Virtually every item of produce in your local Whole Foods was created by human intervention, not nature. The corn we buy is vastly different than the natural plant man developed it from, teosinte. The same goes for beets, carrots, corn, beans & potatoes, to name just a few. The originals are either inedible, poisonous or so poorly suited to agriculture we'd all starve to death if farmers didn't grow the modified versions.
Over time, we turned grey wolves into french poodles. Given enough time Monsanto could likely have bred plants that are immune to Round-Up as well. But a business plan that requires a few hundred years of selective breeding and forced mutation to have a good chance of obtaining and stabilizing the desired genetic profile wouldn't be a sustainable business plan in modern society. Plus, with modern methods there's less risk the resulting plant will have unfavorable genes like the one that makes wild almonds astringent tasting and poisonous instead of non-toxic and delicious like our selectively bred versions.