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Comment Re:Human Subjects (Score 2) 91

When the human testing starts, should it be old people first? afftected-continent people first? family-receives-high-payment people first?

Real clinical trials do not work like this. If you want to do a real trial, you first have to establish a team and treatment center that can administer your therapy and collect the data you need. You then establish EXCLUSION criteria, i.e., people who will not be included in the trial (usually old people, who have an annoying tendency to die, and children, because sick kids scare the shit out of most doctors). *Everybody* else who comes to the center, who has the disease, gets offered enrollment in the trial. It's up to them if they want to participate.

Anything else will get you laughed at, at the very least.

Comment Re:hmmmmm (Score 4, Informative) 390

Okay, I'll feed the AC troll.

I'm not talking about "most rashes"; real physicians have words to describe different kinds of rashes. The word that describes the rash of Ebola is "purpura." The distinguishing feature of this kind of rash is that when you push on it, it doesn't stop looking like a bruise. That is because the blood isn't contained within blood vessels that can be pressurized and allow the blood to be pushed out of the way. Because IT'S A FUCKING BRUISE.

Once blood leaves the vasculature, it is broken down into a couple of proteins. Hemosiderin is taken up by white blood cells. Biliverdin turns your turds brown (eventually). They make your bruises turn "black and blue" and eventually yellow. This takes days and is the reason why purpuric rashes don't fade immediately in response to anything.

You are conflating "hives" and "purpura." Kindly pay tuition if you want to continue.

Comment hmmmmm (Score 3, Interesting) 390

It seems possible that a monoclonal antibody might have a dramatic effect on virus replication. Since Ebola makes one ill by direct cell destruction it might even make one feel better quickly. But the rash comes from bleeding under the skin (it's the same as any big bruise you might have had). It makes no sense that it should fade immediately from the administration of a monoclonal against the virus. I hope this drug is successful in a trial, but at least that part of the article is suspicious.

Comment Re:Easy solution (Score 1) 453

I don't disagree with the general premise that reducing antibiotic use in livestock would be helpful in reducing the emergence of resistant strains of bacteria. I have to take issue, though, with the assertion that even eliminating entirely their use in the food industry would provide any sort of enduring solution. It would not.

The dirty little secret about antibiotic resistance that no one wants to talk about is this: resistance emerges from repeated use of different antibiotics in the same human, many of whom are not supposed to (according to nature) survive anyway. This group includes critically ill or injured people, cancer patients, patients with chronic organ failure, and most importantly old people. All of these groups have the common characteristic of impairment of immune function.

Antibiotics don't really "cure" infection. They kill enough of the circulating organisms so that the host immune system can take care of the rest. Some very good antibiotics don't kill any bacteria, they just stop replication. So if you actually wanted to create a petri dish for resistant organisms, you would take a host with poor immune system function, infect it, and give antibiotics that kill most of the bacteria and let the rest play on.

In this regard, the best possible "petri dish" is the transplant recipient. In something of a bittersweet triumph for modern medicine, the exact mechanism by which VRSA (vancomycin-resistant Staph aureus) would later emerge was predicted, carried out in the lab in an elegant esperiment which demonstrated the mechanism (plasmid exchange of the VanA resistance gene from VRE into Staph), and later confirmed when the first case emerged, in the Transplant ICU of the University of Pittsburgh Medical Center (ironically where transplants were originally perfected).

Biological systems have tons of complexity so there will be new drug targets in the future, but the obvious ones have been hit by now, so new drugs will be more expensive. The balanced approach would be to reduce antibiotic use on the human end, which inevitably brings up discussion of limits of care and "death panels." It is no accident that these pathogens tend to emerge in the U.S., where such discussion is difficult with our demographics, and where the entire population (doctors included) holds an almost mythical belief in the power of antibiotics. All they do (seriously) is rearrange the population of bacteria that inhabit your body. Sometimes that helps, a lot. We need to be honest about when those times really occur.

tl;dr Stop all the use of these drugs in livestock and you will only change the rate of emergence of resistance, not the fact. This problem is not going to go away.

Comment Re:Oblig. (Score 3, Interesting) 268

These are really big doses we are talking about, in the range of what external-beam radiotherapy uses to destroy tumors. When stating that four hours' dosage at this level is likely to be lethal, this means "likely to be lethal by acute radiation sickness with death occurring in days." In reality, much shorter exposures are likely to be lethal from induced cancers (leukemia and thyroid cancers being common). It will just take longer for those people to die. I suspect that most of the workers who have been on site to this point have likely had their fates sealed.

Comment Re:A cynic's view (Score 1) 637

I'd be "amazed how difficult it is to track accumulated values"? Are you fucking serious? Are you suggesting that the insurance companies that host this software don't know what patients are paying out-of-pocket down to the last decimal point? The rest of your post is just meaningless legacy code bullshit- there is simply no way that insurance companies haven't put customer out-of-pocket payments into their business models, which makes your whole point inane.

Comment Re:Bullets but not wheel weights?: (Score 2) 780

This right here is the most important point I have seen raised. It is the shooters that need to be concerned, especially when firing at an indoor range. Some small amount of lead is vaporized with every shot; you can easily smell the difference between jacketed and bare lead rounds. My city recently banned the use of unjacketed and semi-jacketed rounds at indoor ranges for this reason; nobody seems to be complaining.

Comment Re:Missing option: no outages here. (Score 1) 398

I envy you for that, and agree with you that power around here should be considered unreliable (else I wouldn't have a whole-house generator!). For this service I pay 14.3 cents/kwh. If I lived 50 miles further inland I could have buried power lines too, but the job is here by the coast. At least I don't really have to worry about tornadoes.

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