EMACS is indeed the only software that ever caused me physical injury.
After a multi-day editing binge on a CKIE keyboard I went to the campus medical center. Muscle strain on my left pinky from rotate/stretch/curl of my large hands to hit control
Now, I would never tamper with University property but a couple of days later days later, there was a little piece of plastic next to my keyboard , and the shift-lock no longer toggled allowing me to remap the control key to where God meant it tone. . .