The FDA plans to use AI to "radically increase efficiency" in deciding whether to approve new drugs and devices, drawing on lessons from Operation Warp Speed to reduce review times to weeks. The plan was laid out in an article published Tuesday in JAMA. The New York Times reports: Another initiative involves a review of chemicals and other "concerning ingredients" that appear in U.S. food but not in the food of other developed nations. And officials want to speed up the final stages of making a drug or medical device approval decision to mere weeks, citing the success of Operation Warp Speed during the Covid pandemic when workers raced to curb a spiraling death count. [...]

Last week, the agency introduced Elsa, an artificial intelligence large-language model similar to ChatGPT. The FDA said it could be used to prioritize which food or drug facilities to inspect, to describe side effects in drug safety summaries and to perform other basic product-review tasks. The FDA officials wrote that A.I. held the promise to "radically increase efficiency" in examining as many as 500,000 pages submitted for approval decisions.

Current and former health officials said the A.I. tool was helpful but far from transformative. For one, the model limits the number of characters that can be reviewed, meaning it is unable to do some rote data analysis tasks. Its results must be checked carefully, so far saving little time. Staff members said that the model was hallucinating, or producing false information. Employees can ask the Elsa model to summarize text or act as an expert in a particular field of medicine.

China's southernmost province of Hainan is piloting a programme to grant select corporate users broad access to the global internet, a rare move in a country known for having some of the world's most restrictive online censorship, as the island seeks to transform itself into a global free-trade port. From a report: Employees of companies registered and operating in Hainan can apply for the "Global Connect" mobile service through the Hainan International Data Comprehensive Service Centre (HIDCSC), according to the agency, which is overseen by the state-run Hainan Big Data Development Centre.

The programme allows eligible users to bypass the so-called Great Firewall, which blocks access to many of the world's most-visited websites, such as Google and Wikipedia. Applicants must be on a 5G plan with one of the country's three major state-backed carriers -- China Mobile, China Unicom or China Telecom -- and submit their employer's information, including the company's Unified Social Credit Code, for approval. The process can take up to five months, HIDCSC staff said.

Major Hollywood studios are extensively using AI tools while avoiding public disclosure, according to industry sources interviewed by New York Magazine. Nearly 100 AI studios now operate in Hollywood with every major studio reportedly experimenting with generative AI despite legal uncertainties surrounding copyright training data, the report said.

Lionsgate has partnered with AI company Runway to create a customized model trained on the studio's film archive, with executives planning to generate entire movie trailers from scripts before shooting begins. The collaboration allows the studio to potentially reduce production costs from $100 million to $50 million for certain projects.

Widespread usage of the new technology is often happening through unofficial channels. Workers are reporting pressure to use AI tools without formal studio approval, then "launder" the AI-generated content through human artists to obscure its origins.

Anne Wojcicki has asked a U.S. judge to reopen the auction for 23andMe, claiming she has backing from a $400+ billion Fortune 500 company. Reuters reports: South San Francisco, California-based 23andMe filed for bankruptcy in March, seeking to sell its business at auction after a decline in consumer demand and a 2023 data breach that exposed sensitive genetic and personal information of millions of customers. Last month, Regeneron Pharmaceuticals agreed to buy the firm for $256 million, topping a $146 million bid from Wojcicki and TTAM Research Institute, which was founded by Wojcicki and describes itself as a California non-profit public benefit corporation.

In a filing dated May 31, Wojcicki claimed that 23andMe's debtors had attempted to tilt the sales process away from TTAM and in favor of Regeneron. TTAM and Wojcicki said in the filing that 23andMe's financial and legal advisers unfairly capped their maximum bid at $250 million due to misplaced concerns about TTAM's "financial wherewithal." The plaintiffs said the auction was prematurely concluded before they had the opportunity to submit a bid that would have exceeded $280 million.

The company's debtors said the auction results came after an extensive and careful consideration by a four-member special committee of independent directors, according to the filing. According to another filing, 23andMe is seeking court approval to let Wojcicki and Regeneron submit final proposals by June 12. 23andMe is also seeking a $10 million breakup fee for Regeneron if Wojcicki's bid is ultimately accepted.

Laurene Powell Jobs has publicly endorsed the secretive AI hardware device being developed by Jony Ive and OpenAI, expressing admiration for his design process and investing in his ventures. Ive says the project is an attempt to address the unintended harms of past tech like the iPhone, and Powell Jobs stands to benefit financially if the device succeeds. The Verge reports: In a new interview published by The Financial Times, the two reminisce about Jony Ive's time working at Apple alongside Powell Jobs' late husband, Steve, and trying to make up for the "unintentional" harms associated with those efforts. [...] Powell Jobs, who has remained close friends with Ive since Steve Jobs passed in 2011, echoes his concerns, saying that "there are dark uses for certain types of technology," even if it "wasn't designed to have that result." Powell Jobs has invested in both Ive's LoveFrom design and io hardware startups following his departure from Apple. Ive notes that "there wouldn't be LoveFrom" if not for her involvement. Ive's io company is being purchased by OpenAI for almost $6.5 billion, and with her investment, Powell Jobs stands to gain if the secretive gadget proves anywhere near as successful as the iPhone.

The pair gives away no extra details about the device that Ive is building with OpenAI, but Powell Jobs is expecting big things. She says she has watched "in real time how ideas go from a thought to some words, to some drawings, to some stories, and then to prototypes, and then a different type of prototype," Powell Jobs said. "And then something that you think: I can't imagine that getting any better. Then seeing the next version, which is even better. Just watching something brand new be manifested, it's a wondrous thing to behold."

An anonymous reader quotes a report from Ars Technica: It has become a common refrain during Google's antitrust saga: What happened to "don't be evil?" Google's unofficial motto has haunted it as it has grown ever larger, but a shareholder lawsuit sought to rein in some of the company's excesses. And it might be working. The plaintiffs in the case have reached a settlement with Google parent company Alphabet, which will spend a boatload of cash on "comprehensive" reforms. The goal is to steer Google away from the kind of anticompetitive practices that got it in hot water.

Under the terms of the settlement, obtained by Bloomberg Law, Alphabet will spend $500 million over the next 10 years on systematic reforms. The company will have to form a board-level committee devoted to overseeing the company's regulatory compliance and antitrust risk, a rarity for US firms. This group will report directly to CEO Sundar Pichai. There will also be reforms at other levels of the company that allow employees to identify potential legal pitfalls before they affect the company. Google has also agreed to preserve communications. Google's propensity to use auto-deleting chats drew condemnation from several judges overseeing its antitrust cases. The agreement still needs approval from US District Judge Rita Lin in San Francisco, but that's mainly a formality at this point. Naturally, Alphabet does not admit to any wrongdoing under the terms of the settlement, but it may have to pay tens of millions in legal fees on top of the promised $500 million investment.

An anonymous reader shares a report: Without seeking approval of the San Francisco Board of Education, Superintendent of Schools Maria Su plans to unveil a new Grading for Equity plan on Tuesday that will go into effect this fall at 14 high schools and cover over 10,000 students. The school district is already negotiating with an outside consultant to train teachers in August in a system that awards a passing C grade to as low as a score of 41 on a 100-point exam.

Were it not for an intrepid school board member, the drastic change in grading with implications for college admissions and career readiness would have gone unnoticed and unexplained. It is buried in a three-word phrase on the last page of a PowerPoint presentation embedded in the school board meeting's 25-page agenda. The plan comes during the last week of the spring semester while parents are assessing the impact of over $100 million in budget reductions and deciding whether to remain in the public schools this fall. While the school district acknowledges that parent aversion to this grading approach is typically high and understands the need for "vigilant communication," outreach to parents has been minimal and may be nonexistent. The school district's Office of Equity homepage does not mention it and a page containing the SFUSD definition of equity has not been updated in almost three years.

Grading for Equity eliminates homework or weekly tests from being counted in a student's final semester grade. All that matters is how the student scores on a final examination, which can be taken multiple times. Students can be late turning in an assignment or showing up to class or not showing up at all without it affecting their academic grade. Currently, a student needs a 90 for an A and at least 61 for a D. Under the San Leandro Unified School District's grading for equity system touted by the San Francisco Unified School District and its consultant, a student with a score as low as 80 can attain an A and as low as 21 can pass with a D.

Texas Governor Greg Abbott signed an online child safety bill, bucking a lobbying push from big tech companies that included a personal phone call from from Apple CEO Tim Cook. From a report: The measure requires app stores to verify users' ages and secure parental approval before minors can download most apps or make in-app purchases. The bill drew fire from app store operators such as Google and Apple, which has argued that the legislation threatens the privacy of all users.

The bill was a big enough priority for Apple that Cook called Abbott to emphasize the company's opposition to it, said a person familiar with their discussion, which was first reported by the Wall Street Journal.

AT&T is buying CenturyLink's consumer fiber broadband division for $5.75 billion, "giving the internet provider another 1.1 million fiber customers in 11 states," reports Ars Technica. "The all-cash deal is expected to close during the first half of 2026 assuming the companies obtain regulatory approval. AT&T will gain new customers in Arizona, Colorado, Florida, Idaho, Iowa, Minnesota, Nebraska, Nevada, Oregon, Utah, and Washington." From the report: The deal will give AT&T room to grow its user base by more than the 1.1 million existing CenturyLink customers, as AT&T said the network areas being sold include over 4 million fiber-enabled locations. [...] The company, previously called CenturyLink, is officially named Lumen now but still uses the CenturyLink brand name for home Internet service. AT&T, which has 9.6 million (PDF) fiber customers and 14.1 million broadband customers overall, said the infrastructure it is purchasing will help it expand fiber construction to new locations as well.

The deal is also notable for what it doesn't include: Lumen's enterprise fiber customers and the old copper DSL lines that were never upgraded to fiber. [...] The deal seems unlikely to improve matters for CenturyLink copper users. [...] Lumen will retain the CenturyLink consumer copper broadband and voice services, but selling the consumer fiber business makes it clear that the telco isn't focused on residential customers. Lumen said that offloading consumer fiber lines will help sharpen its focus on selling services to large businesses. The company is maintaining its business fiber lines. [Ars notes that there are still nearly 1.4 million CenturyLink copper internet customers that will likely see service continue to degrade under Lumen's ownership.] "The transaction will enable AT&T to significantly expand access to AT&T Fiber in major metro areas like Denver, Las Vegas, Minneapolis-St. Paul, Orlando, Phoenix, Portland, Salt Lake City and Seattle, as well as additional geographies," AT&T said.

"AT&T will gain access to Lumen's substantial fiber construction capabilities within its incumbent local exchange carrier (ILEC) footprint and plans to accelerate the pace at which fiber is being built in these territories," AT&T said. "AT&T now expects to reach approximately 60 million total fiber locations by the end of 2030 -- "roughly doubling where AT&T Fiber is available today."

SAG-AFTRA has filed a labor complaint against Fortnite developer Epic Games, alleging the game improperly used AI to replicate James Earl Jones' Darth Vader voice without bargaining with the union, despite the estate's approval. Gizmodo reports: The union has now filed an unfair labor practice charge (link to the PDF is on the SAG-AFTRA website) that calls out "Fortnite's signatory company, Llama Productions" for "[replacing] the work of human performers with AI technology" without "providing any notice of their intent to do this and without bargaining with us over appropriate terms."

The union notes that it's not against the general idea here: "We celebrate the right of our members and their estates to control the use of their digital replicas and welcome the use of new technologies to allow new generations to share in the enjoyment of those legacies and renowned roles." The problem is that the AI being used here makes human voice actors obsolete, and "we must protect our right to bargain terms and conditions around uses of voice that replace the work of our members, including those who previously did the work of matching Darth Vader's iconic rhythm and tone in video games."

So far there's been no response from Epic Games on the filing. The Hollywood Reporter notes that despite the SAG-AFTRA's still-ongoing Interactive Media Agreement strike, which has been stuck for months on negotiating "AI protections for voice actors in video games," actors can actually work on Fortnite without violating the strike, since the game falls under an exception for titles that were in production before August 2023.

Regeneron Pharmaceuticals is acquiring most of 23andMe's assets for $256 million. The sale includes 23andMe's Personal Genome Service, Total Health and Research Services business lines. What's not included is 23andMe's telehealth unit, Lemonaid Health, which the company acquired for around $400 million in 2021. It'll be shut down, but all staffers will remain employed. CNBC reports: The deal is still subject to approval by the U.S. Bankruptcy Court for the Eastern District of Missouri. Pending approval, it's expected to close in the third quarter of this year, according to the release. In its bankruptcy proceedings, 23andMe required all bidders to comply with its privacy policies, and a court-appointed, independent "Consumer Privacy Ombudsman" will assess the deal, the companies said.

Several lawmakers and officials, including the Federal Trade Commission, had expressed concerns about the safety of consumers' genetic data through 23andMe's sale process. The privacy ombudsman will present a report on the acquisition to the court by June 10. "We are pleased to have reached a transaction that maximizes the value of the business and enables the mission of 23andMe to live on, while maintaining critical protections around customer privacy, choice and consent with respect to their genetic data," Mark Jensen, 23andMe's board chair, said in a statement. "At its peak, 23andMe was valued at around $6 billion," notes the report.

While Amazon won FAA approval to fly beyond an operators' visual line of sight, "the program remains a work in progress," reports Bloomberg: A pair of Amazon.com Inc. package delivery drones were flying through a light rain in mid-December when, within minutes of one another, they both committed robot suicide... [S]ome 217 feet (66 meters) in the air [at a drone testing facility], the aircraft cut power to its six propellers, fell to the ground and was destroyed. Four minutes later and 183 feet over the taxiway, a second Prime Air drone did the same thing.

Not long after the incidents, Amazon paused its experimental drone flights to tweak the aircraft software but said the crashes weren't the "primary reason" for halting the program. Now, five months after the twin crashes, a more detailed explanation of what happened is starting to emerge. Faulty readings from lidar sensors made the drones think they had landed, prompting the software to shut down the propellers, according to National Transportation Safety Board documents reviewed by Bloomberg. The sensors failed after a software update made them more susceptible to being confused by rain, the NTSB said.
Amazon also removed a backup sensor present that had been present on earlier iterations, according to the article — though an Amazon spokesperson said the company had found ways to replicate the removed sensors.

But Bloomberg notes Amazon's drone efforts has faced "technical challenges and crashes, including one in 2021 that set a field ablaze at the company's testing facility in Pendleton, Oregon." Deliveries are currently limited to College Station, Texas, and greater Phoenix, with plans to expand to Kansas City, Missouri, the Dallas area and San Antonio, as well as the UK and Italy. Starting with a craft that looked like a hobbyist drone — and was vulnerable to even modest gusts of wind — Amazon went through dozens of designs to toughen the vehicle and ultimately make it capable of carting about 5 pounds, giving it the capability to transport items typically ordered from its warehouses. Engineers settled on a six-propeller design that takes off vertically before cruising like a plane. The first model to make regular customer deliveries, the MK27, was succeeded last year by the MK30, which flies at about 67 miles an hour and can deliver packages up to 7.5 miles from its launch point. The craft takes off, flies and lands autonomously.

An anonymous reader quotes a report from the Associated Press: U.S. health officials on Friday endorsed the first blood test that can help diagnose Alzheimer's and identify patients who may benefit from drugs that can modestly slow the memory-destroying disease. The test can aid doctors in determining whether a patient's memory problems are due to Alzheimer's or a number of other medical conditions that can cause cognitive difficulties. The Food and Drug Administration cleared it for patients 55 and older who are showing early signs of the disease.

The new test, from Fujirebio Diagnostics, Inc., identifies a sticky brain plaque, known as beta-amyloid, that is a key marker for Alzheimer's. Previously, the only FDA-approved methods for detecting amyloid were invasive tests of spinal fluid or expensive PET scans. The lower costs and convenience of a blood test could also help expand use of two new drugs, Leqembi and Kisunla, which have been shown to slightly slow the progression of Alzheimer's by clearing amyloid from the brain. Doctors are required to test patients for the plaque before prescribing the drugs, which require regular IV infusions. [...]

A number of specialty hospitals and laboratories have already developed their own in-house tests for amyloid in recent years. But those tests aren't reviewed by the FDA and generally aren't covered by insurance. Doctors have also had little data to judge which tests are reliable and accurate, leading to an unregulated marketplace that some have called a "wild west." Several larger diagnostic and drug companies are also developing their own tests for FDA approval, including Roche, Eli Lilly and C2N Diagnostics. The tests can only be ordered by a doctor and aren't intended for people who don't yet have any symptoms.

The Federal Communications Commission has approved Verizon's $9.6 billion acquisition of Frontier Communications, valuing the Dallas-based company at $20 billion including debt. The approval comes after Verizon agreed to scale back diversity initiatives to comply with Trump administration policies.

FCC Chairman Brendan Carr, who previously threatened to block mergers over DEI practices, praised the deal for its potential to "unleash billions in new infrastructure builds" and "accelerate the transition away from old, copper line networks to modern, high-speed ones." The acquisition positions America's largest phone carrier to expand its high-speed internet footprint across Frontier's 25-state network. Verizon plans to deploy fiber to more than one million U.S. homes annually following the transaction.

schwit1 shares a report from Behind The Black: Almost immediately after India's government issued this week new tightened regulations for allowing private satellite constellations to sell their services in India, it also apparently completed negotiations with SpaceX to allow it to sell Starlink in India based on these rules. Business Today reports: "According to sources, the DoT [Department of Transportation] granted the LoI [Letter of Intent] after Starlink accepted 29 strict security conditions, including requirements for real-time terminal tracking, mandatory local data processing, legal interception capabilities, and localisation of at least 20% of its ground segment infrastructure within the first few years of operation.

Starlink's nod came amid heightened national security sensitivities, coinciding with India's pre-dawn Operation Sindoor strikes on terror camps across the border in response to the Pahalgam massacre. However, DoT officials clarified that the decision to approve Starlink was independent of these military developments." At the moment SpaceX's chief competitors, OneWeb and Amazon's Kuiper constellation, have not yet obtained the same permissions. This allows SpaceX to grab a large portion of the market share in India before either of these other companies.

English regulators have approved a new law firm that uses AI instead of lawyers to offer services for as little as $2.67, as the technology continues to disrupt industries from finance to accounting. From a report: Garfield AI, which was founded by a former London litigator and a quantum physicist, is an online tool that allows businesses and individuals such as tradespeople to chase debts owed to them at a substantially lower cost than the average lawyer's fees. Its AI assistant guides claimants through the small claims court process, including creating "polite chaser" letters for $2.67 and filing documents such as claim forms for $67, and can also produce arguments for claimants to use at trial.

AI models are increasingly encroaching on legally sensitive tasks in high-paying sectors such as law and finance, potentially undercutting fees in high-volume work. Garfield received approval from the Solicitors Regulation Authority, the legal regulator for England and Wales, in March, in a move the latter hailed as a "landmark moment" for the industry.

The FDA has approved gene-edited pigs for human consumption, potentially marking the first major commercial application of CRISPR technology in the food chain. Created by British company Genus, these pigs have had their DNA modified to remove the receptor that the porcine reproductive and respiratory syndrome (PRRS) virus uses to enter cells, rendering them immune to 99% of known virus variants.

PRRS causes losses of approximately $300 million annually in the US alone by killing piglets and spreading rapidly through factory farms. According to Matt Culbertson, chief operating officer of Genus subsidiary Pig Improvement Company, the gene-edited pork could reach US markets sometime next year. Before launching sales to pig farms, Genus must secure regulatory approval in key export markets including Mexico, Canada, Japan, and China.

Apple has updated its App Store Guidelines to comply with a court order from the Epic Games lawsuit, now allowing U.S. apps to include external payment links and buttons without needing special approval. "The App Review Guidelines have been updated for compliance with a United States court decision regarding buttons, external links, and other calls to action in apps. These changes affect apps distributed on the United States storefront of the App Store," Apple said in an email to developers on Thursday night. 9to5Mac reports: Here are the full changes to the App Store Guidelines with today's revisions:

3.1.1: Apps on the United States storefront are not prohibited from including buttons, external links, or other calls to action when allowing users to browse NFT collections owned by others.
3.1.1(a): On the United States storefront, there is no prohibition on an app including buttons, external links, or other calls to action, and no entitlement is required to do so.
3.1.3: The prohibition on encouraging users to use a purchasing method other than in-app purchase does not apply on the United States storefront.
3.1.3(a): The External Link Account entitlement is not required for apps on the United States storefront to include buttons, external links, or other calls to action. "We strongly disagree with the decision. We will comply with the court's order and we will appeal," Apple said in a statement to 9to5Mac yesterday.

Spotify, Patreon, Epic Games and others are already working to circumvent Apple's App Store fees.

Chad Anderson is the founder/managing partner of the early-stage VC Space Capital (and an investor in SpaceX, along with dozens of other space companies). Space Capital produces quarterly reports on the space economy, and he says today, unlike 2021, "the froth is gone. But so is the hype. What's left is a more grounded — and investable — space economy."

On Yahoo Finance he shares several of the report's insights — including the emergence of "investable opportunities across defense-oriented startups in space domain awareness, AI-driven command systems, and hardened infrastructure." The same geopolitical instability that's undermining public markets is driving national urgency around space resilience. China's simulated space "dogfights" prompted the US Department of Defense to double down on orbital supremacy, with the proposed "Golden Dome" missile shield potentially unleashing a new wave of federal spending...

Defense tech is on fire, but commercial location-based services and logistics are freezing over. Companies like Shield AI and Saronic raised monster rounds, while others are relying on bridge financings to stay afloat...

Q1 also saw a breakout quarter for geospatial artificial intelligence (GeoAI). Software developer Niantic launched a spatial computing platform. SkyWatch partnered with GIS software supplier Esri. Planet Labs collaborated with Anthropic. And Xona Space Systems inked a deal with Trimble to boost precision GPS. This is the next leg of the space economy, where massive volumes of satellite data is finally made useful through machine learning, semantic indexing, and real-time analytics.

Distribution-layer companies are doing more with less. They remain underfunded relative to infrastructure and applications but are quietly powering the most critical systems, such as resilient communications, battlefield networks, and edge-based geospatial analysis. Don't let the low round count fool you; innovation here is quietly outpacing capital.
The article includes several predictions, insights, and possible trends (going beyond the fact that defense spending "will carry the sector...")

• "AI's integration into space (across geospatial intelligence, satellite communications, and sensor fusion) is not a novelty. It's a competitive necessity."

• "Focusing solely on rockets and orbital assets misses where much of the innovation and disruption is occurring: the software-defined layers that sit atop the physical backbone..."

• "For years, SpaceX faced little serious competition, but that's starting to change." [He cites Blue Origin's progress toward approval for launching U.S. military satellites, and how Rocket Lab and Stoke Space "have also joined the competition for lucrative government launch contracts." Even Relativity Space may make a comeback, with former GOogle CEO Eric Schmidt acquiring a controlling stake.]

• "An infrastructure reset is coming. The imminent ramp-up of SpaceX's Starship could collapse the cost structure for the infrastructure layer. When that happens, legacy providers with fixed-cost-heavy business models will be at risk. Conversely, capital-light innovators in station design, logistics, and in-orbit servicing could suddenly be massively undervalued."

HP has agreed to a $4 million settlement over allegations of deceptive pricing practices on its website, including falsely inflating original prices for computers and accessories to create the illusion of steep discounts. Ars Technica reports: Earlier this month, Judge P. Casey Pitts for the US District Court of the San Jose Division of the Northern District of California granted preliminary approval [PDF] of a settlement agreement regarding a class-action complaint first filed against HP on October 13, 2021. The complaint accused HP's website of showing "misleading" original pricing for various computers, mice, and keyboards that was higher than how the products were recently and typically priced.

Per the settlement agreement [PDF], HP will contribute $4 million to a "non-reversionary common fund, which shall be used to pay the (i) Settlement Class members' claims; (ii) court-approved Notice and Settlement Administration Costs; (iii) court-approved Settlement Class Representatives' Service Award; and (iv) court-approved Settlement Class Counsel Attorneys' Fees and Costs Award. All residual funds will be distributed pro rata to Settlement Class members who submitted valid claims and cashed checks."

The two plaintiffs who filed the initial complaint may also file a motion to receive a settlement class representative service award for up to $5,000 each, which would come out of the $4 million pool. People who purchased a discounted HP desktop, laptop, mouse, or keyboard that was on sale for "more than 75 percent of the time the products were offered for sale" from June 5, 2021, to October 28, 2024, are eligible for compensation. The full list of eligible products is available here [PDF] and includes HP Spectre, Chromebook Envy, and Pavilion laptops, HP Envy and Omen desktops, and some mechanical keyboards and wireless mice. Depending on the product, class members can receive $10 to $100 per eligible product purchased.