sheer marvel and scale
Both Sanford's "Genetic Entropy" and Behe's "The Edge of Evolution" contain back-of-the-envelope order-of-magnitude musings on "scale" related to the random-mutation-fantasy. David Swift's "Evolution Under the Microscope" stands out for repeatedly marveling over the "folding" issue, including the snip-and-rejoin magic needed to copy a helix. I mean I have repeatedly had the experience of spending tens of minutes unraveling a 50-meter stretch of 11-millimeter Edelrid perlon climbing rope, which is specifically designed to be easy-to-handle. The idea of your genome getting tied up into knots, I mean really you DO want to ask how it possibly AVOIDS getting tied up in knots !