1. CapsLock. Grr.
2. The numeric keypad on 15" laptops. Why? Why?! Why?!! It causes the rest of the keys to get scrunched up and moved to unnatural positions, and positions the trackpad offset left upto 3 or 4 inches, which makes for a horrible experience for a right-handed typist. The trackpad should ALWAYS be centered.
3. But please bring back full-size Page Up/Down keys (with maybe a shift action to Begin/End). I'm looking at you, Macbook Pro! Don't run and hide..