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I like ESET, especially the business version with console. I get it for my large customers.
Kaspersky is good. I use it for email gateways and small offices. The firewall breaks some shit, though.
I'm always removing viruses from computers that are running avast!, McAfee, Symantec, and AVG, so I won't be using those anytime soon
Trend Micro seems to be great, but I only have a couple of users running it so I have never used it in a large environment.
Vipre is a bad joke (I tested it).
MalwareBytes is great at removing crap and I use it often, but I have yet to use the paid version.
TDSSKiller http://support.kaspersky.com/v... for rootkits.
I'm thinking purchasing MalewareBytes for a small office soon (8 users), but I may go with Trend Micro. I'm on the fence.
What I do is to identify what sites are serving me ads, surf those sites while capturing packets using your favorite tool (NetworkTrafficView from Nirsoft if using Windows is easy) and block those sites using your firewall (IPs) and/or hosts file (FQDNs). I haven't seen a DoubleClick ad in years. In Windows my hosts file looks like this:
The Slashdot filter made me cut quite a bit out, but you get the idea.
This work has already been done and gets updated for you here: http://someonewhocares.org/hos...
My Windows Firewall is more extensive. I block massive subnets in Russia, Ukraine, and China (ex. LACNIC Latin American and Caribbean 22.214.171.124/8). This is all for a laptop that leaves the house. For an in-home solution you should get a better router and block them at the gateway so your iPad is safe too. pfSense is very flexible, but DD-WRT can do some neat tricks.