Yep, it's true there are times when prefix notation is painful. I got used to it years ago, though, so it doesn't really bother me any more. For maths, I agree, it confuses but it's easy to drop that, or use a threading operator for non mathematical code. And it largely absolves me from the hassle of having to think about syntax the rest of the time.
Compromises in lisp as in all things.