Comment: Scyld (Score 1) 264
Admittedly, my experience is a few years out of date, but it used to be that the immediate answer to this question was Scyld, the direct descendant of the original "Beowulf" cluster created at Goddard Space Flight Center by Donald Becker. We used it for 3d rendering and video processing and it was really slick, and being based on RHEL it was easy to get people who knew how to work on it/software updates/support in forums, etc.
I've only seen one comment in support of Scyld here, has it fallen out of favor for some reason?