AI

AI Boosts Research Careers But Flattens Scientific Discovery (ieee.org) 64

Ancient Slashdot reader erice shares the findings from a recent study showing that while AI helped researchers publish more often and boosted their careers, the resulting papers were, on average, less useful. "You have this conflict between individual incentives and science as a whole," says James Evans, a sociologist at the University of Chicago who led the study. From a recent IEEE Spectrum article: To quantify the effect, Evans and collaborators from the Beijing National Research Center for Information Science and Technology trained a natural language processing model to identify AI-augmented research across six natural science disciplines. Their dataset included 41.3 million English-language papers published between 1980 and 2025 in biology, chemistry, physics, medicine, materials science, and geology. They excluded fields such as computer science and mathematics that focus on developing AI methods themselves. The researchers traced the careers of individual scientists, examined how their papers accumulated attention, and zoomed out to consider how entire fields clustered or dispersed intellectually over time. They compared roughly 311,000 papers that incorporated AI in some way -- through the use of neural networks or large language models, for example -- with millions of others that did not.

The results revealed a striking trade-off. Scientists who adopt AI gain productivity and visibility: On average, they publish three times as many papers, receive nearly five times as many citations, and become team leaders a year or two earlier than those who do not. But when those papers are mapped in a high-dimensional "knowledge space," AI-heavy research occupies a smaller intellectual footprint, clusters more tightly around popular, data-rich problems, and generates weaker networks of follow-on engagement between studies. The pattern held across decades of AI development, spanning early machine learning, the rise of deep learning, and the current wave of generative AI. "If anything," Evans notes, "it's intensifying." [...] Aside from recent publishing distortions, Evans's analysis suggests that AI is largely automating the most tractable parts of science rather than expanding its frontiers.

Science

Doubt Cast On Discovery of Microplastics Throughout Human Body (theguardian.com) 50

An anonymous reader quotes a report from the Guardian: High-profile studies reporting the presence of microplastics throughout the human body have been thrown into doubt by scientists who say the discoveries are probably the result of contamination and false positives. One chemist called the concerns "a bombshell." Studies claiming to have revealed micro and nanoplastics in the brain, testes, placentas, arteries and elsewhere were reported by media across the world, including the Guardian.

There is no doubt that plastic pollution of the natural world is ubiquitous, and present in the food and drink we consume and the air we breathe. But the health damage potentially caused by microplastics and the chemicals they contain is unclear, and an explosion of research has taken off in this area in recent years. However, micro- and nanoplastic particles are tiny and at the limit of today's analytical techniques, especially in human tissue. There is no suggestion of malpractice, but researchers told the Guardian of their concern that the race to publish results, in some cases by groups with limited analytical expertise, has led to rushed results and routine scientific checks sometimes being overlooked.

The Guardian has identified seven studies that have been challenged by researchers publishing criticism in the respective journals, while a recent analysis listed 18 studies that it said had not considered that some human tissue can produce measurements easily confused with the signal given by common plastics. There is an increasing international focus on the need to control plastic pollution but faulty evidence on the level of microplastics in humans could lead to misguided regulations and policies, which is dangerous, researchers say. It could also help lobbyists for the plastics industry to dismiss real concerns by claiming they are unfounded. While researchers say analytical techniques are improving rapidly, the doubts over recent high-profile studies also raise the questions of what is really known today and how concerned people should be about microplastics in their bodies.

Social Networks

'NY Orders Apps To Lie About Social Media Addiction, Will Lose In Court' (techdirt.com) 38

New York Governor Kathy Hochul has signed S4505, a law that requires websites to display warnings claiming that features like algorithmic feeds, push notifications, infinite scroll, like counts, and autoplay cause addiction -- despite, as TechDirt argues, the absence of scientific consensus supporting such claims.

State Senator Andrew Gounardes sponsored the legislation. The law's constitutional footing appears precarious. Courts have already rejected nearly identical compelled-speech schemes, most notably in the Texas pornography age-verification case that reached the Supreme Court. The Fifth Circuit, in that case, refused to uphold mandatory health warnings about pornography, ruling that such public health claims were "too contentious and controversial to receive Zauderer scrutiny" -- the legal standard that sometimes permits government-mandated disclosures.

The science around social media's purported addictiveness is even more disputed than the pornography research the Fifth Circuit rejected. Hochul's signing statement asserts that studies link increased social media use to anxiety and depression, but researchers in the field note these studies demonstrate correlation rather than causation. Some experts have suggested the causal relationship may run in the opposite direction: teenagers struggling with mental health issues turn to social media for community and coping mechanisms. The law's broad definitions could sweep in far more than major platforms like Facebook and TikTok. News sites, recipe apps, fitness trackers, and email clients could theoretically face enforcement if they employ the targeted features. New York's Attorney General holds sole authority to grant exemptions.
The Almighty Buck

Economic Inequality Does Not Equate To Poor Well-Being or Mental Health, Massive Meta-Analysis Finds (nature.com) 127

A new sweeping meta-analysis has found no reliable link between economic inequality and well-being or mental health, challenging a long-held assumption that has shaped public health policy discussions for decades. The study, led by Nicolas Sommet at the University of Lausanne and Annahita Ehsan at the University of British Columbia, synthesized 168 studies involving more than 11 million participants across most world regions. The researchers screened thousands of scientific papers and contacted hundreds of researchers to compile the dataset, extracting more than 100 study features from each paper and linking them to more than 500 World Bank indicators.

They also replicated their findings using Gallup World Poll data spanning 2005 to 2021, which surveyed more than two million respondents from more than 150 countries. People living in more economically unequal places did not, on average, report lower life satisfaction or happiness than those in more equal places. The average effect across studies was not statistically significant and was practically equivalent to zero. Studies that did find links between inequality and poorer mental health turned out to reflect publication bias, where small, noisy studies reporting larger effects were over-represented in the literature. The study adds: Further analyses showed that the near-zero averages conceal more-complex patterns. Greater income inequality was associated with lower well-being in high-inflation contexts and, surprisingly, higher well-being in low-inflation contexts. Greater inequality was also associated with poorer mental health in studies in which the average income was lower. We conclude that inequality is a catalyst that amplifies other determinants of well-being and mental health (such as inflation and poverty) but on its own is not a root cause of negative effects on well-being and mental health.
Beer

Heart Association Revives Theory That Light Drinking May Be Good For You 96

An anonymous reader quotes a report from the New York Times: For a while, it seemed the notion that light drinking was good for the heart had gone by the wayside, debunked by new studies and overshadowed by warnings that alcohol causes cancer. Now the American Heart Association has revived the idea in a scientific review that is drawing intense criticism, setting off a new round of debate about alcohol consumption. The paper, which sought to summarize the latest research and was aimed at practicing cardiologists, concluded that light drinking -- one to two drinks a day -- posed no risk for coronary disease, stroke, sudden death and possibly heart failure, and may even reduce the risk of developing these conditions.

Controversy over the influential organization's review has been simmering since it was published in the association's journal Circulation in July. Public health groups and many doctors have warned on the basis of recent studies that alcohol can be harmful even in small amounts. Groups like the European Heart Network and the World Heart Federation have stressed that even modest drinking increases the odds of cardiovascular disease.
"It says in all our guidelines right now, 'If you don't drink, don't start.' There's not enough evidence to suggest conclusively that it prevents heart disease," said Dr. Mariell Jessup, the chief science and medical officer at the heart association, adding that the review was not meant to serve as a guideline and that the group's advice to patients has not changed.

Critics argue that suggesting any heart-health benefits from alcohol is dangerous given its well-documented risks, and they accuse the heart association of selectively weighing studies. They also say a past tie to the alcohol industry by one author should have disqualified him from participating.

"The cardiovascular benefits of moderate drinking are questionable at best," said Dr. Elizabeth Farkouh, an internist and alcohol researcher. "But even if there was a benefit, there are so many other ways to reduce cardiovascular risk that don't come with an associated cancer risk."

The new review's conclusion is also at odds with the CDC's guidance on alcohol, which notes that "even moderate drinking may increase your risk of death and other alcohol-related harms, compared to not drinking." It also seems to diverge from the heart association's diet and lifestyle recommendation to consume "limited or preferably no alcohol," along with its 2023 statement that recent research suggests there is "no safe level of alcohol use."
Medicine

Science Journal Retracts Study On Safety of Monsanto's Roundup (theguardian.com) 44

An anonymous reader quotes a report from the Guardian: The journal Regulatory Toxicology and Pharmacology has formally retracted a sweeping scientific paper published in 2000 that became a key defense for Monsanto's claim that Roundup herbicide and its active ingredient glyphosate don't cause cancer. Martin van den Berg, the journal's editor in chief, said in a note accompanying the retraction that he had taken the step because of "serious ethical concerns regarding the independence and accountability of the authors of this article and the academic integrity of the carcinogenicity studies presented."

The paper, titled Safety Evaluation and Risk Assessment of the Herbicide Roundup and Its Active Ingredient, Glyphosate, for Humans, concluded that Monsanto's glyphosate-based weed killers posed no health risks to humans -- no cancer risks, no reproductive risks, no adverse effects on development of endocrine systems in people or animals. Regulators around the world have cited the paper as evidence of the safety of glyphosate herbicides, including the Environmental Protection Agency (EPA) in this assessment (PDF). [...]

In explaining the decision to retract the 25-year-old research paper, Van den Berg wrote: "Concerns were raised regarding the authorship of this paper, validity of the research findings in the context of misrepresentation of the contributions by the authors and the study sponsor and potential conflicts of interest of the authors." He noted that the paper's conclusions regarding the carcinogenicity of glyphosate were solely based on unpublished studies from Monsanto, ignoring other outside, published research.
"The retraction of this study is a long time coming," said Brent Wisner, one of the lead lawyers in the Roundup litigation and a key player in getting the internal documents revealed to the public. Wisner said the study was the "quintessential example of how companies like Monsanto could fundamentally undermine the peer-review process through ghostwriting, cherrypicking unpublished studies, and biased interpretations."

"This garbage ghostwritten study finally got the fate it deserved,â Wisner added. "Hopefully, journals will now be more vigilant in protecting the impartiality of science on which so many people depend."
Supercomputing

A Quantum Error Correction Breakthrough? (harvard.edu) 39

The dream of quantum computers has been hampered by the challenge of error correction, writes the Harvard Gazette, since qubits "are inherently susceptible to slipping out of their quantum states and losing their encoded information."

But in a newly-published paper, a research team "combined various methods to create complex circuits with dozens of error correction layers" that "suppresses errors below a critical threshold — the point where adding qubits further reduces errors rather than increasing them." "For the first time, we combined all essential elements for a scalable, error-corrected quantum computation in an integrated architecture," said Mikhail Lukin, co-director of the Quantum Science and Engineering Initiative, Joshua and Beth Friedman University Professor, and senior author of the new paper. "These experiments — by several measures the most advanced that have been done on any quantum platform to date — create the scientific foundation for practical large-scale quantum computation..."

"There are still a lot of technical challenges remaining to get to very large-scale computer with millions of qubits, but this is the first time we have an architecture that is conceptually scalable," said lead author Dolev Bluvstein, Ph.D. '25, who did the research during his graduate studies at Harvard and is now an assistant professor at Caltech. "It's going to take a lot of effort and technical development, but it's becoming clear that we can build fault-tolerant quantum computers...."

Hartmut Neven, vice president of engineering at the Google Quantum AI team, said the new paper came amid an "incredibly exciting" race between qubit platforms. "This work represents a significant advance toward our shared goal of building a large-scale, useful quantum computer," he said... With recent advances, Lukin believes the core elements for building quantum computers are falling into place. "This big dream that many of us had for several decades, for the first time, is really in direct sight," he said.

"In theory, a system of 300 quantum bits can store more information than the number of particles in the known universe..." the article points out.

"The new paper represents an important advance in a three-decade pursuit of quantum error correction."

Thanks to long-time Slashdot reader schwit1 for sharing the article.
Books

Can Cory Doctorow's 'Enshittification' Transform the Tech Industry Debate? (nytimes.com) 76

An anonymous reader quotes a report from the New York Times: Over the course of a nearly four-decade career, Cory Doctorow has written 15 novels, four graphic novels, dozens of short stories, six nonfiction books, approximately 60,000 blog posts and thousands of essays. And yet for all the millions of words he's published, these days the award-winning science fiction author and veteran internet activist is best known for just a single one: Enshittification. The term, which Doctorow, 54, popularized in essays in 2022 and 2023, refers to the way that online platforms become worse to use over time, as the corporations that own them try to make more money. Though the coinage is cheeky, in Doctorow's telling the phenomenon it describes is a specific, nearly scientific process that progresses according to discrete stages, like a disease.

Since then, the meaning has expanded to encompass a general vibe -- a feeling far greater than frustration at Facebook, which long ago ceased being a good way to connect with friends, or Google, whose search is now baggy with SEO spam. Of late, the idea has been employed to describe everything from video games to television to American democracy itself. "It's frustrating. It's demoralizing. It's even terrifying," Doctorow said in a 2024 speech. On Tuesday, Farrar Straus & Giroux will release "Enshittification: Why Everything Suddenly Got Worse and What to Do About It," Doctorow's book-length elaboration on his essays, complete with case studies (Uber, Twitter, Photoshop) and his prescriptions for change, which revolve around breaking up big tech companies and regulating them more robustly.
Further reading: The Enshittification Hall of Shame
Science

Microplastics Could Be Weakening Your Bones, Research Suggests (wired.com) 9

A review of 62 scientific studies published in Osteoporosis International found that microplastics weaken bones by disrupting bone marrow stem cells and stimulating osteoclasts, cells that degrade bone tissue. Laboratory experiments found the particles reduce cell viability, induce premature cellular aging, modify gene expression, and trigger inflammatory responses. Animal studies found microplastic accumulation decreases white blood cell counts and deteriorates bone microstructure, creating irregular cell structures that increase fracture risk. Rodrigo Bueno de Oliveira from the State University of Campinas in Brazil said the effects interrupted skeletal growth in test animals.
AI

Journals Infiltrated With 'Copycat' Papers That Can Be Written By AI (nature.com) 34

An analysis of a literature database finds that text-generating AI tools -- including ChatGPT and Gemini -- can be used to rewrite scientific papers and produce 'copycat' versions that are then passed off as new research. Nature: In a preprint posted on medRxiv on 12 September, researchers identified more than 400 such papers published in 112 journals over the past 4.5 years, and demonstrated that AI-generated biomedicine studies could evade publishers' anti-plagiarism checks.

The study's authors warn that individuals and paper mills -- companies that produce fake papers to order and sell authorships -- might be exploiting publicly available health data sets and using large language models (LLMs) to mass-produce low-quality papers that lack scientific value.

"If left unaddressed, this AI-based approach can be applied to all sorts of open-access databases, generating far more papers than anyone can imagine," says Csaba Szabo, a pharmacologist at the University of Fribourg in Switzerland, who was not involved in the work. "This could open up Pandora's box [and] the literature may be flooded with synthetic papers."

Biotech

Scientists Discuss Next Steps to Prevent Dangerous 'Mirror Life' Research (msn.com) 90

USA Today has an update on the curtailing of "mirror life" research: Kate Adamala had been working on something dangerous. At her synthetic biology lab, Adamala had been taking preliminary steps toward creating a living cell from scratch with one key twist: All the organism's building blocks would be flipped. Changing these molecules would create an unnatural mirror image of a cell, as different as your right hand from your left. The endeavor was not only a fascinating research challenge, but it also could be used to improve biotechnology and medicine. As Adamala and her colleagues talked with biosecurity experts about the project, however, grave concerns began brewing. "They started to ask questions like, 'Have you considered what happens if that cell gets released or what would happen if it infected a human?'" said Adamala, an associate professor at the University of Minnesota. They hadn't.

So researchers brought together dozens of experts in a variety of disciplines from around the globe, including two Nobel laureates, who worked for months to determine the risks of creating "mirror life" and the chances those dangers could be mitigated. Ultimately, they concluded, mirror cells could inflict "unprecedented and irreversible harm" on our world. "We cannot rule out a scenario in which a mirror bacterium acts as an invasive species across many ecosystems, causing pervasive lethal infections in a substantial fraction of plant and animal species, including humans," the scientists wrote in a paper published in the journal Science in December alongside a 299-page technical report...

[Report co-author Vaughn Cooper, a professor at the University of Pittsburgh who studies how bacteria adapt to new environments] said it's not yet possible to build a cell from scratch, mirror or otherwise, but researchers have begun the process by synthesizing mirror proteins and enzymes. He and his colleagues estimated that given enough resources and manpower, scientists could create a complete mirror bacteria within a decade. But for now, the world is probably safe from mirror cells. Adamala said virtually everyone in the small scientific community that was interested in developing such cells has agreed not to as a result of the findings.

The paper prompted nearly 100 scientists and ethicists from around the world to gather in Paris in June to further discuss the risks of creating mirror organisms. Many felt self-regulation is not enough, according to the institution that hosted the event, and researchers are gearing up to meet again in Manchester, England, and Singapore to discuss next steps.

AI

Autonomous AI-Guided Black Hawk Helicopter Tested to Fight Wildfires (yahoo.com) 36

Imagine this. Lightning sparks a wildfire, but "within seconds, a satellite dish swirling overhead picks up on the anomaly and triggers an alarm," writes the Los Angeles Times. "An autonomous helicopter takes flight and zooms toward the fire, using sensors to locate the blaze and AI to generate a plan of attack. It measures the wind speed and fire movement, communicating constantly with the unmanned helicopter behind it, and the one behind that. Once over the site, it drops a load of water and soon the flames are smoldering. Without deploying a single human, the fire never grows larger than 10 square feet.

"This is the future of firefighting." On a recent morning in San Bernardino, state and local fire experts gathered for a demonstration of the early iterations of this new reality. An autonomous Sikorski Black Hawk helicopter, powered by technology from Lockheed Martin and a California-based software company called Rain, is on display on the tarmac of a logistics airport in Victorville — the word "EXPERIMENTAL" painted on its military green-black door. It's one of many new tools on the front lines of firefighting technology, which experts say is evolving rapidly as private industry and government agencies come face-to-face with a worsening global climate crisis...

Scientific studies and climate research models have found that the number of extreme fires could increase by as much as 30% globally by 2050. By 2100, California alone could see a 50% increase in wildfire frequency and a 77% increase in average annual acres burned, according to the state's most recent climate report. That's largely because human-caused climate change is driving up temperatures and drying out the landscape, priming it to burn, according to Kate Dargan Marquis, a senior advisor with the Gordon and Betty Moore Foundation who served as California's state fire marshal from 2007 to 2010.... "[T]he policies of today and the technologies of today are not going to serve us tomorrow."

Today, more than 1,100 mountaintop cameras positioned across California are already using artificial intelligence to scan the landscape for the first sign of flames and prompt crews to spring into action. NASA's Earth-observing satellites are studying landscape conditions to help better predict fires before they ignite, while a new global satellite constellation recently launched by Google is helping to detect fires faster than ever before.

One 35-year fire service veteran who consults on fire service technologies even predicts fire-fighting robots will also be used in high-risk situations like the Colossus robot that battled flames searing through Notre-Dame Cathedral in Paris...

And a bill moving through California's legislation "would direct the California Department of Forestry and Fire Protection to establish a pilot program to assess the viability of incorporating autonomous firefighting helicopters in the state."
Science

Fraudulent Scientific Papers Are Rapidly Increasing, Study Finds (nytimes.com) 74

For years, whistle-blowers have warned that fake results are sneaking into the scientific literature at an increasing pace. A new statistical analysis backs up the concern. From a report: A team of researchers found evidence of shady organizations churning out fake or low-quality studies on an industrial scale. And their output is rising fast, threatening the integrity of many fields.

"If these trends are not stopped, science is going to be destroyed," said LuÃs A. Nunes Amaral, a data scientist at Northwestern University and an author of the study, which was published in the Proceedings of the National Academy of Sciences on Monday. Science has made huge advances over the past few centuries only because new generations of scientists could read about the accomplishments of previous ones. Each time a new paper is published, other scientists can explore the findings and think about how to make their own discoveries.
Fake scientific papers produced by commercial "paper mills" are doubling every year and a half, according to the report. Northwestern University researchers examined over one million papers and identified networks of fraudulent studies sold to scientists seeking to pad their publication records. The team estimates the actual scope of fraud may be 100 times greater than currently detected cases. Paper mills charge hundreds to thousands of dollars for fake authorship and often target specific research fields like microRNA cancer studies.
Earth

Researchers Quietly Planned a Test to Dim Sunlight Over 3,900 Square Miles (politico.com) 81

California researchers planned a multimillion-dollar test of salt water-spraying equipment that could one day be used to dim the sun's rays — over a 3,900-square mile are off the west coasts of North America, Chile or south-central Africa. E&E News calls it part of a "secretive" initiative backed by "wealthy philanthropists with ties to Wall Street and Silicon Valley" — and a piece of the "vast scope of research aimed at finding ways to counter the Earth's warming, work that has often occurred outside public view." "At such scales, meaningful changes in clouds will be readily detectable from space," said a 2023 research plan from the [University of Washington's] Marine Cloud Brightening Program. The massive experiment would have been contingent upon the successful completion of the thwarted pilot test on the carrier deck in Alameda, according to the plan.... Before the setback in Alameda, the team had received some federal funding and hoped to gain access to government ships and planes, the documents show.

The university and its partners — a solar geoengineering research advocacy group called SilverLining and the scientific nonprofit SRI International — didn't respond to detailed questions about the status of the larger cloud experiment. But SilverLining's executive director, Kelly Wanser, said in an email that the Marine Cloud Brightening Program aimed to "fill gaps in the information" needed to determine if the technologies are safe and effective.âIn the initial experiment, the researchers appeared to have disregarded past lessons about building community support for studies related to altering the climate, and instead kept their plans from the public and lawmakers until the testing was underway, some solar geoengineering experts told E&E News. The experts also expressed surprise at the size of the planned second experiment....

The program does not "recommend, support or develop plans for the use of marine cloud brightening to alter weather or climate," Sarah Doherty, an atmospheric and climate science professor at the university who leads the program, said in a statement to E&E News. She emphasized that the program remains focused on researching the technology, not deploying it. There are no "plans for conducting large-scale studies that would alter weather or climate," she added.

"More than 575 scientists have called for a ban on geoengineering development," according to the article, "because it 'cannot be governed globally in a fair, inclusive, and effective manner.'" But "Some scientists believe that the perils of climate change are too dire to not pursue the technology, which they say can be safely tested in well-designed experiments... " "If we really were serious about the idea that to do any controversial topic needs some kind of large-scale consensus before we can research the topic, I think that means we don't research topics," David Keith, a geophysical sciences professor at the University of Chicago, said at a think tank discussion last month... "The studies that the program is pursuing are scientifically sound and would be unlikely to alter weather patterns — even for the Puerto Rico-sized test, said Daniele Visioni, a professor of atmospheric sciences at Cornell University. Nearly 30 percent of the planet is already covered by clouds, he noted.
Thanks to Slashdot reader fjo3 for sharing the news.
Science

Quality of Scientific Papers Questioned as Academics 'Overwhelmed' By the Millions Published (theguardian.com) 39

A scientific paper featuring an AI-generated image of a rat with an oversized penis was retracted three days after publication, highlighting broader problems plaguing academic publishing as researchers struggle with an explosion of scientific literature. The paper appeared in Frontiers in Cell and Developmental Biology before widespread mockery forced its withdrawal.

Research studies indexed on Clarivate's Web of Science database increased 48% between 2015 and 2024, rising from 1.71 million to 2.53 million papers. Nobel laureate Venki Ramakrishnan called the publishing system "broken and unsustainable," while University of Exeter researcher Mark Hanson described scientists as "increasingly overwhelmed" by the volume of articles. The Royal Society plans to release a major review of scientific publishing disruptions at summer's end, with former government chief scientist Mark Walport citing incentives that favor quantity over quality as a fundamental problem.
Medicine

Weedkiller Ingredient Widely Used In US Can Damage Organs and Gut Bacteria, Research Shows (theguardian.com) 85

An anonymous reader quotes a report from The Guardian: The herbicide ingredient used to replace glyphosate in Roundup and other weedkiller products can kill gut bacteria and damage organs in multiple ways, new research shows. The ingredient, diquat, is widely employed in the US as a weedkiller in vineyards and orchards, and is increasingly sprayed elsewhere as the use of controversial herbicide substances such as glyphosate and paraquat drops in the US. But the new piece of data suggests diquat is more toxic than glyphosate, and the substance is banned over its risks in the UK, EU, China and many other countries. Still, the EPA has resisted calls for a ban, and Roundup formulas with the ingredient hit the shelves last year. [...]

Diquat is also thought to be a neurotoxin, carcinogen and linked to Parkinson's disease. An October analysis of EPA data by the Friends of the Earth non-profit found it is about 200 times more toxic than glyphosate in terms of chronic exposure. [...] The new review of scientific literature in part focuses on the multiple ways in which diquat damages organs and gut bacteria, including by reducing the level of proteins that are key pieces of the gut lining. The weakening can allow toxins and pathogens to move from the stomach into the bloodstream, and trigger inflammation in the intestines and throughout the body. Meanwhile, diquat can inhibit the production of beneficial bacteria that maintain the gut lining. Damage to the lining also inhibits the absorption of nutrients and energy metabolism, the authors said.

The research further scrutinizes how the substance harms the kidneys, lungs and liver. Diquat "causes irreversible structural and functional damage to the kidneys" because it can destroy kidney cells' membranes and interfere with cell signals. The effects on the liver are similar, and the ingredient causes the production of proteins that inflame the organ. Meanwhile, it seems to attack the lungs by triggering inflammation that damages the organ's tissue. More broadly, the inflammation caused by diquat may cause multiple organ dysfunction syndrome, a scenario in which organ systems begin to fail. The authors note that many of the studies are on rodents and more research on low, long-term exposure is needed.
The report notes that the EPA is not reviewing the chemical, "and even non-profits that push for tighter pesticide regulations have largely focused their attention elsewhere."

"[T]hat was in part because U.S. pesticide regulations are so weak that advocates are tied up with battles over ingredients like glyphosate, paraquat and chlorpyrifos -- substances that are banned elsewhere but still widely used here. Diquat is 'overshadowed' by those ingredients."
Earth

Global Warming Is Speeding Up and the World Is Feeling the Effects 149

An anonymous reader shares a report: Summer started barely a week ago, and already the United States has been smothered in a record-breaking "heat dome." Alaska saw its first-ever heat advisory this month. And all of this comes on the heels of 2024, the hottest calendar year in recorded history. The world is getting hotter, faster. A report published last week found that human-caused global warming is now increasing by 0.27 degrees Celsius per decade. That rate was recorded at 0.2 degrees in the 1970s, and has been growing since.

"Each additional fractional degree of warming brings about a relatively larger increase in atmospheric extremes, like extreme downpours and severe droughts and wildfires," said Daniel Swain, a climate scientist at the University of California. While this aligns with scientific predictions of how climate change can intensify such events, the increase in severity may feel sudden to people who experience them.

"Back when we had lesser levels of warming, that relationship was a little bit less dramatic," Dr. Swain said. "There is growing evidence that the most extreme extremes probably will increase faster and to a greater extent than we used to think was the case," he added. Take rainfall, for example. Generally, extreme rainfall is intensifying at a rate of 7 percent with each degree Celsius of atmospheric warming. But recent studies indicate that so-called record-shattering events are increasing at double that rate, Dr. Swain said.
ISS

India To Send First Astronaut On Mission To ISS (theguardian.com) 14

Shubhanshu Shukla will become the first Indian astronaut to visit the International Space Station as part of a four-person mission by Axiom Space launching from the U.S.. The mission will include 14 days aboard the ISS and over 60 scientific studies. The Guardian reports: He will be the third astronaut of Indian origin to reach orbit, following Rakesh Sharma, who was part of a 1984 flight onboard a Soviet Soyuz spacecraft, and Kalpana Chawla, who was born in India but became a US citizen and flew on two space shuttle missions, including the 2003 Columbia flight that ended in disaster when the spacecraft disintegrated, killing all seven astronauts onboard. "I truly believe that even though, as an individual, I am traveling to space, this is the journey of 1.4 billion people," Shukla was quoted as saying by the Hindu newspaper this year. Shukla said he hoped to "ignite the curiosity of an entire generation in my country."

India's department of space has called the trip a "defining chapter" in its ambitious space exploration program. The International Space Station mission (ISS) "stands as a symbol of a confident, forward-looking nation ready to reclaim its place in the global space race," the agency said before the launch. "His journey is more than just a flight -- it's a signal that India is stepping boldly into a new era of space exploration." New Delhi has paid more than $60m for the mission, according to Indian media reports. [...]

Shukla trained at the Yuri Gagarin Cosmonaut Training Center in Russia in 2020, before undertaking further training at the ISRO's centre in Bengaluru. He has said the journey aboard the Axiom Mission 4, and the expected 14 days on the ISS, will provide "invaluable" lessons to bring back home. Shukla will be led by the mission commander, Peggy Whitson, a former Nasa astronaut and an Axiom employee, and joined by the European Space Agency astronaut Slawosz Uznanski-Wisniewski, of Poland, and Tibor Kapu, of Hungary. They will conduct 60 scientific studies, including microgravity research, earth observation, and life, biological and material sciences experiments.

Biotech

Uploading the Human Mind Could One Day Become a Reality, Predicts Neuroscientist (sciencealert.com) 107

A 15-year-old asked the question — receiving an answer from an associate professor of psychology at Georgia Institute of Technology. They write (on The Conversation) that "As a brain scientist who studies perception, I fully expect mind uploading to one day be a reality.

"But as of today, we're nowhere close..." Replicating all that complexity will be extraordinarily difficult. One requirement: The uploaded brain needs the same inputs it always had. In other words, the external world must be available to it. Even cloistered inside a computer, you would still need a simulation of your senses, a reproduction of the ability to see, hear, smell, touch, feel — as well as move, blink, detect your heart rate, set your circadian rhythm and do thousands of other things... For now, researchers don't have the computing power, much less the scientific knowledge, to perform such simulations.

The first task for a successful mind upload: Scanning, then mapping the complete 3D structure of the human brain. This requires the equivalent of an extraordinarily sophisticated MRI machine that could detail the brain in an advanced way. At the moment, scientists are only at the very early stages of brain mapping — which includes the entire brain of a fly and tiny portions of a mouse brain. In a few decades, a complete map of the human brain may be possible. Yet even capturing the identities of all 86 billion neurons, all smaller than a pinhead, plus their trillions of connections, still isn't enough. Uploading this information by itself into a computer won't accomplish much. That's because each neuron constantly adjusts its functioning, and that has to be modeled, too. It's hard to know how many levels down researchers must go to make the simulated brain work. Is it enough to stop at the molecular level? Right now, no one knows.

Knowing how the brain computes things might provide a shortcut. That would let researchers simulate only the essential parts of the brain, and not all biological idiosyncrasies. Here's another way: Replace the 86 billion real neurons with artificial ones, one at a time. That approach would make mind uploading much easier. Right now, though, scientists can't replace even a single real neuron with an artificial one. But keep in mind the pace of technology is accelerating exponentially. It's reasonable to expect spectacular improvements in computing power and artificial intelligence in the coming decades.

One other thing is certain: Mind uploading will certainly have no problem finding funding. Many billionaires appear glad to part with lots of their money for a shot at living forever. Although the challenges are enormous and the path forward uncertain, I believe that one day, mind uploading will be a reality.

"The most optimistic forecasts pinpoint the year 2045, only 20 years from now. Others say the end of this century.

"But in my mind, both of these predictions are probably too optimistic. I would be shocked if mind uploading works in the next 100 years.

"But it might happen in 200..."
Earth

Why 200 US Climate Scientists are Hosting a 100-Hour YouTube Livestream (space.com) 133

"More than 200 climate and weather scientists from across the U.S. are taking part in a marathon livestream on YouTube," according to this report from Space.com. For 100 hours (that started Wednesday) they're sharing their scientific work and answering questions from viewers, "to prove the value of climate science," according to the article.

The event is being stated in protest of recent government funding cuts at NASA, the National Oceanic and Atmospheric Administration, the United States Geological Survey, and the National Science Foundation. (The event began with "scientists documenting their last few hours at NASA's Goddard Institute for Space Studies as the office was shuttered.") The marathon stream features mini-lectures, panels and question-and-answer sessions with hundreds of scientists, each speaking in their capacity as private citizens rather than on behalf of any institution. These include talks from former National Weather Service directors, Britney Schmidt, a groundbreaking glacier researcher, and legendary meteorologist John Morales.

In its first 30 hours, the stream got over 77,000 views.

Ultimately, the goal of the event is to give members of the public the chance to learn more about meteorology and climate science in an informal setting — and for free. "We really felt like the American public deserves to know what we do," Duffy said. However, many of the speakers and organizers also hope the transference of this knowledge will spur people to take action. The event's website features a link to 5 Calls, an organization that makes it easy for folks to contact their representatives in Congress about the importance of funding climate and weather research.

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