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I suppose it could happen but really down any of those artists using MegaUpload to distribute their stuff were the ones sending DMCA take down requests and if they were I would expect they would note that they were okay with MegaUpload distributing the file on another part of the site.
I read the first time you posted this. The flaw in your argument was easier to catch. I see that you have revised your post to make it more subtle. To think there could be no scenerio where the actual content owners would not object to their content being posted elsewhere on MegaUpload is just too narrow minded. For example someone may have uploaded a file to megaupload and getting paid for users downloading it via the affiliate program. If someone else uploads it the owner is denied his/her money.
I was trying to set up a foss mirror in our college and we finally settled with lighttpd because it was smaller/easy to configure.