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Comment: Re:we scrub at 5:30. (Score 1) 141

by UltraOne (#47258021) Attached to: I typically start my workday ...
Actually, in the healthcare context, using scrub as a verb most specifically refers to scrubbing your hands in preparation for surgery or another sterile procedure. It can also be used as a synecdoche for the entire process of the provider getting ready for surgery, starting at changing from street clothes to scrubs and ending with donning the sterile gown and gloves (or for a subset of that process if you already put your scrubs on earlier in the day).

Comment: Re:How about some other ideas (Score 1) 146

by UltraOne (#43989635) Attached to: Project Envisions Modular Aircraft That Double as Train Cars

I think an issue with the gull wing design would be that it would significantly complicate and perhaps also weaken the design of the fuselage, especially given the need for it to be pressure tight. My idea for a similar concept would be to have a circular seam at the back of the fuselage. The plane would be backed into the gate, the seam opened, and the tail swung out of the way (I've seen cargo planes that have that kind of hatch). Then the entire inside of the fuselage (passengers and baggage) would be pulled out the back onto a receiver structure in the terminal.

You would need a system of rails to allow for this movement and to couple the interior to the fuselage shell. There would also be a safety issue during the movement (since the fuselage moves relative to the passengers next to it in the window seats). A lightweight, non-structural shell that is part of the inside could be used. Alternatively, if the inner surface of the fuselage was completely smooth, with nothing that passengers or gear could catch on, perhaps it would be safe to slowly move the interior out of the fuselage.

Regarding the boarding order, what you are forgetting is that because of the scramble for overhead bin space, airlines allow higher priority passengers (more expensive tickets, frequent fliers, etc) to board first, and those people tend to have the better seats near the front of the plane. I never understood why when the airlines started charging for baggage, they didn't charge for carry on and make checked baggage free (or at least significantly cheaper than carry on). The current system on most US airlines (charge for checked baggage, carry on is free) obviously encourages people to carry more bags on the plane and, IMHO, is a major source of boarding delays.

Comment: Clinical Perspective (Score 3, Informative) 83

by UltraOne (#39303999) Attached to: Drug-Free Organ Transplants From Unrelated Donors

I am a pediatric blood & marrow transplant physician. I have read the article abstract, but I don't subscribe to Science Translational Medicine, so I won't be able to read the article until my hospital library orders & acquires the article. These comments are based only on the abstract.

The Slashdot summary is misleading about what is novel in research. Unrelated donor bone marrow transplants (or hematopoietic stem cell transplants (HSCT), which are a superset) have been done routinely since the 1990's.

Allogeneic (meaning the stem cell source is another person, rather than the patient himself/herself) HSCT patients take immunosupressive medications to try to prevent (or to treat) graft versus host disease (GVHD). If the patient does not develop GVHD, they are usually weaned off the immunosuppressive medications by 6 months after transplant. Patients who do develop GVHD can require years (sometimes 5-10 years) of immunosuppression. In contrast, patients who receive common solid organ transplants (heart, liver, kidney) are usually on immunosuppressive medications for life, although the immunosuppression is typically stronger for the first few months after transplant. The article reports on patients who received simultaneous kidney and HSC transplants from the same donor. Some of these patients could be weaned off of immunosuppression. Although this type of simultaneous transplant is not common, it has been reported before, as well as the finding that patients could come off immunosuppression.

What is novel is the ability to perform unrelated donor transplants using donors who were not good HLA matches (the matching system that is used for HSCT) and not have the recipients develop GVHD. This was accomplished by manipulating the stem cell product after it had been collected from the donor, but before it was infused into the recipient. The majority of HSCT done today are done with unmanipulated stem cell products (I'm not counting processing that often needs to be done when the donor and recipient don't have the same red cell type - which is controlled by a different genetic system than HLA). However, some forms of stem cell product manipulation (T-cell negative selection and CD34+ cell positive selection) have been around for a few decades. They can be successfully used to decrease the risk of GVHD, but at the price of increasing the risk of graft rejection, relapse (for leukemias) and infection. In the end, almost all studies of those methods show that the overall survival or disease-free survival is unchanged.

This article describes a more sophisticated form of stem cell manipulation, in which the graft is enriched in hematopoietic stem cells and tolerogenic graft facilitating cells. There have been past reports of other sophisticated stem cell manipulations giving good results in a study, but these techniques require elaborate facilities to perform, and often when they have been replicated by groups other than the original group, the patient outcomes have not been as good as those in the original report.

So my bottom line is that this result is exciting, but needs at minimum validation in a multicenter study before it starts to look like a game changer.

To address some of the other comments:

1) The concern about graft-versus-leukemia effects is a valid one and it will need to be studied. However, that is not an issue when doing a transplant for a non-malignant disease, so it would be a definite win for those patients. For leukemias, the GVL effect is strongest in CML, then AML, and weakest in ALL (kids don't get CLL, so I don't know much about that disease). Ultimately it would take clinical trials to determine if the benefit from less GVHD outweighs increased relapse risk (if any) from decreased GVL.

2) The article uses reduced-intensity radiation / chemotherapy, which isn't exactly a picnic, but it is less toxic than standard-dose (10-14 Gy) total body irradiation and 120 mg/kg cyclophosphamide (or 4 day busulfan and 120-200 mg/kg cyclophosphamide).

Comment: Re:One question (Score 1) 332

by UltraOne (#38036014) Attached to: Judge Makes Divorcing Couple Swap Facebook Passwords

IANAL, but the short answer is basically judges can order whatever they want in theory, although in practice there are significant limitations (more on that below). Another big point to mention is that the United States uses a common law system, meaning that large parts of the law have never been defined by a statute (i.e. a law passed by a legislature). The major limitations:

1. The judicial selection process almost always picks people who are not going to go off the deep end and start issuing crazy orders, but generally stick close to what is authorized by statutory, regulatory, or case law.

2. Orders from lower courts can be appealed and overturned by appellate courts.

3. There are mechanisms in place to impeach judges.

Within the law, there are various factors that limit orders judge are supposed to issue, and I suspect a relevant one here is jurisdiction. Divorce is a matter for state courts, and if the divorce is occurring in a state where Facebook doesn't have enough of a presence to bring it under the judge's jurisdiction, ordering the parties to swap passwords may be a lot simpler (from a legal perspective) compared to whatever they would have to do to bring another action in Federal court or in a state court with jurisdiction over Facebook to compel Facebook to turn over the data. I'm not sure why the court didn't just ask Facebook to turn over the relevant data. Of course it's also possible they did and Facebook refused, or the court knows that Facebook has refused similar requests (as distinguished from orders) in the past.

Comment: Re:Inflation (Score 3, Informative) 696

by UltraOne (#36933832) Attached to: Seigniorage Hack Could Resolve Debt Limit Crisis

This is a very good point. The Federal Reserve currently holds about $1.6 trillion in U.S. Treasury securities. So it would be possible to sell those securities (which pulls the money that others use to buy them out of the economy) so that the the coin hack had no net effect on the money supply until the Federal government spent more than $1.6 trillion.

I would argue that we need the additional fiscal stimulus given the weakness in the economy, and that stimulus would not be inflationary. For the people worried about inflation, though, having the Federal Reserve sell Treasury securities would delay any theoretically possible inflationary impact of the coin hack for about a year.

Comment: Re:Inflation (Score 5, Informative) 696

by UltraOne (#36933532) Attached to: Seigniorage Hack Could Resolve Debt Limit Crisis

I am the OP. As several people have posted, this approach is exactly equivalent to printing money. The reason it needs to be platinum coins rather than paper bills is that there is a law that limits the total value of paper bills that can be printed, but there appears to be no limit on the value of platinum coins that can be minted.

Of course, if you were to print a large enough amount of money, it would lead to inflation (or asset price bubbles, which actually seem to occur first in the current economy). The mechanism by which excess money supply causes inflation is by increasing demand to the point where bottlenecks appear in the economy. For example, people want cars, have money to buy them, but there aren't enough factories right now to supply demand - so the price of the limited pool of available cars is bid up. If labor markets are tight, employers looking for people to work to fill the demand created by the extra money will need to bid up wages to attract workers.

The key point is that all those mechanisms only work if an economy, or significant parts of it, are operating near peak capacity. This is the complete opposite of the situation we are in right now. Industrial capacity utilization was at 76.7% in June, several percentage points below the 1972-2010 average (80.4%) an well below the 85.1% peak in the 1990's. Unemployment is also high compared to historical averages.

In the current environment, it is vastly more likely that increasing the money supply will improve economic conditions without triggering inflation. Even at its pre-financial crisis recent peak (when unemployment was much lower than it is now), annual inflation (CPI-U, Dec 2006 to Dec 2007) was only 4.1%. Also keep in mind that the entire amount created ($5 trillion in my example in the OP) will not hit the economy at once. Initially it will be in an account at the Federal Reserve, and only as the government spends the money would it reach the economy.

Comment: Re:Postpone only (Score 4, Interesting) 696

by UltraOne (#36933248) Attached to: Seigniorage Hack Could Resolve Debt Limit Crisis
I am the OP. The reason this approach counts as an 'escape hatch' is that it appears that the executive branch already has the authority to carry it out (in 31 USC 5112(k) ). To stop it, Congress would need to pass a law. To do that in the face of a presidential veto would require 2/3 supermajorities in both the House and Senate. As long as Obama can get 34 of the 51 Democrats in the Senate (or 53 Democrats plus independents who caucus with the Democrats) to back this approach, there is nothing that the House can do to stop it.
United States

+ - Seigniorage Hack to Prevent Debt Limit Crisis-> 4

Submitted by UltraOne
UltraOne (79272) writes "With the US Senate voting to table the Boehner debt limit bill, the US is only a few days away from running out of cash to pay for all its obligations. Slate reported on a fascinating legal hack, described by blogger 'bewulf' back in January 2011. Seigniorage is the extra value added when government mints a coin with a face value greater than the value of the precious metal contained in the coin. The statute governing the minting of coins contains a section (31 USC 3112(k) ) that authorizes the Secretary of the Treasury to mint and issue platinum coins in any denomination or quantity. To keep the government from running out of money, Timothy Geithner could order 5 One Trillion Dollar platinum coins struck and deposited at the Federal Reserve. The money could then be used to fund Federal Government operations (blog post contains legal details)."
Link to Original Source

Comment: Re:Best case scenario? (Score 3, Interesting) 152

by UltraOne (#35256048) Attached to: Judge Rules Against China In 'Green Dam' Suit

Almost all of the US Treasury debt owned by China (and in general) is in the form of book-entry securities. This means there is no physical document for the treasury bill, note or bond. It exists as an entry in the database of a broker or the US Treasury. The court could simply order ownership of an appropriate value of those securities to be transferred from the Chinese government to the successful plaintiff.

Comment: Re:IANAL but... (Score 5, Informative) 152

by UltraOne (#35255828) Attached to: Judge Rules Against China In 'Green Dam' Suit

The Foreign Sovereign Immunities Act is the US federal law that regulates suits in US courts (federal or state) against foreign governments. It lists exceptions to the general rule that foreign states are immune to suit because of sovereign immunity. The exception that this suit is probably based on is the one that says a foreign state can be sued when it is engaged in “commercial activity”.

Assuming the plaintiff wins the suit, damages would be collected by seizing assets of the foreign state under US jurisdiction. Since US Treasury bonds owned by China are essentially promises by the US Treasury to pay a certain amount of money when the bond comes due, transferring ownership of those bonds to the plaintiff would seem to be a way of collecting damages. Of course, that might have diplomatic consequences.

IANAL either.

Comment: Re:The one they always overlook (Score 1) 454

by UltraOne (#34018018) Attached to: The Time Travel Paradoxes of Back To the Future

Because gravity is different from all other forces, and in some sense, is not a force at all. Mass (or more precisely, all components of the stress-energy tensor) changes the geometry of space-time so that the distances between objects, free of any forces acting on them, are different than what they would be in a flat Minkowski space-time.

An analogy is the difference in behavior between objects moving along lines that are initially parallel on a flat 2D plane and the 2D surface of a 3D sphere. On a plane, the objects will never meet. On a sphere, objects that start on adjacent lines of longitude at the equator (assuming the sphere is marked with latitude and longitude lines like the Earth), and move (initially in parallel) North will eventually meet at the North Pole. There is no force that pushes the objects together: they move together because of the geometry of the surface that they travel in.

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