I didn't vote for Trump in the last 3 presidential elections so I'm hardly a fan, but here's probably what's going on with the NASA decision.
Trump always has a plan. Many people that dislike him think he doesn't but this is quite wrong. The plan may have only been thought of yesterday and/or it may be terrible, but there is always a reason for what he does. In my opinion, NASA has been run really well at least since the first Trump administration if not longer. The last couple of heads of NASA were terrific and Isaacman may end up being excellent too. Trump does actually care about space and his own legacy. We were already supposed to be back to the moon under Biden, but as always happens, there are always some kind of delays that push stuff out and Biden just shrugged them off. I think Trump is going to force NASA to get its crap together and get people back to the moon. There are plans for a permanent moon base. It would be a huge accomplishment for Trump to actually get this stuff done, so my guess is Isaacman pointed out that NASA isn't a problem and hasn't been a problem and keeping its employees around is a better way to get us back to the moon than randomly laying off people who work there. We need to get back to the moon and if Trump and his buddy Musk can accomplish that goal soon instead of the usual "Gee, maybe in 10+ years we can think about doing it" stuff that we've been getting, then more power to them.