If you're selling a $500,000 software product; going after pirates is not a winning business strategy -- it's figuring out, why the heck you can't pitch your product to legal buyers, and make your desired revenue there. Either the pricing is all wrong, or your marketing or product targetting is all wrong.
Who said it was the vendor going after him?
And it says in TFA that the Agilent product in question was a "product intended to speed the design process for electronic equipment". And it was $45,000, not $500,000. Still, Agilent charges $45,000 for that product because it's found people that are willing to pay it.
If you can't afford the software, or you don't think what it gives you is worth $45,000, then don't buy it. It's not for you. Don't bitch about it. Don't pirate it. Find something else in your price range.
And there's a big difference between going after pirates who post your stuff on TPB and a guy who made $30,000 (low ballpark) off your work.