I'm fairly certain something about stone houses and throwing glass fits perfectly here.
The situation TheTurtleMoves described is one of the biggest issues with PayPal I hear about fairly regularly. They don't like something, they get a complaint, they'll yank money out of a linked account without even a pause to investigate, question it, contact you, etc. Everyone I've talked to in that situation then faces an uphill battle in which they try to convince PayPal to look again and handle the situation responsibly and fairly. Apparently contacting Paypal and getting a useful response is a miracle in and of itself.
There are plenty of people who will definitely be glad to move on from PCs but I honestly don't know any who are willing to make that jump currently. Whether the technology isn't there or the form factor is the cause of them sticking to PC habits, I know many technophobic/casual technology users who do not see their phone or their tablets as a replacement for their computer. Based on everything I've seen so far, those who do really replace a real desktop or laptop with one of these newer devices are in the minority.
It's hard to fully say where things will lead. Smartphones and tablets will advance and only increase in popularity and people won't be as driven to upgrade their laptops or desktops as often either, most likely. Is the number of PC users really shrinking significantly or are people migrating to a much slower upgrade path? Most of the reports on statistics making an argument one way or another that I've seen leave out too many important details that result in unanswered questions.
As best as I can tell, this whole post-PC era we're supposedly in is nonsense. Tablets, phones and other cute consumption devices are neat, and I wouldn't mind a tablet myself when they eventually mature, but there's no replacement for my home workstation. I've built my last few desktops myself and my current desktop is hitting around the 3 year mark and I'm starting to look at my upgrade path. I just got a new GPU, the CPU, RAM, mobo and PSU are my next upgrades and will likely occur as one single big hardware swap. An SSD would be nice too!
Back to the topic at hand: I don't see many people I know using their tablets to completely replace their 'real' computers. For some people laptops have started to replace desktops because they have lower demands and realistically laptop hardware seems to be much more on par than it was five years ago. As that continues to improve more people will probably ditch the desktop for a laptop, but that's still a 'PC' and there are still upgrade options like RAM and drives. I still wouldn't ditch a desktop for a laptop but in either scenario Newegg can continue to be successful. They sell laptops, they sell replacement parts.
Even if the Post-PC era weren't just marketing hype and news headline making nonsense, they still have plenty they can offer. NewEgg sells tablets too, they also sell software, home entertainment gear (I just got a new receiver from them) and all sorts of other things. I believe they have the ability to adjust themselves to changes in demand as needed, but I don't really think the PC business is in any danger of crumbling beneath them any time soon. New uses will emerge for computers, new games will come out demanding the latest technology and the best price/performance and the best choice for expansion continues to be the "desktop."
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I don't really see this having a big impact on most people. Do they want to spend $2300 on a Mac Pro which is currently a better deal than a comparable Precision, or $1300 on a Dimension which is plenty of machine for their needs?
Apple is giving a good deal on those, there's no doubt. The only way I could come close in cost/performance building it myself appears to be if I went with the slowest chip Apple offers since they aren't too astronomical online. However Apple is buying in "bulk" and prices will gradually drop (new chips are always inflated) and Dell is likely to fight back.