Oh don't know, but if I could, you know, work through a ticket to completion without interruption, that would be great!
* Boss promotes too many tickets at once to the same priority. Meaning you work 3,4,5 or more tasks at the same time with similar time tables.
* People with tickets given a lower priority IM you again and again, and you keep telling them they are a priority 2 or 3... And until all the p0 and p1's are gone, you'll never even get a chance to look at it. Take it up with the boss if you want a higher priority.
* Dev and QA email threads you don't need to be on (yet, maybe) spamming your inbox. But you need to check if they actually are asking you something now, so you stop to read it.
* Walk ups. - Same as IM.
Let people focus on a task and get it done. If they get blocked, let them tell you they are blocked, and they can move onto another task until the first one becomes unblocked. It really can be that simple, if people will let it.