The only stuff it was ever used for was crapware.
Actually, several enterprise web applications use it. Parent mentioned SharePoint, there are more than a few applications on J2EE servers which utilize it as well. One of the areas of the product I work on just released a new application to replace an older application which was dependent on NPAPI.
Customers have 1 of 3 choices at this point:
1) Downgrade Chrome - IT Security won't allow that, too risky
2) Upgrade the server code / install new application - IT Management won't allow that, too risky
3) Use something other than Chrome until #2 can happen - most likely choice in the short term
However I am in agreement the NPAPI needed to die. Google gave more than enough warning this was coming - TWO YEARS - so companies were given the opportunity to fix their code. Those that haven't - shame on you.