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Comment: Re:Why? Why the hell *should* I help? (Score 1) 73

by Josiah Zayner (#45580669) Attached to: Crowdsourcing the Discovery of New Antibiotics
On the one hand I agree with you. Things can hit a critical point fast if human beings are not careful.
On the other hand(this one is my right hand I think) comfortability is what allows us humans to spend time thinking and developing technology and cool things and beautiful things! Where does one draw a line like you said. What if I am in extreme pain but it is not life threatening and the lab test for the bacteria takes two days? I guess we could make people suffer or we could give them antibiotics in hopes that the diagnosis was correct. Are you going to be the one that rejects giving the whiny mother the antibiotic only to have her child die? Maybe the chances are highly unlikely but who is the one who is going to be responsible for that?

In my view humans are super awesome. We can come up with new technology and invent ways to try and overcome difficult problems. As I said. Maybe you are correct and we are just creating super bacteria that are going to wipe us out. I guess I am just _hoping_ that we as humans overcome in the end. Maybe naively.

Comment: Re:biased sampling will cause problems. (Score 1) 73

by Josiah Zayner (#45580127) Attached to: Crowdsourcing the Discovery of New Antibiotics
Thanks so much!
Yeah, the project has many cool aspects. To teach Science, to bring awareness to antibiotic resistance, to start a massive open Science project.

The development of drugs is no small task, we know that! We are attempting to contribute what we can and allow others to contribute what they can. Often people think of how things are _now_ but not how they will be in the future. Regardless of whether we, or people who collaborate with us, or companies, develop these drugs the database should be pretty awesome to have around. Who knows, maybe in 50 years the NIH donates a bunch of money to develop one of these drugs, probably not but no one can predict the future. And if it is not done there never is any chance of that happening. So you do the best you can with the present and hope someone picks it up eventually.

Comment: Re:Who owns the IP? (Score 1) 73

by Josiah Zayner (#45579821) Attached to: Crowdsourcing the Discovery of New Antibiotics
We have no plans to monetize any of the data.

The original plan was to make all the data Open with a capital O. We are "open" to suggestions. It's just, I grew up on open source software. I use almost all open source software and it changed my life. Taught me to code and hack hardware and software. I couldn't imagine doing something different with my Science or the Science of a project I am working on. It's true a pharma company could just come in and take the data. What do we do though? If someone runs 1000s of samples I want them to receive any credit they deserve. Any press release or Scientific publication people will be mentioned in. At the moment that's the best we can do. Any ideas?

We current use gram negative bacteria, as most pathogenic/antibiotic resistant bacteria tend to be of this variety(though the most common known MRSA is positive). We are also thinking of promoting the use of skin cultures so it is a mix of positive/negative but that can be confusing when viewing the results of an assay. The prokaryotic specific effects is a great idea! Let me see what I can come up with. I will definitely throw you a free kit if the Funding succeeds and we implement it!

Comment: Re:Obvious questions (Score 2) 73

by Josiah Zayner (#45579517) Attached to: Crowdsourcing the Discovery of New Antibiotics
1. No, we are not. Finding new antibiotics doesn't require using drug-resistant pathogens. A new class of antibiotics, if found, would theoretically target a protein or process in a drug-resistant variant that is not drug-resistant from lack of evolutionary selection.

2. That is a big problem and something hard to deal with. From my knowledge current US patent laws are first to file not first to discovery. So either you collect results and don't make them accessible to anyone or you collect results and make them open and hope that they are used to help people.

+ - Scientists want to crowdsource the discovery of new antibiotics->

Submitted by Josiah Zayner
Josiah Zayner (3044297) writes "Katie Drummond at The Verge reports that "the Infectious Diseases Society of America warned that the pipeline of new antibiotics was "on life support," with only seven drugs in advanced stages of development to treat multidrug-resistant gram-negative superbugs. That's in part because, unlike drugs prescribed to treat chronic conditions, antibiotics are only taken for a few days or weeks at a time — meaning they're less profitable for pharmaceutical companies." Dr. Josiah Zayner, a synthetic biology fellow at NASA, and Dr. Mark Opal, a neurobiologist and drug development specialist have start an Indiegogo campaign: The ILIAD Project. ILIAD stands for the International Laboratory for Identification of Antibacterial Drugs. Contributors to the project will receive Science kits with all the materials needed for testing environmental samples, such as plants, insects, and bacteria, for antibiotic properties. The information will then be documented in Open manner on Wiki-style website to create the first Massively Multi-Scientist Open Experiment."
Link to Original Source

+ - The Chromochord: Biotech's First Musical Instrument Plays Proteins Like A Piano ->

Submitted by Josiah Zayner
Josiah Zayner (3044297) writes "The Chromochord allows a musician to vibrate proteins quantum mechanically with light just like they would a piano string. The basis of the Chromochord is the engineered Light-Oxygen-Voltage protein domain from Avena sativa(Oat). Absorption of light causes the chromophore in the protein to undergo a quantum mechanical energy transition that reversibly changes the absorption spectra and whose measurement modulates the pitch of notes being played. Josiah Zayner, the inventor of the Chromochord, has been working with the composer Francisco Castillo Trigueros to create complex musical compositions based on this protein nanotechnology."
Link to Original Source

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