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Medicine

Submission + - The Cause of Parkinson's (futurity.org)

futurity.org writes: "Researchers have found an essential key that could lead to new treatments and possibly a cure for Parkinson’s disease. They have identified the protein that kills dopamine-producing cells in the brain—and a way to disable it." From Futurity.org
Biotech

Prehistoric Gene Reawakened To Battle HIV 360

Linuss points out research published in PLoS Biology that demonstrates the reawakening of latent human cells' ability to manufacture an HIV defense. A group of scientists led by Nitya Venkataraman began with the knowledge that Old World monkeys have a built-in immunity to HIV: a protein that can prevent HIV from entering cell walls and starting an infection. They examined the human genome for any evidence of a latent gene that could manufacture such a protein, and found the capability in a stretch of what has been dismissively termed "junk DNA." "In this work, we reveal that, upon correction of the premature termination codon in theta-defensin pseudogenes, human myeloid cells produce cyclic, antiviral peptides (which we have termed 'retrocyclins'), indicating that the cells retain the intact machinery to make cyclic peptides. Furthermore, we exploited the ability of aminoglycoside antibiotics to read-through the premature termination codon within retrocyclin transcripts to produce functional peptides that are active against HIV-1. Given that the endogenous production of retrocyclins could also be restored in human cervicovaginal tissues, we propose that aminoglycoside-based topical microbicides might be useful in preventing sexual transmission of HIV-1."
Science

Golden Rice 294

thue writes: "According to this story (reg. required) in the NY times "golden rice", ie genetically modified rice which contains beta carotene, could save a million children each year who would otherwise have died from malnutrition. The main reason golden rice is not yet in use is that the methods used in the creation was covered by patents, and getting a deal with the patent holders has delayed them one year (1,000,000 dead as a result!?). But the article also describes great resistance to everything GMO, even something as harmless and beneficial as this. Caution is understandable when dealing with powerful traits such as various kinds of resistance, but beta carotene...?" What I liked about it was that the developers hadn't crippled the strain's ability to reproduce. Genetically-engineered wheat is generally crippled, forcing farmers to buy new seed from the company year after year.

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