says this could be the result of support for the OSNs breaking down, even if they themselves are not infected. They may function below par, or stop functioning altogether, until the sustentacular cells regenerate.

Scientists at Northwestern University found that people became less sensitive to food odors based on the meal they had eaten just before. These findings show that just as smell regulates what we eat, what we eat -- in turn -- regulates our sense of smell. Phys.Org reports: The study found that participants who had just eaten a meal of either cinnamon buns or pizza were less likely to perceive "meal-matched" odors, but not non-matched odors. The findings were then corroborated with brain scans that showed brain activity in parts of the brain that process odors was altered in a similar way.

Feedback between food intake and the olfactory system may have an evolutionary benefit, said senior and corresponding study author Thorsten Kahnt, an assistant professor of neurology and psychiatry and behavioral sciences at Northwestern University Feinberg School of Medicine. "If you think about our ancestors roaming the forest trying to find food, they find and eat berries and then aren't as sensitive to the smell of berries anymore," Kahnt said. "But maybe they're still sensitive to the smell of mushrooms, so it could theoretically help facilitate diversity in food and nutrient intake."

Kahnt said while we don't see the hunter-gatherer adaptation come out in day-to-day decision-making, the connection between our nose, what we seek out and what we can detect with our nose may still be very important. If the nose isn't working right, for example, the feedback loop may be disrupted, leading to problems with disordered eating and obesity. There may even be links to disrupted sleep, another tie to the olfactory system the Kahnt lab is researching. Kahnt said with a better understanding of the feedback loop between smell and food intake, he's hoping to take the project full circle back to sleep deprivation to see if lack of sleep may impair the loop in some way. He added that with brain imaging, there are more questions about how the adaptation may impact sensory and decision-making circuits in the brain. The study has been published in the journal PLOS Biology.

Bloomberg identifies a variety of cryptocurrency scams, including a "rug pull," where the creators of a new cryptocurrency suddenly cut and run.

"Old-fashioned Ponzi schemes, newly cryptodenominated, have swindled people out of billions too," Bloomberg adds. And a 35-year-old crypto trader living with his parents ("trading meme coins as a full-time job") also tells them about "honey pots," where a coin's creators see a spike in value — and then temporarily disable selling for other holders: It might sound like a joke, given the crypto meltdowns of late, but serious money is at stake here. Billions — real billions — are getting pilfered annually through a variety of cryptocurrency scams. The way things are going, this will only get worse. Back in the Wall Street Dark Ages — six, 12, 18 months ago — these sorts of shenanigans were mostly associated with shlocky brokerages like the one depicted in the 2013 movie The Wolf of Wall Street. In those halcyon days before GameStop, Dogecoin and the rest, schlubs on Long Island might pitch ridiculous over-the-counter stocks to the gullible...

Tokensniffer, aptly named for Shit Coins, claims to have tracked 42,071 tokens and 2,250 scams or hacks. That was as of June 16. More than 200 supposed stings were logged by users during the first two weeks of June alone... His website scrapes data about new meme tokens from popular social media channels and scans the source code... A "smell test" program searches for vulnerabilities. Clones of existing meme tokens are often a red flag. Most recent scams — the site flagged 450 in in one recent 30-day period — were honeypots. Those tend to be easier to spot because of their code, Tokensniffer's creator says. Rug pulls are more complicated.

Such supposed safeguards aside, people are getting scammed in growing numbers. So far this year, over $2.6 billion has been grabbed, according to Chainalysis, a New York-based blockchain researcher. That figure doesn't include a giant Ponzi scheme that just came to light in South Africa. Local authorities put the haul at $3.6 billion worth of Bitcoin. Gob-smacking as all of this might sound, these numbers in fact represent a marked decline from 2019, when fraudsters walked away with an estimated $9 billion. But here's a key difference: the sheer number of people getting hoodwinked. With a few outsize exceptions, most crypto scams seem to be getting smaller. That's the good news. The bad news is that there are more of them, and more people are getting stung. From 2019 to 2020, the number of victims has jumped 48% to an estimated 7.3 million, a figure approaching the official population of Hong Kong. Between the last three months of 2020 and the first three months of 2021, the number of unique scams rose nearly 18%, to 1,335, according to Chainalysis...

Michael Burry, of "The Big Short"-fame, has been warning all of this could all go horribly wrong. An estimated 10,000 new coins have been minted this year. Who can say how many will turn out to be shams? So many Shit Coins are flying around out there, and prices can be so volatile, that many people can't even tell if they've been scammed... This much is sure: no one complains when they're making money. It's when people start losing money — and lately, many have been — that they scream they've been taken.
"A decade after Bitcoin was created, regulators are still grappling with how to police cryptocurrencies," Bloomberg adds, "when the whole point is that they operate without governments or central banks."

The U.S. government spent more than $18 billion last year funding drugmakers to make a Covid vaccine, an effort that led to at least five highly effective shots in record time. Now it's pouring more than $3 billion on a neglected area of research: developing pills to fight the virus early in the course of infection, potentially saving many lives in the years to come. From a report: The new program, announced on Thursday by the Department of Health and Human Services, will speed up the clinical trials of a few promising drug candidates. If all goes well, some of those first pills could be ready by the end of the year. The Antiviral Program for Pandemics will also support research on entirely new drugs -- not just for the coronavirus, but for viruses that could cause future pandemics. A number of other viruses, including influenza, H.I.V. and hepatitis C, can be treated with a simple pill. But despite more than a year of research, no such pill exists to treat someone with a coronavirus infection before it wreaks havoc. Operation Warp Speed, the Trump administration's program for accelerating Covid-19 research, invested far more money in the development of vaccines than of treatments, a gap that the new program will try to fill.

Dr. Anthony Fauci, the director of the National Institute of Allergy and Infectious Diseases and a key backer of the program, said he looked forward to a time when Covid-19 patients could pick up antiviral pills from a pharmacy as soon as they tested positive for the coronavirus or develop Covid-19 symptoms. "I wake up in the morning, I don't feel very well, my sense of smell and taste go away, I get a sore throat," Dr. Fauci said in an interview. "I call up my doctor and I say, 'I have Covid and I need a prescription.'" Dr. Fauci's support for research on antiviral pills stems from his own experience fighting AIDS three decades ago. In the 1990s, his institute conducted research that led to some of the first antiviral pills for H.I.V., "protease inhibitors" that block an essential virus protein and can keep the virus at bay for a lifetime.

If someone created a flying machine capable of tracking you down by listening for your voice, you might be creeped out. But what if you were pinned under a pile of rubble after a natural disaster and first responders couldn't locate you? Maybe then a human-seeking drone wouldn't be such a terrible idea. From a report: That concept is the focus for engineers at Germany's Fraunhofer FKIE institute, who've built a drone prototype designed to find people by detecting human screams and listening for other signs of distress. One of the lead engineers, Macarena Varela, showcased their progress last week at an annual conference hosted by the Acoustic Society of America. While it's easy to imagine human-seeking drones in a sci-fi horror movie, Varela says the gadget would be ideal for post-disaster scenarios, such as earthquakes, hurricanes and wildfires. They could hover over an area that rescue crews have difficulty getting to and pinpoint where people may be trapped.

"[Drones] can cover a larger area in a shorter period of time than rescuers or trained dogs on the ground," Varela said. "If there's a collapsed building, it can alert and assist rescuers. It can go places they can't fly to or get to themselves." Unmanned aerial vehicles or drones are commonly used for search-and-rescue missions when disasters strike. Most often, they take aerial images of structural damage. Some have thermal imaging capabilities to scan for body heat, while larger drones can deliver medical supplies and other goods to people in isolated areas. But researchers are finding more novel uses for an extra set of eyes in the sky -- and noses. The University of Washington imagines drones that use smell to locate disaster survivors. The Aerospace Corporation is working on drones that can visually identify dogs and share their location with rescue teams. The University of Zurich developed a drone to change shape midflight to fit into oddly shaped crevices. Locating people using aerial acoustics presents its share of challenges. An auditory system would need to decipher between human cries and sounds that often happen in nature, such as animal calls and wind. It might also need to recognize patterns associated with kicking, clapping or other ways people try to get the attention of rescue teams.

A heroic rat named Magawa is retiring from sniffing out dozens of land mines in Cambodia for the last five years. NPR reports: Magawa is a Tanzanian-born African giant pouched rat who was trained by APOPO to sniff out explosives. With careful training, he and his rat colleagues learn to identify land mines and alert their human handlers, so the mines can be safely removed. Even among his skilled cohorts working in Cambodia, Magawa is a standout sniffer: In four years he has helped to clear more than 2.4 million square feet of land. In the process, he has found 71 land mines and 38 items of unexploded ordnance. Last year, Magawa received one of Britain's highest animal honors.

Magawa is part of a cohort of rats bred by APOPO for this purpose. He was born in Tanzania in 2014, socialized and moved to Siem Reap, Cambodia, in 2016 to begin his bomb-sniffing career. APOPO uses positive reinforcement methods that give the rats food rewards for accomplishing tasks such as finding a target or walking across a surface. Then they're trained in scent discrimination: choosing explosive smells over something else to get a food reward. Though they have terrible eyesight, the rats are ideal for such work, with their extraordinary sense of smell and their size -- they are too light to trigger the mines. When they detect a mine, they lightly scratch atop it, signaling to their handler what they've found. Their reward: a banana. [T]he rats hone their skills in a training field and are only cleared to begin work once they have perfect accuracy over an 8,600-square-foot area with various stages of complexity.

The days of experts gathering in a sealed-off room to sip coffee and grade beans on their color, aroma and taste may be numbered. From a report: An Israeli company has developed a handheld device that is able to scan beans to determine their quality. The machine, powered by artificial intelligence, will need a human to input the quality parameters first, but after that, it will be able to classify coffee before it's even roasted. The company has completed a pilot program with Carcafe, the Colombian division of Volcafe, one of the world's largest coffee traders. A shift to computers would upend the traditional way coffee has been graded by humans, known as cupping. The well-paid and trained examiners, or Q graders, at the ICE Futures U.S. exchange in New York conduct the laborious task of determining the quality and value of the coffee beans received by the bourse. Trading houses and roasters also usually have their own graders.

Cupping is an involved process, not unlike that undertaken by wine sommeliers. Q graders weigh the coffee and grind it into a cup. They sniff the dry grounds, taking notes on the fragrance. Water heated to 200 degrees Fahrenheit (93 Celsius) is poured over the grounds and the graders smell the wet coffee. After 4 minutes, the crust that forms on top of the cup is broken and grounds and foam are removed. After waiting 15 minutes for the coffee to cool, and only then is the coffee slurped up in a spoon. "It's the human that establishes the sensorial part," said Oswaldo Aranha Neto, a coffee industry veteran who just joined Demetria as a board member. "You need to teach the robot what to do."

An anonymous reader shares an investigative report by LA Times: The plane had begun its descent into Boston. Inside the cockpit, the captain was slumped in his seat. Sitting beside him, copilot Eric Tellmann was starting to pass out. Tellmann managed to strap on his oxygen mask, then grabbed the captain's arm and forced him to follow suit. Reviving slowly, the captain looked at Tellmann through his mask, and his eyes grew wide with fear. A strange smell had permeated the plane that day. Passengers and flight attendants were coughing and wiping teary eyes. The pilots briefly lifted their masks and could still smell the odor as the runway drew nearer. Tellmann and the captain parked the Airbus A319 at the gate. But they had no memory of landing or taxiing Spirit Airlines Flight 708. Tellmann went to the hospital for treatment and spent the next week at home in bed, vomiting and shaking and feeling "like a freight train had run over us," he said in a letter to his union about the July 2015 event. A mysterious smell. Strange symptoms. A trip to the emergency room. The signs were all there: Something had gone seriously wrong with the plane's air supply.

The air you breathe on airplanes comes directly from the jet engines. Known as bleed air, it is safe, unless there is a mechanical issue -- a faulty seal, for instance. When that happens, heated jet engine oil can leak into the air supply, potentially releasing toxic gases into the plane. For decades, the airline industry and its regulators have known about these incidents -- called fume events -- and have maintained that they are rare and that the toxic chemical levels are too low to pose serious health risks. But a Times investigation found that vapors from oil and other fluids seep into planes with alarming frequency across all airlines, at times creating chaos and confusion: Flight attendants vomit and pass out. Passengers struggle to breathe. Children get rushed to hospitals. Pilots reach for oxygen masks or gasp for air from opened cockpit windows. Such events are documented in airport paramedic records, NASA safety reports, federal aviation records and other filings reviewed by The Times. Tellmann, the Spirit Airlines pilot, was one of hundreds of airline crew members and passengers who reported being sickened or impaired on flights in recent years. A Times analysis of NASA safety reports from January 2018 to December 2019 identified 362 fume events that airline crew members reported to the agency, with nearly 400 pilots, flight attendants and passengers receiving medical attention. During at least 73 of those flights, pilots used emergency oxygen. Four dozen pilots were described as impaired to the point of being unable to perform their duties. Because they're made voluntarily, the NASA safety reports are the "tip of the iceberg," according to a recent study by a researcher from the National Institute for Occupational Safety and Health.

A new article examines a study which suggested fresh asphalt is "a significant, yet overlooked, source of air pollution," (as reported by Science). "In fact, the material's contribution to one kind of particulate air pollution could rival or even exceed that of cars and trucks."

UPI reports: And its emissions double as its temperature increases from 104 to 140 degrees Fahrenheit, researchers found. Sunlight plays a key role in these asphalt emissions, with even moderate levels of sunshine tripling the release of air pollutants, according to the study published Sept. 2 in the journal Science Advances... In-use pavement usually gets as hot as between 117 and 153 degrees Fahrenheit in the summer, while roofs can reach 167 degrees, the study authors said.

As the major contributors to air pollution get cut back — for example, through cleaner vehicle emissions — passive pollution sources like these will have a growing influence on the air we breathe, said Peter DeCarlo, an associate professor and air pollution expert with Johns Hopkins University, in Baltimore. "In doing that reduction, we are discovering these new sources that are now playing a more prominent role in our air pollution issues," DeCarlo said.... Asphalt probably contributes most to air pollution when it's freshly laid, DeCarlo added. During the paving process, asphalt is heated to as much as 248 to 320 degrees Fahrenheit, the researchers said. "If you've ever been around people laying asphalt, you smell it. It's clear something is getting into the air when that happens," DeCarlo said. But asphalt likely continues to emit air pollutants even after it's aged, when sunlight bakes the material, he noted.

Switching to concrete for paving would help reduce emissions, he said, but concrete is not an ideal paving material in all locales. Another possible solution might be the application of "cool pavement" technology, where colored sealants are applied to paved surfaces so they reflect more solar energy and become less likely to heat up, Gentner said. Emissions might also vary with different asphalt application methods and different formulations of the paving product, Gentner suggested.