Doctors have long relied on a few key patient characteristics to assess risk of a heart attack or stroke, using a calculus that considers blood pressure, cholesterol, smoking and diabetes status, as well as demographics: age, sex and race. Now, the American Heart Association is taking race out of the equation. From a report: The overhaul of the widely used cardiac-risk algorithm is an acknowledgment that, unlike sex or age, race identification in and of itself is not a biological risk factor. The scientists who modified the algorithm decided from the start that race itself did not belong in clinical tools used to guide medical decision making, even though race might serve as a proxy for certain social circumstances, genetic predispositions or environmental exposures that raise the risk of cardiovascular disease.

The revision comes amid rising concern about health equity and racial bias within the U.S. health care system, and is part of a broader trend toward removing race from a variety of clinical algorithms. "We should not be using race to inform whether someone gets a treatment or doesn't get a treatment," said Dr. Sadiya Khan, a preventive cardiologist at Northwestern University Feinberg School of Medicine, who chaired the statement writing committee for the American Heart Association, or A.H.A. The statement was published on Friday [PDF] in the association's journal, Circulation. An online calculator using the new algorithm, called PREVENT, is still in development.

Cambridge dictionary's word of the year for 2023 is "hallucinate," a verb that took on a new meaning with the rise in popularity of artificial intelligence chatbots. The Guardian reports: The original definition of the chosen word is to "seem to see, hear, feel, or smell" something that does not exist, usually because of "a health condition or because you have taken a drug." It now has an additional meaning, relating to when artificial intelligence systems such as ChatGPT, which generates text that mimics human writing, "hallucinates" and produces false information. The word was chosen because the new meaning "gets to the heart of why people are talking about AI," according to a post on the dictionary site.

Generative AI is a "powerful" but "far from perfect" tool, "one we're all still learning how to interact with safely and effectively -- this means being aware of both its potential strengths and its current weaknesses." The dictionary added a number of AI-related entries this year, including large language model (or LLM), generative AI (or GenAI), and GPT (an abbreviation of Generative Pre-trained Transformer). "AI hallucinations remind us that humans still need to bring their critical thinking skills to the use of these tools," continued the post. "Large language models are only as reliable as the information their algorithms learn from. Human expertise is arguably more important than ever, to create the authoritative and up-to-date information that LLMs can be trained on."

samleecole writes: People who paid to speak to an AI girlfriend modeled after real life 23-year-old influencer Caryn Marjorie are distraught because the service they paid for, Forever Companions, no longer works. It appears that the service stopped working shortly after Forever Companion CEO and founder John Meyer was arrested for trying to set his own apartment on fire.

404 Media tested CarynAI today as well as other AI bots and confirmed the service is not working. According to what we saw in the Telegram channel where Forever Companion users start conversations with CarynAI, the service has not been working since October 23. "I terminated my relationship with Forever Voices due to unforeseen circumstances," Marjorie told 404 Media in an email. "I wish the best for John Meyer and his family as he recovers from his mental health crisis. We didn't see this coming but I vow to push CarynAI forward for my fans and supporters." On October 30, Marjorie also announced that she's making a similar AI companion, "CarynAI 2.0," with another company called Banter AI. On social media for the last few weeks, the official Forever Voices Twitter account has been posting bizarre videos and statements about the CIA, Donald Trump, and the FBI.

An anonymous reader quotes a report from NBC News: A prolonged decline in male fertility in the form of sperm concentrations appears to be connected to the use of pesticides, according to a study published Wednesday. Researchers compiled, rated and reviewed the results of 25 studies of certain pesticides and male fertility and found that men who had been exposed to certain classes of pesticides had significantly lower sperm concentrations. The study, published Wednesday in Environmental Health Perspectives, included data from more than 1,700 men and spanned several decades. "No matter how we looked at the analysis and results, we saw a persistent association between increasing levels of insecticide and decreases in sperm concentration," said study author Melissa Perry, who is an environmental epidemiologist and the dean of the College of Public Health at George Mason University. "I would hope this study would get the attention of regulators seeking to make decisions to keep the public safe from inadvertent, unplanned impacts of insecticides." [...]

Scientists have long suspected changes to the environment could be contributing, and they've been probing the role of pesticides for decades in studies of animals and in human epidemiology research. The new analysis focuses on two groups of chemicals -- organophosphates and some carbamates -- that are commonly used in insecticides. The researchers looked at data collected from groups of people with exposures to pesticides and others who were not. Most, but not all, of the research centered on exposures in the workplace. The researchers controlled for outside factors that could contribute to lower sperm counts like smoking and age. Perry said researchers aren't sure how pesticides are affecting sperm concentrations and more research will be needed.

It's likely that pesticides are one of many environmental factors that could be contributing to a decline in sperm concentrations. The trend of sperm concentration declines has been widely observed in studies around the world, but it's a complicated topic and some scientists still have reservations. Sperm are notoriously difficult to count and the technology to do so has changed over the years. There are many confounding factors that can affect male fertility, including age, obesity and opioid use, to name a few. Sperm concentrations are one important data point to consider, but other factors -- like how sperm are shaped and how they swim -- are also critical to male fertility. Perry said she hopes agencies like the Environmental Protection Agency begin to factor the impact of chemicals and pesticides on reproductive health in their assessments. "Given the body of evidence and these consistent findings, it's time to proactively reduce these insecticide exposures for men wanting to have families," Perry said.

Amazon said on Wednesday that it was removing seven eyedrops products from its website after the Food and Drug Administration warned the company that the eyedrops had not been recognized as safe and effective. From a report: The F.D.A. said in a letter to Andrew Jassy, Amazon's chief executive, on Monday that Amazon had violated federal regulations by selling the eyedrops, which claimed to help with problems including pink eye, dry eyes, eyestrain and floaters. "These products are especially concerning from a public health perspective," the F.D.A. letter said. "Ophthalmic drug products, which are intended for administration into the eyes, in general pose a greater risk of harm to users because the route of administration for these products bypasses some of the body's natural defenses."

The eyedrops named in the letter are: Similasan Pink Eye Relief, The Goodbye Company Pink Eye, Can-C Eye Drops, Optique 1 Eye Drops, OcluMed Eye Drops, TRP Natural Eyes Floaters Relief, and Manzanilla Sophia Chamomile Herbal Eye Drops. None of the eyedrops appeared to be available for purchase on Amazon on Wednesday morning. The company said in an emailed statement on Wednesday that "safety is a top priority."

Emma Roth reports via The Verge: Meta, ByteDance, Alphabet, and Snap must proceed with a lawsuit alleging their social platforms have adverse mental health effects on children, a federal court ruled on Tuesday. US District Judge Yvonne Gonzalez Rogers rejected the social media giants' motion to dismiss the dozens of lawsuits accusing the companies of running platforms "addictive" to kids. School districts across the US have filed suit against Meta, ByteDance, Alphabet, and Snap, alleging the companies cause physical and emotional harm to children. Meanwhile, 42 states sued Meta last month over claims Facebook and Instagram "profoundly altered the psychological and social realities of a generation of young Americans." This order addresses the individual suits and "over 140 actions" taken against the companies.

Tuesday's ruling states that the First Amendment and Section 230, which says online platforms shouldn't be treated as the publishers of third-party content, don't shield Facebook, Instagram, YouTube, TikTok, and Snapchat from all liability in this case. Judge Gonzalez Rogers notes many of the claims laid out by the plaintiffs don't "constitute free speech or expression," as they have to do with alleged "defects" on the platforms themselves. That includes having insufficient parental controls, no "robust" age verification systems, and a difficult account deletion process.

"Addressing these defects would not require that defendants change how or what speech they disseminate," Judge Gonzalez Rogers writes. "For example, parental notifications could plausibly empower parents to limit their children's access to the platform or discuss platform use with them." However, Judge Gonzalez Rogers still threw out some of the other "defects" identified by the plaintiffs because they're protected under Section 230, such as offering a beginning and end to a feed, recommending children's accounts to adults, the use of "addictive" algorithms, and not putting limits on the amount of time spent on the platforms.

A person linked to a scam that tricked an elderly victim into transferring more than $100,000 formally requested the FBI give back his seized cryptocurrency, claiming in a petition to the agency that he is a part-time crypto investor and not doing anything illegal, according to a recently filed court record. From a report: 404 Media also reached the person by email and they largely repeated the same story. The request is an unusual sight, and, to be frank, probably not going to work. In the court record, authorities allege that the frozen funds are linked to a scam of a victim in the U.S. The document says authorities seized just under 18,500 Tether, valued at around $18,500, in July with a federal search warrant.

"Hello Sir/Ma'am, My name is Vishal Gautam," the request starts. "The funds which you have on hold that is a very big amount of money for me and my family, I request you to please release it from your custody. Thank You & Regards." The message says that Gautam lives in India and as well as investing in cryptocurrency, he is a "full-time Health Insurance" worker. "In the month of July 2023 suddenly my crypto from Binance got disappeared, I don't know how it happened but then I got to know that the FBI has put hold on my assets," the message continues. "I am not into something illegal and never will be, I will not do any such thing that can harm your country or your people in any manner." U.S. authorities, meanwhile, allege that the seized cash is connected to a fraud scheme that targeted a senior citizen in Knoxville, Iowa. In February, this victim opened an email on her iPad that claimed it had been compromised, and that she needed to contact the sender for assistance, according to the court record.

An anonymous reader quotes a report from TechCrunch: Michigan-based McLaren Health Care has confirmed that the sensitive personal and health information of 2.2 million patients was compromised during a cyberattack earlier this year. A ransomware gang later took credit for the cyberattack. In a new data breach notice filed with Maine's attorney general, McLaren said hackers were in its systems for three weeks during July 28 through August 23 before the healthcare company noticed a week later on August 31. McLaren said the hackers accessed patient names, their date of birth and Social Security number, and a wealth of medical information, including billing, claims and diagnosis information, prescription and medication details, and information relating to diagnostic results and treatments. Medicare and Medicaid patient information was also taken.

McLaren is a healthcare provider with 13 hospitals across Michigan and about 28,000 total employees. McLaren, whose website touts its cost efficiency measures, made over $6 billion in revenue in 2022. News of the incident broke in October when the Alphv ransomware gang (also known as BlackCat) claimed responsibility for the cyberattack, claiming it took millions of patients' personal information. Days after the cyberattack was disclosed, Michigan attorney general Dana Nessel warned state residents that the breach "could affect large numbers of patients." TechCrunch has seen several screenshots posted by the ransomware gang on its dark web leak site showing access to the company's password manager, internal financial statements, some employee information, and spreadsheets of patient-related personal and health information, including names, addresses, phone numbers, Social Security numbers, and diagnostic information. Alphv/BlackCat claimed in its post that the gang had been in contact with a McLaren representative, without providing evidence of the claim.

New York regulators Monday plan to issue cybersecurity regulations for hospitals, after a series of attacks crippled operations at medical facilities. From a report: Under draft rules reviewed by The Wall Street Journal, New York will require general hospitals to develop and test incident response plans, assess their cybersecurity risks and install security technologies such as multifactor authentication. Hospitals must also develop secure software design practices for in-house applications, and processes for testing the security of software from vendors. Hacking "is a threat to every hospital, and my firm belief is if we protect the hospital, we're protecting the patients," said James McDonald, health commissioner for New York state.

Healthcare facilities are popular targets for cybercriminals, particularly ransomware operators hoping for quick ransom payments from administrators worried about risks to patients if technology goes down. Hospitals also hold large amounts of sensitive personal information on their staff and patients, including health and financial data. In August, the largest healthcare accreditation body in the U.S. issued cybersecurity guidelines calling for hospitals to prepare for cyberattacks that could take down critical systems for a month or longer -- measures that will require significant investment. Hospitals need to put in place tools and processes that anticipate technology critical for life and safety could be down, and find alternative ways to work without those systems, the nonprofit Joint Commission said.

Cells have a protein receptor that will cause that cell to die — in theory. Unfortunately, "Previous efforts to target this receptor have been unsuccessful," says Jogender Tushir-Singh, an associate professor in the Department of Medical Microbiology and Immunology at the University of California, Davis.

But he's now led a team of researchers at the university's Comprehensive Cancer Center that's identified a receptor-activating protein section. And more importantly, "now that we've identified this epitope, there could be a therapeutic path forward" for targeting that receptor... in tumors. The findings were published Oct. 14 in the Nature journal Cell Death & Differentiation... Death receptors do precisely what their name implies — when targeted, they trigger programmed cell death of tumor cells. They offer a potential workaround that could simultaneously kill tumor cells and pave the way for more effective immunotherapies and CAR T-cell therapy...

Tushir-Singh and his colleagues knew they might be able to target cancer cells selectively if they found the right epitope. Having identified this specific epitope, he and other researchers can now design a new class of antibodies to selectively bind to and activate Fas to potentially destroy tumor cells specifically.
Singh says their research "sets the stage" to develop antibodies that selectively kill tumor cells.

This week the Verge's podcast Decoder interviewed former U.S. president Barack Obama for a discussion on "AI, free speech, and the future of the internet."

Obama warns that future copyright questions are just part of a larger issue. "If AI turns out to be as pervasive and as powerful as it's proponents expect — and I have to say the more I look into it, I think it is going to be that disruptive — we are going to have to think about not just intellectual property; we are going to have to think about jobs and the economy differently."

Specific issues may include the length of the work week and the fact that health insurance coverage is currently tied to employment — but it goes far beyond that: The broader question is going to be what happens when 10% of existing jobs now definitively can be done by some large language model or other variant of AI? And are we going to have to reexamine how we educate our kids and what jobs are going to be available...?

The truth of the matter is that during my presidency, there was I think a little bit of naivete, where people would say, you know, "The answer to lifting people out of poverty and making sure they have high enough wages is we're going to retrain them and we're going to educate them, and they should all become coders, because that's the future." Well, if AI's coding better than all but the very best coders? If ChatGPT can generate a research memo better than the third-, fourth-year associate — maybe not the partner, who's got a particular expertise or judgment? — now what are you telling young people coming up?
While Obama believes in the transformative potential of AI, "we have to be maybe a little more intentional about how our democracies interact with what is primarily being generated out of the private sector. What rules of the road are we setting up, and how can we make sure that we maximize the good and maybe minimize some of the bad?"

AI's impact will be a global problem, Obama believes, which may require "cross-border frameworks and standards and norms". (He expressed a hope that governments can educate the public on the idea that AI is "a tool, not a buddy".) During the 44-minute interview Obama predicted AI will ultimately force a "much more robust" public conversation about rules needed for social media — and that at least some of that pressure could come from how consumers interact with companies. (Obama also argues there will still be a market for products that don't just show you what you want to see.)

"One of Obama's worries is that the government needs insight and expertise to properly regulate AI," writes the Verge's editor-in-chief in an article about the interview, "and you'll hear him make a pitch for why people with that expertise should take a tour of duty in the government to make sure we get these things right." You'll hear me get excited about a case called Red Lion Broadcasting v. FCC, a 1969 Supreme Court decision that said the government could impose something called the Fairness Doctrine on radio and television broadcasters because the public owns the airwaves and can thus impose requirements on how they're used. There's no similar framework for cable TV or the internet, which don't use public airwaves, and that makes them much harder, if not impossible, to regulate. Obama says he disagrees with the idea that social networks are something called "common carriers" that have to distribute all information equally.
Obama also applauded last month's newly-issued Executive Order from the White House, a hundred-page document which Obama calls important as "the beginning of building out a framework." We don't know all the problems that are going to arise out of this. We don't know all the promising potential of AI, but we're starting to put together the foundations for what we hope will be a smart framework for dealing with it... In talking to the companies themselves, they will acknowledge that their safety protocols and their testing regimens may not be where they need to be yet. I think it's entirely appropriate for us to plant a flag and say, "All right, frontier companies, you need to disclose what your safety protocols are to make sure that we don't have rogue programs going off and hacking into our financial system," for example. Tell us what tests you're using. Make sure that we have some independent verification that right now this stuff is working.

But that framework can't be a fixed framework. These models are developing so quickly that oversight and any regulatory framework is going to have to be flexible, and it's going to have to be nimble.

A new book argues lockdowns during the pandemic were "a failure." But in response CNN published an opinion piece disagreeing — written by physician/infectious disease expert Kent Sepkowitz from the Memorial Sloan Kettering Cancer Center in New York — who argues "You bet it was worth it." [Authors Joe Nocera and Bethany McLean] consider the lockdown a single activity stretched across the entire pandemic; in contrast, I would distinguish the initial lockdown, which was crucial, from the off-and-on lockdowns as therapies, vaccines and overall care improved. There is an argument to be made that these were not anywhere near as effective... One only had to work in health care in New York City to see the difference between early 2020, when the explosion of cases overwhelmed the city, versus later in 2020 when an effective therapy had been identified, supplies and diagnostic testing had been greatly improved (though still completely inadequate) and the makeshift ICUs and emergency rooms had been set in place. It was still a nightmare to be sure, but it was a vastly more organized nightmare.

The "short-term benefits" at the start of the pandemic are simple to characterize: Every infection that was delayed due to the lockdowns was a day to the good, a day closer to the release of the mRNA vaccines in December 2020, a less-hectic day for the health care workers, a day for clinical trials to mature. Therefore, the authors' statement that lockdowns "were a mistake that should not be repeated" because they had no "purpose other than keeping hospitals from being overrun in the short-term" is to me a fundamental misunderstanding of the day-to-day work that was being done. Most disturbing to me about this assessment and the others that have come along are the minimal mention of the death and debility the infection caused. A reminder for those who have forgotten just how brutal the pandemic was: Worldwide there have been 7 million deaths. In the U.S., there have been more than a million deaths, millions have some post-infection debility and many health care workers remain profoundly demoralized. [By these figures the U.S., with 4.2% of the world's population, had 14% of Covid fatalities.]

In this context, many of the outcomes of concern listed by Nocera and McLean — suicidal thoughts in teens, alcoholism and drug use increases, violence — are as easily explained by this staggering death toll as by the cabin fever brought on by lockdowns. Once again: About 1 out of every 350 Americans died in the Covid-19 pandemic. Another way to consider the impact of so many deaths is examination of life expectancy. Of note, life expectancy in the U.S. fell in 2020 (1.8 years) and 2021 (0.6 years), the sharpest drop since the 1920s; per the US Centers for Disease Control and Prevention, 74% of the drop was attributed to Covid-19... To fall more than two years so precipitously requires the deaths of many in their 30s and 40s and 50s, as occurred with the first year of the pandemic.

An anonymous reader quotes a report from The Record: One of the nation's largest private radiology companies agreed to pay a $450,000 fine after a 2021 ransomware attack led to the exposure of sensitive information from nearly 200,000 patients. In an agreement announced on Wednesday, New York Attorney General Letitia James said US Radiology failed to remediate a vulnerability announced by security company SonicWall in January 2021. US Radiology used the company's firewall to protect its network and provide managed services for many of its partner companies, including the Windsong Radiology Group, which has six facilities across Western New York.

The vulnerability highlighted by the attorney general -- CVE-2021-20016 -- was used by ransomware gangs in several attacks. US Radiology was unable to install the firmware patch for the zero-day because its SonicWall hardware was at an end-of-life stage and was no longer supported. The company planned to replace the hardware in July 2021, but the project was delayed "due to competing priorities and resource restraints." The vulnerability was never addressed, and the company was attacked by an unnamed ransomware gang on December 8, 2021.

An investigation determined that the hacker was able to gain access to files that included the names, dates of birth, patient IDs, dates of service, provider names, types of radiology exams, diagnoses and/or health insurance ID numbers of 198,260 patients. The data exposed during the incident also included driver's license numbers, passport numbers, and Social Security numbers for 82,478 New Yorkers. [...] In addition to the $450,000 penalty, the company will have to upgrade its IT network, hire someone to manage its data security program, encrypt all sensitive patient information and develop a penetration testing program. The company will have to delete patient data "when there is no reasonable business purpose to retain it" and submit compliance reports to the state for two years. "When patients visit a medical facility, they deserve confidence in knowing that their personal information will not be compromised when they are receiving care," said Attorney General James. "US Radiology failed to protect New Yorkers' data and was vulnerable to attack because of outdated equipment. In the face of increasing cyberattacks and more sophisticated scams to steal private data, I urge all companies to make necessary upgrades and security fixes to their computer hardware and systems."

An anonymous reader quotes a report from Scientific American: This week doctors announced they had completed the first successful transplant of a partial face and an entire eye. In May at NYU Langone Health in New York City, the surgery was performed on a 46-year-old man who had suffered severe electrical burns to his face, left eye and left arm. He does not yet have vision in the transplanted eye and may never regain it there, but early evidence suggests the eye itself is healthy and may be capable of transmitting neurological signals to the brain. The feat opens up the possibility of restoring the appearance -- and maybe even sight -- of people who have been disfigured or blinded by injuries. Researchers caution there are many technical hurdles before such a procedure can effectively treat vision loss, however.

"I think it's an important proof of principle," says Jeffrey Goldberg, a professor and chair of ophthalmology at the Byers Eye Institute at Stanford University, who was not involved in the surgery but has been part of a team working toward whole-eye transplants in humans. "I think it points to the opportunity and importance that we really stand on the verge of being able to [achieve] eye transplants and vision restoration for blind patients more broadly."But he cautions that the main obstacle is achieving regeneration of the optic nerve, which carries visual signals from the retina to the brain; this step has not yet been successfully demonstrated in humans.

Scientists have been working toward whole-eye transplantation for many years. "This has been, I would say, science fiction for a long time," says Jose-Alain Sahel, a professor and chair of the department of ophthalmology at the University of Pittsburgh School of Medicine, who has been working toward such transplants with Goldberg and others. Progress in surgical techniques and nerve regeneration have made this goal seem more attainable. [...] "The fact that this surgery was successful is wonderful news," Sahel says. He cautions that surgery is only a small part of the issues that need to be addressed in order to restore eye function, however. These include making sure the immune system doesn't reject the donor eye, which is a challenge with any type of transplant. Then the corneal nerve -- which carries sensory signals from the transparent part of the eye -- must be reconnected. Yet the most complex part is regenerating the optic nerve. In order to do so, surgeons have to coax the nerve fibers to grow to the right place, which Sahel says could take months or even years. And complete optic nerve regeneration has not yet been successfully achieved in humans or other mammals.

An anonymous reader quotes a report from TechCrunch: The government of Maine has confirmed over a million state residents had personal information stolen in a data breach earlier this year by a Russia-linked ransomware gang. In a statement published Thursday, the Maine government said hackers exploited a vulnerability in its MOVEit file-transfer system, which stored sensitive data on state residents. The hackers used the vulnerability to access and download files belonging to certain state agencies between May 28 and May 29, the statement read. The Maine government said it was disclosing the incident and notifying affected residents as its assessment of the impacted files "was recently completed."

Maine said that the stolen information may include a person's name, date of birth, Social Security number, driver's license and other state or taxpayer identification numbers. Some individuals had medical and health insurance information taken. The statement said the state holds information about residents "for various reasons, such as residency, employment, or interaction with a state agency," and that the data it holds varies by person. According to the state's breakdown of which agencies are affected, more than half of the stolen data relates to Maine's Department of Health and Human Services, with up to about a third of the data affecting the Maine's Department of Education. The remaining data affects various other agencies, including Maine's Bureau of Motor Vehicles and Maine's Department of Corrections, though the government notes that the breakdown of information is subject to change. More than 1.3 million people live in the state of Maine, according to the U.S. Census Bureau.

Long-time Slashdot reader Alain Williams writes: Apple co-founder Steve Wozniak is in the hospital in Mexico, according to multiple reports.

It is not currently clear what the cause is. The 73-year-old was in Mexico City attending the World Business Forum (WBF), a business conference. [According to TMZ, Wozniak finished his speech but then told his wife he was "feeling strange." She reportedly insisted he go to the hospital.] An unnamed source from the WBF said that Mr Wozniak fainted on Wednesday at the event [minutes before his participation], according to CNN. TMZ reports that Wozniak was hospitalized after "suffering what appears to be vertigo." Mexican media outlets were reporting that it was due to a possible stroke.

An anonymous reader quotes a report from the Financial Times: Amazon Prime members will be able to access US healthcare provider One Medical's suite of benefits, for a fee, as the ecommerce company looks to expand its presence in the $4 trillion American healthcare industry. Prime members in the US who opt in will have access to unlimited, on-demand virtual healthcare via One Medical, the subscription-based group that Amazon acquired last year for $3.9 billion. They will also be able to schedule in-person appointments that they will either pay for themselves or that will be covered by insurance.

The addition to Amazon's flagship Prime membership program comes as the company looks to "stack" healthcare services together and broaden its reach in the sector, which would be "big for us if we do a good job," said Neil Lindsay, senior vice-president of Amazon Health. The subscription will cost Amazon Prime members $9 per month or $99 per year, compared with the standard One Medical subscription fee of $199 per year. That will come on top of the $139 per year, or $14.99 a month, price for a Prime subscription.

The move is Amazon's latest effort to leverage its loyal base of Prime members and become a big player in the healthcare industry. In January, following its 2018 acquisition of mail-order pharmacy PillPack for about $1 billion, Amazon launched RxPass, which allows Prime members to order an unlimited amount of some unbranded prescription medications for $5 a month. It has also rolled out a "Clinic" telehealth service that connects patients with clinicians and a broader mail-order pharmacy service.

An anonymous reader quotes a report from The Guardian: Marc, 63, from Bordeaux, France, was diagnosed with the degenerative disease more than 20 years ago and had developed severe mobility problems, including balance impairments and freezing of gait. After receiving the implant, which aims to restore normal signaling to the leg muscles from the spine, he has been able to walk more normally and regained his independence. "I practically could not walk any more without falling frequently, several times a day. In some situations, such as entering a lift, I'd trample on the spot, as though I was frozen there, you might say," he said. "Right now, I'm not even afraid of the stairs any more. Every Sunday I go to the lake, and I walk around 6 kilometers [3.7 miles]. It's incredible."

The implant is yet to be tested in a full clinical trial. But the Swiss team, who have a longstanding program to develop brain-machine interfaces to overcome paralysis, hope that their technology could offer an entirely new approach to treating movement deficits in those with Parkinson's disease. "It is impressive to see how by electrically stimulating the spinal cord in a targeted manner, in the same way as we have done with paraplegic patients, we can correct walking disorders caused by Parkinson's disease," said Jocelyne Bloch, neurosurgeon and professor at the CHUV Lausanne University hospital, who co-led the work.

First, the team developed a personalized anatomical map of Marc's spinal cord that identified the precise locations that were involved in signaling to the leg to move. Electrodes were then implanted at these locations, allowing stimulation to be delivered directly into the spine. The patient wears a movement sensor on each leg and when walking is initiated the implant automatically switches on and begins delivering pulses of stimulation to the spinal neurons. The aim is to correct abnormal signals that are sent from the brain, down the spine, to the legs in order to restore normal movement. "At no point is [the patient] controlled by the machine," said Prof Eduardo Martin Moraud, of Lausanne University hospital. "It's just enhancing his capacity to walk." The study, published in Nature Medicine, found that the implant improved walking and balance deficits and when Marc's walking was analyzed it more closely resembled that of healthy controls than that of other Parkinson's patients. Marc also reported significant improvements in his quality of life.

Jacob Knutson reports via Axios: Sensitive, highly detailed personal data for thousands of active-duty and veteran U.S. military members can be purchased for as little as one cent per name through data broker websites, according to a new study (PDF) published on Monday by Duke University researchers. [...] The data about military personnel purchased as part of the study included full names, physical and email addresses, health and financial information and details about their ethnicity, religious practices and political affiliation. In some cases, the information also included whether the person owned or rented a home, was married or had children. The children's ages and sexes were accessible, too.

The researchers bought data on up to around 45,000 military personnel for between $0.12 to $0.32 per record. They also bought data belonging to 5,000 friends and family members of military personnel. Larger data purchases of over 1.5 million service members were available for as little as $0.01 per record from at least one broker the researchers contacted. The researchers called on Congress to pass a comprehensive privacy law and for regulatory agencies like the Federal Trade Commission to develop rules to govern military personnel data purchases.

An anonymous reader quotes a report from 404 Media: Attendees at a conference for Bored Ape NFT owners are reporting waking up in the middle of the night following laser and blacklight-heavy performances with extreme eye pain and vision loss. Yuga Labs, the parent company of Bored Ape Yacht Club, hosted ApeFest in Hong Kong from November 3-5. The event was open to holders of Bored Ape NFTs, a crypto project that peaked in 2021 and recently crashed to a two-year low, costing many investors thousands of dollars.

"I woke up at 04:00 and couldn't see anymore. Had so much pain and my whole skin is burned. Needed to go to the hospital," one attendee posted on the last day of the event. "The doctor told me the uv of the lightning of the stage did it. It has the same effect as sunlight. Still can not see normally.." "Same here for me and +1. I had eyeglasses, so was a bit spared, but skin is burned and +1 had the same degree of issues with eyes," someone replied. "The toilets may have been great, but what happened to our eyeballs last night at #ApeFest?" another attendee wrote, as a follow-up to a photo of him sitting on a toilet with his pants around his ankles in a room bathed in intense blacklights. "Been to lots of concerts, festivals, Burning Man, and never have I ever experienced fucked eyes like this."

Even as they woke up in the middle of the night with blinding eye pain, some attendees still praised the organizers for the event. "Thanks for great apefest logistiscs guys @yugalabs & @BoredApeYC. Incredible event and met plenty of amazing people," one wrote. "Still, as dozens of others, I've almost lost sight this night." They suggested others get their eyes checked like they did, and said their eyes were burned by UV. "To the organisers: For the communication & awareness reasons, it would be fair to put together an official statement with recommendations what to do, as dozens of people you care about were exposed to serious health hazards and lots of suffering," they continued. "You're good guys so it should be easy for you to recognise the seriousness of it." Photos and videos from the event show crowds of young men doing some of the worst moshing I've ever seen to performances and conference rooms soaked in blacklight and lasers. Where in the venue the damage was done is still unclear. Bored Ape Yacht Club acknowledged the issue in a post early Monday morning: "Apes, we are aware of the eye-related issues that affected some of the attendees of ApeFest and have been proactively reaching out to individuals since yesterday to try and find the potential root causes," the official account tweeted. "Based on our estimates, we believe that much less than 1% of those attending and working the event had these symptoms. While nearly everyone has indicated their symptoms have improved, we encourage anybody who feels them to seek medical attention just in case."