Oh gods please, no... I use Salesforce extensively every day... my company was a small company that got bought by a bigger one - the bigger parent company wanted to push us to Microsoft CRM but we convinced them to leave us alone - we had so many customizations and neat uses of their API that switching would have bene a pain.
Our parent company just announced they were being bought by a bigger company and the bigger company is a Salesforce user - the sales and support people audibly CHEERED at the prospect of getting away from MS CRM and back to SalesForce... and I can see why.
If MS buys it, first it gets re-branded as MS CloudCRM or whatever then they just pillage and destroy it over the long haul and we end up back on MS CRM after they slowly ruin it over a couple years..
I know that's speculation, but DAMNIT, Salesforce is worlds better than MS CRM and I can't think they're buying to do anything other than gobble up a competitor.