I don't see society losing all knowledge, but I could envision a society where being a scientist is either
A) A secretive, priest-hood type profession - In this case, most people would see science and technology as magic. How does the car run? Nobody knows but the Scientist and he's not telling.
B) A reviled profession with people practicing it in secret, if at all - Think of this as the extreme version of the religious extremists' "science is a war on religion" view with religion winning. Study of science is banned and public sentiment is manipulated to make people who study science into outcasts. Technological development freezes and then backslides as those with knowledge can't even repair what we have.
A couple generations of this could easily result in a populace who wouldn't know what to do with a fully charged laptop with a local copy of Wikipedia if you gave it to them - or worse, a populace who would smash the laptop and hang you for heresy.