So far, the most successful ways to treat chronic pain from a pharmacological point of view are to create drugs that that interact or interfere with various channels in the brain to decrease pain, including adrenergic, opioid and calcium receptors.
However, there is another way – a chemical stimulator called adenosine that binds to brain receptors to trigger a biological response.
Adenosine has shown potential for killing pain in humans, but so far, no one has managed to harness this pain pathway successfully without causing a myriad of side effects.
Led by Dr Daniela Salvemini of SLU, the researchers discovered that by activating the A3 adenosine receptor in the rodents' brains and spinal cords, the receptor was able to prevent or reverse pain from nerve damage (the cause of chronic pain)."
Link to Original Source